Anadolu University
  • Eskişehir, Turkey
Recent publications
A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives bearing an imidazole moiety has been prepared and their various biological activities are evaluated. The ability of forming intermolecular hydrogen-bonds of these molecules was pursued in the search of the best antimicrobial activity. The synthesized compounds were tested to search whether they had an enzyme inhibitory potency against AChE and BChE, which are the main targets for Alzheimer's disease. The prepared compounds were also screened for antituberculosis activity against M. tuberculosis H37Rv strain and the antibacterial activity against E. coli, A. baumannii, S. aureus, B. subtilis, A. hydrophila, bacteria. In addition, their antifungal activities are also evaluated against C. tropicalis, C. albicans, C. glabrata strains.
This research examines the impacts of social globalization, foreign direct investment flows, and financial development on environmental pollution in 107 countries. Unlike previous studies in the literature that have focused primarily on examining individual indicators of environmental degradation, a holistic index of environmental degradation is used in this current study. In addition, second-generation cointegration techniques and threshold regression estimators are used to examine the existence of long-term relationships and verify non-linear links between the variables of interest. The results confirm a long-term equilibrium relationship between the variables of interest in the context of the whole panel and in the sub-panels from different income groups. In addition, evidence on the threshold environmental effects of foreign direct investment inflows, financial development, and social globalization is also revealed. Especially concerning foreign direct investment inflows, we found that for in the entire panel and the upper-middle-income and low-income sub-panels, foreign direct investment reduces and increases air pollution before and after the threshold level. In lower-middle-income countries, foreign direct investment inflows cause increased environmental pollution before and after the threshold. Regarding financial development, we observe that before and after the threshold levels, financial development increases and decreases environmental pollution, respectively. Finally, it is identified that social globalization increases environmental pollution in the selected countries’ complete panels and sub-panels. Finally, the results of the causality test provide evidence in favor of the causal relationships between the variables, but it is evident that the causal directions are heterogeneous in the complete panels and sub-panels. Thus, these findings impose key policy implications concerning the environment-related United Nations Sustainable Development Goals.
Latin America is a region that is dependent on natural resources; thus, posing severe challenges for achieving economic progress along with social inclusion. This research aims to examine how the formation of trade blocs moderates the link between natural resource rents-economic progress in Latin America using non-linear econometric methods. In addition, we evaluate the moderating effect of urban concentration, knowledge, and the index of economic freedom. We find that the impact of natural resources on economic progress is non-linear and heterogeneous across trading blocs in the region. This finding shows that trade blocs moderate the impact of natural resources on economic growth in the Latin America nations. Our results suggest a threshold effect of the knowledge and index of economic freedom in the Latin American panel. In the Andean Community of Nations (CAN), we find a threshold effect of the natural resources rents and economic freedom index. In the Common Market of the South (MERCOSUR), we find a threshold effect of knowledge, urban concentration, and economic freedom index. The findings from the quantile regressions reinforce the conclusions that the link between natural resource rents and economic progress is heterogeneous across the distribution. Therefore, those responsible for economic policymaking in the Latin American countries must take advantage of the benefits of the exploitation of natural resources to diversify the economy and achieve Sustainable Development Goals 8 and 10.
In an attempt to identify small molecules for targeted therapy of non-small cell lung carcinoma (NSCLC) and prostate cancer (PCa), new arylidene indanones (1–10) were synthesized via the Claisen-Schmidt condensation of 5,6-methylenedioxy-1-indanone with p-substituted benzaldehyde. Compounds 1–10 were assessed for their cytotoxic effects on human lung adenocarcinoma (A549) and human pancreatic ductal carcinoma (PANC-1) cells as well as human normal lung fibroblast (CCD-19Lu) and human normal pancreatic ductal epithelial (hTERT-HPNE) cells. Among them, compounds 2, 4 and 10 were more effective on A549 and PANC-1 cells than cisplatin. Compounds 1 and 9 also showed more potent cytotoxic activity towards PANC-1 cells than cisplatin. In vitro assays were performed to assess their effects on DNA synthesis, apoptosis, caspase-3, mitochondrial membrane potential, intracellular calcium levels, morphological changes in cancer cells. Furthermore, all compounds were investigated for their inhibitory effects on cathepsin L (CatL) and cathepsin D (CatD). Compounds 2 and 4 exerted potent anti-NSCLC action through caspase-independent apoptosis induced by an increase in intracellular calcium level and correspondingly the disruption of the ΔΨm. These compounds also caused apoptotic morphological alterations in A549 cells. Compound 4 also inhibited both cathepsins but its inhibitory potency on CatL was more significant. Based on in vitro mechanistic assays, compound 4 was identified as a promising anticancer agent for targeted therapy of NSCLC. On the other hand, the marked anti- PCa activity of compound 1 mediated by apoptotic cell death is also noteworthy, but further enzymatic assays are required to elucidate its main mechanism of action.
The Bombax ceiba L. tree is a member of the family Bombacaceae and the genus Bombax. Both Chinese and Indian traditional medicine have made extensive use of it in the treatment of sickness. Its chemical composition is still a mystery. B. ceiba roots methanol extract (BCRME) was analyzed by different chromatographic analytical techniques in order to identify its major chemical constituents. Twelve compounds and six compounds were identified from GC-MS and LC-MS analysis, respectively. This is the first report on the presence of lathodoratin, cedrene, 4H-1-benzopyran-4-one,8-[fdimethylaminog methyl]-7-methoxy-3-methyl-2-phenyl, asiatic acid, and (E)-2,4,4'-trihydroxylchalcone in B. ceiba roots. Methanol extract demonstrated noteworthy antibacterial activity against Staphylococcus aureus (MTCC96) (MIC: 100 mg/mL) compare to antibiotic ampicillin (MIC: 250 mg/mL) as well as the highest a-amylase inhibition (IC 50 ¼26.91 mg/mL) and a-glucosidase inhibition (IC 50 ¼21.21 mg/mL) effects, molecular docking study confirmed these findings, with some compounds having a very high docking score. ARTICLE HISTORY
In recent years, automated feedback (AF) has greatly increased its applicability as a mean to support development of English as a foreign language (EFL) learners’ writing competence in the context of face-to-face education. This study examines contribution of AF to the development of writing competence of EFL learners in open and distance learning context. Anadolu University, Open Education Faculty learners received regular feedback on their writing tasks by an AF tool, Write & Improve. The contribution of AF to academic writing success was observed by statistically comparing the grades of the learners for their writing tasks at the beginning and at the end of the process and also by correlation analysis between AF frequency and achievement scores. In the second stage of the study, detailed data about learners’ experiences were obtained by interviewing volunteer participants. The quantitative and qualitative findings of the study showed that AF significantly contributed to the development of writing competence of EFL learners at a distance. Interviews with learners revealed themes such as effective learning process, contribution to foreign language development, motivation increase, effective and fast feedback, user-friendly learning environment, support for individual learning, and contribution to distance learning as the strengths of AF. The interviews also included participants’ suggestions on how to use these tools more effectively. Based on the findings, pedagogical implications are discussed regarding the incorporation of AF in distance EFL learning.
The growing energy demand in developing countries gravely influences households and calls for an emergent alternative such as biogas production technology (BPT). This research investigates the households' perception-based influence factors of BPT adoption in an innovation diffusion framework. A structural equation modeling (SEM) analysis is employed on a valid sample of 372 respondents in three districts of Central Punjab province (Pakistan). These questionnaire-based data are collected using random and convenience sampling techniques. The main results are: first, relative advantage, trialability, and observability are revealed to significantly drive BPT adoption, while compatibility and complexity impede the adoption process. Second, the relative advantage turns up the highest-ranked, whereas observability manifests itself as the lowest-ranked factor. Third, the relative advantage and compatibility emerge as the leading driver and bottleneck of BPT adoption, respectively. In closing, policies involving quality enhancement and efficiency improvement of BPT, local market development, the incentivization of households, and the introduction of some schemes to mitigate the investment risk in BPT are recommended.
The genera Nigella and Garidella are two members of the Nigelleae tribe. Among all the taxa of the tribe, black cumin (Nigella sativa L.) is one of the most important plants concerning economic and medicinal uses. In this study, volatiles were analyzed in detail to elucidate the phytochemical profiles and to understand the taxonomic patterns of secondary metabolites for 19 taxa of Nigella and Garidella collected from Turkey and the neighboring countries. Volatiles were analyzed by gas chromatography (GC-FID) and gas chromatography-mass spectrometry (GC/MS) using different polarity columns. Seventeen Nigella and two Garidella taxa were investigated, with 130 volatile oil components characterized. Structural similarities of the compounds were clustered by a machine learning algorithm using the molecular fingerprinting method. Our results depict that the phyto-chemicals produced by Nigelleae can be classified independently of their chemical families and significantly contribute to genera delimitation by their structural distances.
This study aimed to systematically review the literature focusing on music integration approaches adopted in preschool to secondary education in Turkey. The relevant studies were identified through a systematic search on five databases (The National Thesis Center, TÜBİTAK ULAKBİM TR Index, ERIC, Scopus, and Web of Science). The paper analyzed the publications that were written in Turkish and English between 2010 and 2022 and that are available on the databases of empirical theses and peer-reviewed scientific journals, addressing music integration approaches adopted in preschool to secondary schools by using qualitative, quantitative, and mixed methods. By operationalizing these criteria, 35 studies were included in the review. The studies included were found to tend to use quantitative methods. Music has mainly been integrated into math, science, and language arts curricula. This study revealed that most of the analyzed studies used a subservient integration style, an arts integration style, and offered limited insight into the depth and scope of subject areas covered and the sequencing of skills. Furthermore, this study proposed to consider educational, cognitive, artistic, and affective outcomes together by maintaining the integrity of each of the disciplines in music integration studies in the general schooling context.
In recent years, eco-friendly approaches and reduction in the use of hazardous solvents have become important in applications of routine high-performance liquid chromatography (HPLC). Despite its various health side effects, aspartame (ASP) is a widely used artificial sweetener due to its high sweetness and low cost. In this study, a green, eco-friendly, cost effective, rapid, robust, and simple high-performance liquid chromatography-evaporative light scattering detection (HPLC-ELSD) method has been developed and validated for the determination of ASP in beverages. Separation was conducted isocratically on a C18 (4.6 × 150 mm, 3.5 µm) column; the mobile phase consisted of 80:20 water:ethanol at a flow rate of 1 mL min⁻¹. The drift tube of evaporative light scattering detection (ELSD) temperature was adjusted to 50 °C and the nitrogen pressure was adjusted to 350 kPa. The HPLC-ELSD method provided a limit of detection and a limit of quantification of 0.33–0.99 µg mL⁻¹, with recoveries of 99.4 ± 0.68% and 102.8 ± 0.17%, respectively. The precision of the method as the relative standard deviation was less than 1%. The method permitted the determination of ASP within 8 min using only 6.4 mL water and 1.6 mL ethanol. This study shows that the developed HPLC-ELSD method is suitable for determination of ASP in the food industry.
Background: In metropolitans, where public transportation is used extensively, bus drivers are one of the occupational groups with a high risk of contracting COVID-19. Objective: This study aimed to assess the difference between the clinical status of a group of bus drivers and field officers with COVID-19 on public transportation lines in Istanbul. Methods: The study was conducted with 477 male volunteer participants. COVID-19 was confirmed through a positive nasopharyngeal culture sample using the real-time PCR test. Demographic information, biochemical parameters, clinical status, and the use of nutritional supplements were compared between those who recovered from COVID-19 at home or in the hospital. Results: The body mass indexes (BMI) of 83.9% of individuals was above normal and 75.4% were treated for the disease at home. There were significant differences in terms of age, BMI, weight loss, smoking, use of nutritional supplements, blood glucose levels and vitamin B12 values. However, there was no significant difference between the types of nutritional supplements used or other biochemical parameters. Conclusion: It was determined that those who survived the disease at home were younger and had a lower BMI. It is important for both individuals and for general public health to create healthy working environments, especially for bus drivers, who have a high risk of COVID-19 contamination and transmission due to their long exposure time.
Origanum onites L. of Lamiaceae, is used as a culinary spice and herbal tea; also for its antioxidant, antimicrobial effects among other activities and effects. This research aims to examine the in vitro antimicrobial and antioxidant activities of the infusions and the essential oils (EOs) obtained using different conditions from the aerial parts of the processed and raw of O. onites herbal material. The EOs from O. onites were distilled at different times and characterized both by GC‐FID and GC/MS systems. The resulting main compounds were identified as carvacrol (65.5‐91%), linalool (0.3‐17.9%), γ‐terpinene (2.8‐4.6%), and thymol (0.5‐1.5%), respectively. In addition, Origanum infusions were prepared at four different time intervals, where the volatile compounds of the infusions were analysed using the HS‐SPME‐GC/MS system. Statistical Principal Component (PCA) and Hierarchical Cluster Analyses (HCA) tools were used to demonstrate the composition variations on different times for O. onites infusion and EO samples.
With the development of educational technologies, electronic books (e-books) have been improved and adapted to cater to new teaching models, as well as to overcome several challenges reported by printed book portability. The literature about the benefits of e-books in education is still fragmented as several studies have reported distinct disadvantages in addition to advantageous of using them. Currently, no prior study has systematically reviewed the research on the ways e-books have been employed in education and the associated benefits and challenges. To address this gap, this study conducts a systematic review of 123 empirical studies on e-books in education. The findings show that the development and adoption of e-books by countries vary, calling for more international collaborations to facilitate the adoption of e-books worldwide. Additionally, several challenges of e-books were identified, such as eye fatigue and lack of knowledge on using e-books in education by both students and teachers. Therefore, it is suggested that more design strategies and training about using e-books can be conducted to enhance both teaching and learning experiences. Finally, it is argued that future research may focus on designing intelligent and open e-books to expand their use in different contexts and provide more personalized learning.
Luxury consumption is an appealing topic among researchers from the disciplines of psychology and marketing. Although past research on luxury consumption has provided a number ofmeasurement tools to measure brand luxuriousness, attitudes toward the concept of luxury, perceptions of luxury, and prestige shopping preference, researchers lack a scale that measures the luxury consumption tendency using a consumer-centric approach. To this end, this paper introduces the luxury consumption tendency scale, which was produced following the conceptualization of the luxury consumption tendency. Across three studies (total N = 1428), we developed an 18-item luxury consumption tendency scale that consisted of five dimensions. In Study 1, we conducted exploratory survey research of 11 Turkish Ph.D. students, and then, exploratory factor analysis was performed with the survey data collected from 520 Turkish undergraduate students. In Study 2, confirmatory factor analysis was performed on the survey data collected from 808 Turkish adults. In Study 3, we tested the validity performance of the luxury consumption tendency scale through a between-subjects experimental design in which 100 U.S. adults were randomly assigned to one of two conditions: a lowconstrual level condition and a high-construal level condition. The following results were determined across the three studies: the content, concurrent, convergent, discriminant, and nomological validity performances were established through descriptive (Study 1), cross-sectional (Study 2), and experimental (Study 3) designs. Additionally, the luxury consumption tendency was found to be positively associated with conspicuous consumption and status consumption. Furthermore, we demonstrated that as the construal level increases, so does the luxury consumption tendency.KeywordsConstrual levelLuxury consumptionLuxury consumption tendencyLuxury consumption tendency scaleScale development
Some indole analogues show a good analgesic activity but on the other hand, it has some serious side effects like gastric ulcer. Therefore, there is still a need to develop derivatives of non-steroidal anti-inflammatory drugs (NSAIDs) with fewer side effects. For this purpose, some indole derivatives were prepared with objectives to develop new derivatives with maximum efficacy and minimum side effects. 1-(1H-indol-1-yl)-2-(sübstituephenoxy)-ethan-1-one derivatives (M1–M4) were analyzed further by thin-layer chromatorgarphy (TLC), melting point, IR, and 1H-NMR. The synthesized compounds then underwent oral toxicity studies that include hematological, biochemical, and histopathological findings. The compound was then evaluated for in vivo anti-inflammatory and analgesic activities on carrageenan-induced rat paw edema and acetic acid-induced writhing methods. As a result of the biological activities, promising results were obtained in the compound M2 (2-(2-aminophenoxy)-1-(1H-indol-1-yl)ethanone) and it was subjected to further studies. It was found that compound M2 was practically nontoxic, and no clinical abnormalities were found in hematology and biochemistry, correlated with histopathological observation. It also showed significant anti-inflammatory and analgesic activities at its oral high dose (400 mg/kg). The study suggested that compound M2 was found to have significant anti-inflammatory and analgesic activities. The possible mechanism of M2 might suggest being act as a central anti-nociceptive agent and peripheral inhibitor of painful inflammation. The possible mechanism of action of the compounds whose biological activity was evaluated was explained by molecular docking study against COX-1 and COX-2, and the most active compound M2 formed −9.3 and −8.3 binding energies against COX-1 and COX-2. In addition, molecular dynamics (MD) simulation of both M2’s complexes with COX-1 and COX-2 was performed to examine the stability and behavior of the molecular docking pose, and the MM-PBSA binding free energies were measured as −153.820 ± 11.782 and −172.604 ± 9.591, respectively. Based on computational ADME studies, compounds comply with the limiting guidelines.
The final and most crucial step in obtaining clean water is disinfection. More innovative methods of water disinfection have recently been sought. Water disinfection is a promising application for nanoparticles as disinfectants. As a contribution to the literature, biofilm and metal-containing nanoparticles as antiadhesion inhibitors were used in conjunction with ultrasound in this study. The microbroth dilution test was used to reveal the microbiological antibacterial activities of different concentrations of AgNO3 and CuCl2 containing nanoparticles against the Escherichia coli ATCC 25,922 strain, which is an indicator bacterium in water systems. Antibiofilm activities were then investigated using biofilm attachment and biofilm inhibition tests. The inhibitory effect of nanoparticle ultrasonic waves on biofilm contamination was determined using a novel approach. Human keratinocyte cells (HaCaT cell line) were used in cell culture studies after water disinfection, and their cytotoxic effects were demonstrated using the MTT assay. The findings suggest that the nanoparticles utilized might be a viable choice for water disinfection applications. Furthermore, employing ultrasound at low doses with nanoparticles resulted in greater results. One feasible option is to employ nanoparticles to cleanse water without producing cytotoxicity.
Objectives In this study, the synthesis of three pyrazoline derivatives and the evaluation of their inhibitory effects on dipeptidyl peptidase (DPP-4) were aimed. Materials and methods Pyrazoline-based compounds ( 1–3 ) were obtained via the reaction of 1-(2-furyl)-3-(1,3-benzodioxol-5-yl)-2-propen-1-one with 4-substituted phenylhydrazine hydrochloride. The DPP-4 inhibitory effects of compounds 1–3 were determined with a fluorometric assay using Gly-Pro-Aminomethylcoumarin as the fluorogenic substrate. The cytotoxicity of compounds 1–3 on L929 mouse fibroblast (healthy) cell line was evaluated using MTT assay. Results 1-(4-Methylsulfonylphenyl)-3-(2-furyl)-5-(1,3-benzodioxol-5-yl)-2-pyrazoline ( 2 ) exhibited the highest DPP-4 inhibitory activity (IC 50 =5.75 ± 0.35 µM). Moreover, compound 2 exerted no significant cytotoxicity against L929 cells (IC 50 =34.33 ± 7.09 µM). Conclusions Target compounds exhibited moderate DPP-4 inhibitory activity and compound 2 was identified as the most active compound.
Alzheimer’s disease (AD) is a progressive and fatal neurodegenerative disease that is characterized by memory and cognitive impairments that predominantly affects the elderly and is the most common cause of dementia. As is known, the AChE enzyme consists of two parts. In this work, 10 new hydrazones (3a–3j) were designed and synthesized. Naphthalene, indole, benzofuran and benzothiophene rings were used to interact with the PAS region. 4-fluorophenyl and 4-fluorobenzyl structures were preferred for interaction with the CAS region. In biological activity studies, the AChE and BChE inhibitory potentials of all compounds were evaluated using the in vitro Ellman method. The biological evaluation showed that compounds 3i and 3j displayed significant activity against AChE. The compounds 3i and 3j displayed IC50 values of 0.034 and 0.027 µM against AChE, respectively. The reference drug donepezil (IC50 = 0.021 µM) also displayed a significant inhibition against AChE. In addition, the antioxidant activities of the compounds were also evaluated. Derivatives 3i and 3j, which emerged active from both in vitro activity studies, were subjected to in vitro PAMPA tests to determine BBB permeability. Further docking simulation also revealed that these compounds (3i, 3j and donepezil) interacted with the enzyme active site in a similar manner to donepezil. A few parameters derived from MD simulation trajectories were computed and validated for the protein-ligand complex’s stability under the dynamic conditions. Communicated by Ramaswamy H. Sarma
Summary: Introduction. Vocal fold nodules are the most common diagnosis in children with dysphonia. It is also frequently seen in professional voice users who uses their voice as an occupational tool. It can be caused by excessive or hyperfunctional use of the voice leading to phonotrauma. Children who learn the Quran by heart and recite it use their voices excessively and it causes voice problems. Voice therapy can play an important role in regulating phonotraumatic behaviors and improving voice quality, thereby replacing surgical intervention in some cases or acting as a complementary therapy to improve eventual therapeutic outcomes. Objectives. Our aim was to find the efficacy of group voice therapy compared to individual voice therapy in a group of pediatric professional voice users who go to the same religious school. Methods. To determine group therapy efficacy, 24 students between the age of nine and 14, were evaluated and 16 of them had vocal fold nodules. Therapy sessions started with 16 students whose ages ranged from nine to 14 with a mean of 11,3 § 1,4 years old. They were divided into two groups: group and individual therapy groups. Treatment comprised both direct and indirect voice therapy and lasted 6 weeks. Three of the participants were dropped out due to absence. Pre- and post-therapy measures were collected from 13 participants using perceptual evaluation, videostroboscopy measures, and the pediatric voice handicap index to determine the efficacy of group voice therapy compared to individual voice therapy with a group of pediatric professional voice users with vocal fold nodules. Results. As a result of our study, eight of participants were found to have healthy vocal folds; the s/z ratio was significantly different between groups and within group therapy participants pre- and post-therapy. No significant difference was found in other parameters; except noise harmonic ratio (NHR). NHR was found significantly dif- ferent between pre- and post-therapy when individual therapy and group therapy were compared. Although both treatments were shown to be beneficial in the management of vocal fold nodules, individual therapy was found to be somewhat more effective. Conclusion. In pediatric voice therapy, group therapy is an effective option to reach out to more individuals with voice disorders. It can be beneficial for time management and cost effectiveness in voice therapy.
About View Article Abstract Aim: Design of 5-methoxy benzofuran hybrids with 2-carbohydrazide and 2-(1,3,4-oxadiazol-2-yl) as potential inhibitors of monoamine oxidase (MAO)-B targeting Parkinson disease. Materials and methods: 12 compounds were synthesized and analyzed via high-resolution mass spectrometry, 1H nuclear magnetic resonance and 13C nuclear magnetic resonance techniques. In vitro fluorometric assay was used to investigate the activity of the synthesized compounds on both MAO-A and MAO-B isozymes. Results: Three compounds – 3a, 3c and 3e – displayed half maximal inhibitory concentration values of 0.051 ± 0.002, 0.038 ± 0.001 and 0.077 ± 0.003 μM in the inhibition of MAO-A and 0.048 ± 0.002, 0.040 ± 0.001 and 0.072 ± 0.002 μM for MAO-B, respectively. A molecular dynamics simulation study showed that compound 3c has poor stability as a complex with MAO-A. Conclusion: Compound 3c may be a potential candidate for the treatment of Parkinson disease.
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6,451 members
ugur - Demiray
  • Faculty of Communication Sciences
Fatih Demirci
  • Faculty of Pharmacy
Mustafa Sinan Kaynak
  • Faculty of Pharmacy
Selami Sezgin
  • Department of Economics
Zerrin Canturk
  • Department of Pharmaceutical Microbiology
Iki Eylul Campus, 26470, Eskişehir, Turkey
Head of institution
Prof. Dr. Tuncay döğeroğlu