TABLE 7 - uploaded by Giuseppe R. Brera
Content may be subject to copyright.
Source publication
Person Centered Medicine (PCM) is a new inter-actionist, indeterministic, extrinsic Paradigm of Medicine, born in 1999, based on the Theory of the determinate and the quality indeterminate relativity of biological reactions” (1996). Structuring a new health epistemological model, developed from Medical Science base interactionist investigations, co...
Context in source publication
Context 1
... investigation, where results were presented for the first time in 2003 [49], demonstrated that PCCM leads to true medical practice quality improvement (Table 6). Data assessments by the Lombardia Region analyzing drugs prescriptions confirmed the described reduction of drug prescriptions in an extraordinary way, giving strong support to the argument that the more widespread adoption of Person-Centered Medicine could lead not only to the improvements in the patient's wellbeing, but also to important financial savings in health systems (Table 7). A major obstacle to the progress of the PCM revolution, according to the Ambrosiana University program, is to form clinical teachers and tutors who are able to apply PCM and PCCM in clinics and to teach it in pre-and post- degree courses. ...
Citations
... Interestingly, the inhibition of miR-21 following metformin was also observed in sera from 96 breast cancer patients enrolled in our randomized controlled trial to test the effect of different doses of metformin in modifying the hormonal/metabolic parameters linked to breast cancer prognosis. Various diets and dietary interventions including high-fat diets, calorie restriction, and the use of bioactive micronutrients and plant derivatives, have been associated with epigenetic changes that alter cellular signalling (4). Preclinical evidence suggests that components of Mediterranean diet (MedDiet), such as n-3 polyunsaturated fatty acids, 3,3'-Diindolylmethane from Brassica vegetables, resveratrol, folates, and other polyphenols decrease miR-21 expression. ...
Proceedings of the Conference : Medical science and health paradigm change
13-14-15 October 2017.Milan,Italy
... Interestingly, the inhibition of miR-21 following metformin was also observed in sera from 96 breast cancer patients enrolled in our randomized controlled trial to test the effect of different doses of metformin in modifying the hormonal/metabolic parameters linked to breast cancer prognosis. Various diets and dietary interventions including high-fat diets, calorie restriction, and the use of bioactive micronutrients and plant derivatives, have been associated with epigenetic changes that alter cellular signalling (4). Preclinical evidence suggests that components of Mediterranean diet (MedDiet), such as n-3 polyunsaturated fatty acids, 3,3'-Diindolylmethane from Brassica vegetables, resveratrol, folates, and other polyphenols decrease miR-21 expression. ...
Director of the Milan School of Medicine and Person Centered Medicine International Academy
SUMMARY Up to now, to our knowledge, medicine and medical science didn't ever submit to a scientific investigation clinical method. A reliable, valid, teachable clinical method is the basis of the Medicine progress and public health, because it is the condition of clinical picture assessment, the diagnostic process and the scientific hypothesis on one pathology nature, pathogenesis and therapeutic possibilities and the individuation of social diseases transmitted by environment and relations. Clinical Method is the basis of a "Person and people person care". Reliability means reproducibility of its application in N clinical contexts, its validity means its practical effectiveness for realizing its defined objectives for building diagnostic hypothesis, diagnosis, and a clinical improvement through the method structured application to the aim of taking care of and healing suffering persons. Up to now Medicine didn't discuss the traditionally used clinical method even if the medical science and human sciences progress opened new perspectives to clinics, identifying new clinical objectives and creating the necessity of change. The paper introduces in research and in Medical Education two new indexes: the Clinical Method Reliability Index (CMRI) and the Clinical Method Validity Index. Person Centered Medicine is the new paradigm of Medical Science, based on the interactionism among subjective, biological, environmental variables-well documented by basic science -interpreted and elaborated in a teleological way by the person. The Person Centered Medicine new paradigm, starting from the basic sciences progresses , and the epistemological revolution led by Allostasis, Epigenetics, Affect science and the Relativity theory of biological reactions, is based on the interactionism among subjective, biological and environmental variables interpreted by the person toward a conscious or inconscious personal realization in truth, love and
The continued production of variants of SARS-COV 2 due to the change of the Spike Proteins Receptor Binding Motif caused by the characteristics of the virus and the mass vaccination in epidemic time that promotes the immune evasion of the virus, leads to a delay in the production of vaccines after infections and clinical syndromes, which cannot prevent the spread of new infections. In addition, mRNA vaccines are genotoxic and cause a large incidence of even fatal adverse effects that have led in some states to the suspension of any vaccination in children-adolescents and young people under 39 years. The prevention of COVID-19 in Italy has been entrusted since December 2021 to a mass vaccination with experimental vaccine sera mrna and adenovirus vectors from monkeys and aborted fetuses whose DNA is hybridized with high probability in the DNA of the vaccinated, increasing the likelihood of autoimmune diseases and other even psycho-neurological problems. Before 2021 and after there was no secondary prevention in the population at risk, elderly people with comorbidities and people with atherosclerotic pathologies, despite research on SARS-COV of 2002-2003, and MERS 2009-2019, disappeared without vaccines with herd immunity. Primary prevention was limited to lock-down, distance teaching, the use of facial masks and hand washing (without indicating virocid temperature) and their disinfection along with touched objects, Simple technologies known for years to block virus transmission have been omitted. An obsolete epistemological perspective and serious omissions in the organization of prevention have led to the "lockdown", vaccine obligations without scientific validation of the possibility of infection, penalizing work and the economy. The use of masks and distance learning have penalised the mental health of children and adolescents and prevented the establishment of herd immunity by exposing children to increased vulnerability to other pathogens. Errors and omissions in primary prevention and the omission of secondary prevention in the population with comorbidities (93% of mortality), caused in Italy more than one hundred thousand deaths and millions of deaths worldwide. The wrong indications for early home care " Tachypyrin and vigilant waiting" by the Italian Health Minister and the rejection of effective hospital therapies such as hyperimmune convalescent serums have caused thousands of deaths.
Micro-RNAs (miR) are non-coding RNA filaments that control mRNA transcription. Micro-RNAs have been studied in cancer pathogenesis, metastasization, cancer therapy, the structuring of the central nervous system, diabetes, and heart disease. Mir-134-138 regulate the development of dendritic spines needed for synapses. Their silencing can lead to autistic spectrum disorders and mental retardation and damage to brains in evolution such as childhood and adolescence, producing learning problems and mood problems, and in adults for alterations of receptors for neurotransmission. It has been shown that N1-methyl pseudouridine binds to miR and induces silencing processes, increasing cell methylome at the origin of cancer. The production of mRNA vaccines replaces Uridine with N1-methyl-pseudouridine to escape innate immunity and implement rapid translation. N1-methyl-pseudouridine binding with mi-RNA alters the epigenetic transcription of oncosuppressor that, with the increase in cell methylation, could result in the induction of tumors and relapses, natural immunity inhibition, and neuro-behavioral disorders transmissible to progeny. Vectorial vaccines hybridize the host DNA with adenoviruses and induce tumors at the experimental level. Clinical reports and long-term epidemiological investigations are necessary to verify the impact of mRNA vaccines on health.
Acute stress causes a substantial upregulation on the epigenetic marks that shoot transposon activity, which has long term effects on the brain & behavior over the allostatic load and substantial changes of the somatic reactivity that is related with stress response and chronic disease. The increase of somatic transposon related with long life experiences has an indubitable consequence over health and disease.
Medical science and health paradigm change
Acordando con los modelos evolucionistas de la "Sensibilidad al contexto" y el diferencial de susceptibilidad, afirmo que existe un diferencial biológico que está mas vinculado a la plasticidad que a la noción de vulnerabilidad y que ese diferencial biológico, definido por el historial genómico-fenotípico se conforma a partir de la variación individual, la que combina plasticidad biológica y ontogenica, en la que los potenciales individuales en contextos de contexto adverso conducen al agravamiento o moderación de su vulnerabilidad (resiliencia).
In the last forty years there has been a great change of medical science through the progress of neurobiology, the birth of quantum biology, the development of epigenetics, the change of physiology with the concept of “Allostasis instead of “Homeostasis”, the opening of new interactionist investigation fields like Psycho-neuro-endocrine-immunology and the consequent formulation of the Theory of the relativity of biological reactions. At the same time there has been the integration of Medicine with human sciences such as cognitive psychology, psychoanalysis, counseling allowing to discovery a teleology of human nature. The change can be considered an indeterminist revolution of medical science, similar to the shift to quantum physics, from the Newtonian determinism and mechanism happened in Physics at the beginning of the last century. The epistemological change of Medicine is based on an irrefutable interactionism of three orders of variables belonging to subjectivity, biology and environment and to a natural tendency to give an objective meaning to life, giving importance to quality of life and lifestyle for the health construction. The concept of health appears related before its expression in the human biology, in a symbolic work made by the person addressed to interpret the quality of possibilities perceived in the external and internal experience in analogy to the interpretation work of biological information made by the membrane cell for answering to the adaptation requests. Disease, suffering, physicians are a personal experience of life that call for a meaning and a question for an answer that can’t be explained by empirical variables but that interact with these. The health definition introduced to WHO in 2011 in such a way appears:” The choice of the best possibilities for the best being a human person”. There is a true risk that Medicine could be developed on schizophrenic epistemology dissociated from the progress of the basic sciences. The Milan Conference held on 13-14-15 October 2017 wants to formalize a determinant shift for Clinics, clinical investigation, medical education and public health policy.
