Most of the solar cells that dominate the market are single-junction solar cells. These solar cells use mainly silicon, and some of them use relatively new materials like copper, indium, gallium, selenide (CIGS) and perovskite. These materials show a good performance, but they have a limitation of performance and are also costly or unstable. The strategy for improving the performance of single-junction solar cells in this paper is based on the use of promising material. The proposed single-junction solar cell uses germanium telluride (GeTe) as an absorber layer and zinc oxide (ZnO) as an electron transport layer. Germanium telluride has main advantages compared to many materials. It has a high electrical conductivity and a small energy gap, allowing it to absorb a larger portion of the input spectrum. The cell shows a 21.58% power conversion efficiency at room temperature using input spectrum air mass (AM 1.5). The effects of the doping profiles and thickness of the used materials are studied and improved to find the highest possible performance, and this improves short-circuit current density, open-circuit voltage and fill factor resulting in increasing the efficiency to be 33.18%.
Poor wound healing is considered an obstacle in diabetics, which requires effective therapy. Our goal was to investigate the combined effect of mint and silver nanoparticle hydrogel films as wound-healing agents in diabetic rats. Thirty rats were arranged into five groups. The hydrogel films were prepared through an eco-friendly method, excluding toxic solvents and diluents. Gel 1 and fucidin showed complete wound-healing effect on the 22nd day, while Gel 2 showed a faster effect on the 16th day, all compared to group 1 which healed in 25 days. Diabetic rats in group 2 healed beyond 25 days. Moreover, Gel 1 and Gel 2 decreased the fasting blood glucose. Gel 2 enhances wound healing in diabetic rats via multiple mechanisms of action, possibly due to the ability of mint and silver nanoparticles to sustain their concentration at the wound site with limited toxicity.
The development of effective and eco-friendly insecticides is a demand. Green nanoparticles synthesis is an important field in pest control strategy, which has cost effective and faster than physical and chemical methods. In this study, silver nanoparticles (AgNPs) were synthesized using Artemisia herba-alba plant extract to be tested against an important pest of non-edible plants such as cotton. UV-vis spectrophotometry, TEM, XRD and FTIR were used to confirm the biophysical characterization of AgNP formation, which appeared as spherical particles with size ranging from 9.68 to 36.7 nm. Feeding and contact application methods were used to evaluate the larvicidal activity of green-synthesized AgNPs against the cotton pest Spodoptera littoralis larvae. LC50 and LC90 values of synthesized AgNPs were calculated. After 5 days of treatment, the calculated LC50 of applied AgNPs by feeding application was 74.569 ml/ml (soln./ H2O), whereas contact application recorded LC50 of 27.47 ml/ml after 30 h of treatment. Morphological and histopathological abnormalities after AgNPs treatment were detected as demelanization and mummified shape of larvae, the destruction of the cuticle layer, disintegration of gut epithelia and gonad deformation. Our results proved the success of green-synthesized NPs application against S. littoralis larva, which open new avenues in pest control.
Background: Despite the great results of the SARS-CoV-2 vaccine, there is an increasing need for effective therapeutics. Increasing viral loads are associated with systemic inflammatory response, more disease progression, and increased mortality, while exaggerated immune responses result in immune overreaction and cytokine storm (CS)-induced acute lung injury. We hypothesize that ivermectin by reducing viral load and colchicine by reducing inflammation when used in combination might improve the outcomes of COVID-19 while offering cheap and safe options. Methods: A total of 135 COVID-19 patients were divided into three groups, with 45 patients in each group (colchicine/colchicine and ivermectin/neither of them). Group (A): ivermectin + colchicine + standard care, Group (B): colchicine + standard care, and Group (C): (control group) standard care. Results: We found that colchicine was associated with clinically significant decrease in days of oxygen need, length of ICU stay, less need for mechanical ventilation, and less mortality, while ivermectin failed to add any beneficial effect. Conclusion: Adding ivermectin to the treatment of moderate cases of COVID-19 is not of clinical value, while we support the use of colchicine in such cases. Trial registration: The trial was registered in February 2022 in ClinicalTrials.gov (NCT05246072).
Background Hepatocellular carcinoma (HCC) is considered one of the most common cancers related to mortality around the world, and susceptibility is related with genetic, lifestyle, and environmental factors. Copy number variation of the Bcell CLL/lymphoma 9 (BCL9) gene is a type of structural variation which can influence gene expression and can be related with specific phenotypes and diseases and has a role in hepatocarcinogenesis. Our aims were to assess the copy number variation (CNV) in the BCL9 gene and explore its role in HCV-related HCC Egyptian patients. A total of 50 HCV-related HCC patients were enrolled in the study (including 25 early HCC and 25 late HCC cases); the copy number of the BCL9 gene was detected using quantitative polymerase reaction. Results There was a highly statistically significant difference between the two groups (early and late HCC patients) in gender, bilharziasis, performance status, child score class, child grade, focal lesion size, portal vein, and ascites. CNV was detected and represented by the gain in the BCL9 gene in 14% of patients, and all of them were males. Also, it was noticed that the ratio of gain in BCL9 copy number in late individuals was about 1.5 times than that in early HCC individuals. Moreover, our results showed that the distribution of performance status > 1, average and enlarged liver, focal lesion size, thrombosed portal vein, and AFP was higher in patients with BCL9 copy number gain. Conclusion We detected about 14% gain in BCL9 copy number in Egyptian HCC patients. But the variation in copy number of the BCL9 gene did not affect HCC development in our patients’ cohort.
Background Male circumcision is one of the oldest and most commonly performed surgical procedures in the world; in fact, one of every 3 males in the world is circumcised. Plastibell circumcision is the commonest procedure performed worldwide with higher rates of satisfaction and lower rates of complications. Case presentation We present two cases, 4 and 5 months old with proximal migration of Plastibell ring with penile incarcerations that were managed successfully. We aim to highlight the necessary precautions needed to avoid serious complications after a minor surgical procedure. Conclusions Plastibell circumcision is a minor surgical procedure that is underestimated with the potential for major and serious complications. The implementation of the law against the practice of non-professional individuals, standardization of the procedure, and improvement of communication are highly recommended to avoid unnecessary and serious complications. Plastibell ring circumcision still needs further studies to examine ring antimigration, re-designing, and the best types and sizes of threads used. Lastly, studies are also needed to determine a cost-effective routine follow-up visit post-Plastibell circumcision procedures.
Background Metabolic diseases have been associated with childhood obesity no longer restricted to adults as previously known. Hypertension and diabetes mellitus (DM) have been reported in children with morbid obesity. Laparoscopic sleeve gastrectomy (LSG) has been used as a primary procedure for weight control among children and adolescents with acceptable records of effective weight loss together with evidence of improvement of associated co-morbidities. Results Thirty-two patients were diagnosed with morbid obesity and DM presented to obesity and nutrition clinic and were included in this study. Laparoscopic sleeve gastrectomy (LSG) was the chosen operation to treat their obesity and associated co-morbidities. Fasting blood sugar and HbA1c were measured before the operation and 1 year after surgery. Twenty-seven patients had significant improvement of their glycemic profile and managed to stop the hypoglycemic medication. Conclusion LSG may play an important role as a metabolic control procedure rather than a bariatric restrictive procedure only.
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