Table 1 - available via license: Creative Commons Attribution 4.0 International
Content may be subject to copyright.
Source publication
This study was performed to evaluate their 5-year survival rates and identify the factors affecting the prognosis of oral cancer patients who had undergone surgical treatment only.
Among 130 patients who were diagnosed with malignant tumor of oral, maxillofacial, and surgical treated in the Department of Oral and Maxillofacial Surgery at Chonnam Na...
Context in source publication
Context 1
... cancer patients receiving surgery treatment were 58 male and 26 female, and the rate was higher 2.3 times in men, and overall, 5-year survival rate was 81.2 %. The disease-specific 5-year survival rate according to gender (women 84.6 %, men 82.5 %) showed no significant difference, and results of log rank test showed that sex does not affect prognosis (Table 1). According to the age distribution of oral cancer patients, affected age was 60 or more (55 patients, 65 %). ...
Similar publications
Introduction: Gorham’s disease, correspond to a massive osteolytic disease of the bones, characterized by destruction and resorption of one or more bones, spontaneous and progressive. The etiology of the disease is still unknown. The destroyed bone does not have the ability to regenerate or repair and is replaced by dense fibrous tissue. Bones of t...
![Figure 3. Measurement of D [prime] Using Digital Vernier Calliper.](profile/Ahmed-Al-Imam/publication/351491506/figure/fig3/AS:1022268478062596@1620739206948/Measurement-of-D-prime-Using-Digital-Vernier-Calliper_Q320.jpg)
![Figure 5. Mann-Whitney U Test for Sexual Dimorphism: D [ovale].](profile/Ahmed-Al-Imam/publication/351491506/figure/fig4/AS:1022268478066694@1620739206969/Mann-Whitney-U-Test-for-Sexual-Dimorphism-D-ovale_Q320.jpg)
Background: The base of the skull, particularly the pterygomaxillary region, has a sophisticated topography, the morphometry of which interests pathologists, maxillofacial and plastic surgeons.
Objectives: To conduct pterygomaxillary morphometrics and test relevant hypotheses on sexual and laterality-based dimorphism and causality relationships.
M...
Background
The 10-year survival rate of dental implants in healthy subjects is 90–95%. While in healthy individuals, dental implants have become commonplace to solve problems of edentulism, whether dental implant treatment is optimal in patients with systemic disease remains unclear. The purpose of this study is to investigate the clinical outcomes...
The development direction of bioresorbable fixing structures is currently very relevant because it corresponds to the priority areas in worldwide biotechnology development. Magnesium (Mg)-based alloys are gaining high levels of attention due to their promising potential use as the basis for fixating structures. These alloys can be an alternative to...
Citations
... Smoking, drinking, and sun exposure make males more likely to get OSCC than women. Males have a 2:1 to 4:1 prevalence rate over women [41][42][43]. Our Sudanese OSCC patients were usually elderly. ...
Background
In terms of survival rate, recurrent oral squamous cell carcinoma (OSCC) after primary surgery is considered as a poor prognostic indicator.
Objective
This study aims to determine the incidence of OSCC recurrence among patients treated at Khartoum Teaching Dental Hospital (KTDH) and possible risk factors associated with it.
Methods
Records of 303 patients with a history of radical surgery were retrieved from the hospital’s archives, and the histopathological records were retrieved from the archival specimens of Professor Ahmed Suleiman Oral Pathology Laboratory, Faculty of Dentistry, and University of Khartoum.
Results
Advanced stages of OSCC (III, IV) were associated with higher recurrence rates, and the poorly differentiated OSCC was the commonest recurrent type.
Conclusion
The condition of the surgical margin is a significant predictor of OSCC recurrence and tumor stage. The tumor site, the type of surgical resection, and the tumor differentiation were also identified as significant factors influencing the recurrence of OSCC.
... The gingival SCC group was the group with the lowest rate of cervical lymph node involvement, while FOMSCC was the group with the most N+ patients, as well as with advanced stages (III and IV). Survival in the GSCC group was longer than the other two groups, which is consistent with other similar studies (Kim et al., 2016;Ong et al., 2017). The lack of significant differences in these data could be related to the small number of cases in some groups. ...
Objective:
To analyze the clinicopathological and evolutionary profile of the main locations of oral squamous cell carcinoma (OSCC).
Materials and methods:
This is a retrospective study on 133 patients treated for OSCC. The group was composed of 48 women and 85 men, with a mean age 63.9 ± 12.73 years. Most cases involved the lingual border of tongue (63), followed by the gingiva (36) and the floor of mouth (34). A comparative analysis was performed using multinomial regression.
Results:
There were significant differences regarding age, sex, tobacco and alcohol consumption, liver pathology, oral potentially malignant disorders, and bone and perineural invasion. In multivariate regression, tobacco consumption, and bone invasion remained significant. There were no significant differences in relation to prognosis.
Conclusion:
The location of OSCC is an important factor in the clinicopathological assessment of this neoplasm. The main locations of OSCC show differential etiopathogenic and clinicopathological aspects. Tobacco consumption has a great relevance in the floor of mouth; nonetheless, it is less important in the tongue border and the gum, which suggests other pathogenic factors. It is necessary to consider the anatomical location of OSCC in preventive protocols, with the aim of reducing its high mortality.
... Moreover, we aim to analyze clinically significant prognostic factors which include age, sex, smoking, drinking habits, sites, perineural invasion, lymphovascular invasion, cell differentiation, depth of invasion, postoperative radiotherapy, recurrence, neck dissection, neck metastasis, pTNM stage. Due to the shortage of domestic epidemiological research on the OSCC survival rate and impacting factors, conducted over long-term follow-up, and involving a single surgeon and institution, this research holds particular significance [6,8,[21][22][23]. ...
Background
Oral squamous cell carcinoma has a poor prognosis. Therefore, prognostic factors are important to increase the survival rate. This study assessed the survival rate and the prognostic factors for survival of patients with oral squamous cell carcinoma.
Method
This study included 168 patients who underwent surgery for oral squamous cell carcinoma between January 2006 and December 2021. The survival rate was analyzed with overall survival and disease-specific survival. The patient’s age, sex, pTNM stage, primary sites (lip, tongue, mouth of floor, mandibular gingiva, maxillary gingiva, mandibular vestibule, maxillary vestibule, retromolar trigone, palate, buccal mucosa, primary intra-osseous site), smoking and alcohol drinking habits, depth of invasion, perineural and lymphovascular invasion, cell differentiation, and postoperative radiotherapy were evaluated to analyze risk factors. Kaplan–Meier methods were used to estimate the survival rates. Cox regression methods were used to investigate the main independent predictors of survival in univariable and multivariable analysis.
Results
Sixty-eight patients died of oral squamous cell carcinoma during follow-up periods. Their overall survival for 5 years was 51.2%, and the disease-specific survival was 59.2%. In univariable analysis, seven factors which are neck metastasis, depth of invasion, cell differentiation, lymphovascular invasion, postoperative radiotherapy, pTNM stage, and recurrence were significantly associated with survival. In multivariable analysis, pTNM stage and recurrence were significantly associated with survival.
Conclusion
In patients with oral squamous cell carcinoma, pTNM stage and recurrence were significant prognostic factors. Neck metastasis, depth of invasion, cell differentiation, lymphovascular invasion, and postoperative radiotherapy were also prognostic factors. These factors serve as markers for obtaining prognosis information in oral squamous cell carcinoma.
... O diagnóstico e o tratamento do câncer de boca em estágios iniciais estão associados à melhor qualidade de vida e sobrevida 5,6 . Assim, recomenda-se que pessoas que apresentam sinais ou sintomas da doença procurem imediatamente o serviço de saúde 7,8 . ...
Introdução: A identificação e a investigação de lesões suspeitas na cavidade oral são determinantes para o diagnóstico precoce do câncer de boca. A sobrevida dos casos diagnosticados e a qualidade de vida dos pacientes são diretamente afetadas pelo tratamento oncológico com pior prognostico em tumores avançados. Objetivo: Avaliar o impacto da pandemia da covid-19 na realização de procedimentos diagnósticos para câncer de boca no Brasil. Método: Estudo transversal com dados do Sistema de Informações Ambulatoriais do Sistema Único de Saúde (SIA/SUS). A média de procedimentos diagnósticos registrados mensal, semestral e anualmente no período pré-pandemia (2016 a 2019) foi comparada, por meio da variação percentual, com a produção registrada no período pandêmico (2020). Resultados: Observou-se diminuição dos procedimentos de diagnostico para o câncer de lábio e cavidade oral em 2020 comparado com o período de 2016 a 2019, com exceção das Regiões Sul e Centro-Oeste. A Região Nordeste apresentou a maior variação percentual negativa (-26,2%) entre a média de procedimentos realizados de 2016 a 2019 em comparação ao ano de 2020. Rondônia e Goiás apresentaram variação positiva, 66,2% e 43,5%, respectivamente. O país registrou as maiores reduções percentuais em abril (-43,2%) e em maio (-42,3%) de 2020, retornando a variação positiva apenas em dezembro (10,6%). Com exceção da Região Norte, o segundo semestre de 2020 foi pior do que o primeiro. Conclusão: A pandemia da covid-19 impactou a realização de diagnósticos de câncer de boca. Os achados indicam necessidade de orientações para profissionais de saúde e para a população sobre o caráter de urgência do diagnóstico de câncer de boca.
... When detected and treated at early stages the disease has a favorable prognosis, with 5-year survival rates reaching about 75-80%. 2 The disease mainly spreads to lymph nodes of the neck region through lymphatic drainage, but, although uncommon, there are other modes of tumor spread, like perineural invasion. We report a case of lower lip carcinoma with perineural spread and a unique clinical presentation. ...
We discuss a case of lower lip carcinoma which presented with atypical symptoms; facial paralysis, conductive type hearing loss, and ophthalmoplegia. Due to an earlier resection, no mass was evident on the primary examination. Diagnostic imaging revealed a mass originating from the lower lip, the perineural spread of the tumor along the left inferior alveolar nerve to the left infratemporal fossa and the left foramen ovale. Through a retrograde course from the foramen ovale, the tumor extended the ipsilateral cavernous sinus, Meckel's cave, and cisternal portion of the CN V. This atypical spread pattern of the tumor caused symptoms that may be attributed to a diagnosis related to the ear. The biopsy confirmed squamous cell carcinoma, and the patient was referred for chemotherapy and radiotherapy.
... Most typically, these latter patients are characterized as young non-smokers, most often females, presenting with HPV negative disease, with the most frequent subsite being the oral tongue [5][6][7][9][10][11][12][13][14]. Over the last 45 years, many studies reported that those young patients developing HNSCC, especially in the oral tongue, had a more aggressive disease and a worse prognosis than older patients, although some studies also reported no significant difference [15][16][17][18][19][20][21][22]. Family history of cancer in young relatives has been associated with head and neck cancer; therefore, suggesting the presence of a genetic factor in these patients [9]. ...
Genetic factors behind the increasing incidence of human papillomavirus (HPV) negative head and neck squamous cell carcinoma (HNSCC) in young non-smokers are suspected, but have not been identified. Recently, rs6942067, a single nucleotide polymorphism (SNP) located upstream of the DCBLD1 gene, was found associated with non-smoking lung adenocarcinoma. To validate if this SNP is also implicated in HNSCC, participants of The Cancer Genome Atlas HNSCC cohort were investigated for rs6942067 status, associated DCBLD1 expression, and clinical characteristics. Occurrence of the rs6942067 GG genotype is significantly higher in young and in HPV negative non-smoking HNSCC than in other HNSCC. Additionally, rs6942067 GG is associated with higher DCBLD1 expression in HNSCC and patients with high DCBLD1 expression have a worse overall survival at three years, both in univariate and multivariate analysis. Furthermore, high DCBLD1 expression is associated with activation of the integrin signaling pathway and its phosphorylation with EGFR and MET. Collectively, these findings suggest that DCBLD1 plays a critical role in HNSCC and demonstrate an association between rs6942067 and clinical characteristics of young age and HPV negative non-smoking status in HNSCC patients.
... Oral squamous cell carcinoma (OSCC) is a common malignancy worldwide, with regional variations in incidence and mortality [1][2][3] . The most common risk factors associated with OSCC are tobacco and alcohol abuse 4 ; however, the incidence in younger than 40 years without tobacco and alcohol abuse has increased 5 . ...
... Two factors that were related to OS and DSS were pTNM stage and presence of neck node metastasis. Studies have shown that patients with advanced-stage disease have lower survival 3 . In fact, a recent study states that the most important clinical predictor of survival remains TNM stage at the time of diagnosis 8 . ...
Objectives
This study evaluated the predictive factors for survival of patients with oral squamous cell carcinoma (OSCC) and investigated the overall and disease-specific survival (DSS) outcomes.
Materials and Methods
A total of 67 consecutive patients who underwent surgery for OSCC from January 2006 to November 2014 were included in this study. Patients were classified according to age, sex, pTNM stages, primary sites, smoking and alcohol drinking habits, depth of invasion, perineural and lymphovascular invasion, cell differentiation and postoperative radiotherapy. Kaplan-Meier methods were used to estimate the survival categorized by patient groups. Cox regression methods were used to investigate the main independent predictors of survival.
Results
Nineteen patients died of OSCC during follow-up periods. Another five patients died of other diseases including lung adenocarcinoma (n=1), cerebral infarction (n=1), general weakness (n=2), and pneumonia (n=1). The tongue (n=16) was the most common site for primary origin, followed by buccal mucosa (n=15), mandibular gingiva (n=15), maxillary gingiva (n=9), floor of mouth (n=9), retromolar trigone (n=2), and palate (n=1). Eleven patients had pTNM stage I disease, followed by stage II (n=22) and stage IV (n=34). No patients had pTNM stage III disease in this study. The overall survival of all patients was 64.2% and the DSS was 71.6%. DSS of patients with stage I and II disease was 100%. Stepwise Cox regression showed the two predictors for DSS were pTNM stage (P<0.0001, odds ratio=19.633) and presence of metastatic lymph nodes (P=0.0004, odds ratio=0.1039).
Conclusion
OSCC has been associated with poor prognosis; however, there were improved survival outcomes compared with past studies. Advanced-stage disease and presence of metastatic lymph nodes were associated with poorer survival compared with early-stage OSCC and absence of neck node metastasis. Stage I and II OSCC were associated with excellent survival results in this study.
... It is controversial to state that the tongue cancer outcomes in young patients (40 or under 40 years) are better than the outcomes in older patients (over 40 years). Many studies in fact support the conclusion that young patients have worse outcomes than older TSCC patients [4][5][6][7][8][9][10]. Many authors have reported that more aggressive approaches are needed for TSCC patients less than 40 years of age in cases of recurrence or distant metastasis. ...
Background
The incidence of tongue squamous cell carcinoma (TSCC) in young patients has recently increased, and these TSCCs are believed to be etiologically distinct from those in older patients, who have longer exposure to risk factors such as tobacco and alcohol. The prognosis of TSCCs in young patients remains controversial.
Methods
We retrospectively reviewed the records of 117 patients (2001–2011) who were diagnosed with squamous cell carcinoma of the oral tongue. Patients were divided into two age groups, older (ages over 40) and younger (ages 40 and younger). Data were compared between the two groups, and survival rates were analyzed.
Results
The results show that there are significant differences in overall, disease-free, and distant metastasis-free survival rates between the two groups. Five-year overall survival rates were 70% in older patients and 42% in young patients (p = 0.033). Five-year disease-free survival rates were 73% in older patients and 40% in young patients (p = 0.011), and 5-year distant metastasis-free survival rates were 97% in older patients and 62% in young patients (p = 0.033).
Multivariate analysis revealed that histologic grade was the only independent risk factor for overall survival in both groups of patients (p = 0.002, HR = 2.287). The analysis also demonstrated that age was the critical risk factor for distant metastasis (p = 0.046, HR = 9.687).
Conclusion
In this study, young (ages 40 and younger) patients with squamous cell carcinoma of the oral tongue had a higher rate of distant metastasis and a worse prognosis. Accordingly, we propose the necessity of an extensive therapeutic regimen that should be used in all young patients with TSCC.
... The most frequently diagnosed histological types of oral cancer are: Squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma, undifferentiated carcinoma, mucoepidermoid carcinoma, adenocarcinoma and malignant ameloblastoma (Borges et al., 2008). However, and concurring with the literature (Al-Jaber et al., 2016;Borges et al., 2008;Kim et al., 2016;Zheng et al., 2015), the greatest prevalence in this study was of squamous cell carcinoma. One of the most important risk factors for the development of oral cancer is smoking, where there are synergic effects between tobacco substances and concomitant use of alcohol (Petersen, 2009). ...
Introduction: Oral cancer is presented in different ways and variable complexities. These lesions present a high mortality rate, therefore, it is considered a severe health problem in the world. The treatment of these lesions is established according to extension, location, early detection and diagnosis. Objective: To characterize epidemiological aspects of diagnosed patients with oral cancer in a Brazilian population. Methods: Cross-sectional study, analytical-descriptive, retrospective, based on 3730 medical records of cancer cases provided by the Medical Service. The statistical descriptive analysis was performed together with the clinical, sociodemographic variables and risk factors. Results: In the period analysed, 77 cases of oral cancer occurred, accounting for 2.06% amongst all the cancer cases registered in the same period. There was a predominance of male individuals (73%), mixed race (57%), in the age range from 55 to 64 years old (29%), coming from urban areas (52%). Squamous cell carcinoma appeared in 78% of the cases and the most prevalent clinical findings were locations in non-specific areas of the tongue in stage III. Surgical approaches, in isolated modalities or associated with radiotherapy and chemotherapy were the most performed treatments. Conclusion: Oral cancer in the countryside of the state of Ceará is belatedly diagnosed and affects the majority of mixed race men in advanced ages. Tobacco and alcohol consumption presents high prevalence. The regions of salivary glands and tongue are the most common affected locations by this pathology. Copyright©2017, Amylla Keylla Silva Dias et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
... Lowgrade MEC is surgically excised in a single piece along with the involved underlying mucosa and bone for an adequate tumor-free margin 5 . High-grade MEC has local infiltration and regional lymph node metastasis 14,15 , requiring wider surgical resection with postoperative radiotherapy or chemotherapy 1,16 . Lymph node metastasis can occur in low-grade MEC 1 . ...
Mucoepidermoid carcinoma (MEC) is the most common type of malignant neoplasm in the minor salivary gland. The hard palate is a frequently involved site of MEC. The treatment of low-grade MEC on the hard palate is wide local resection with a tumor-free margin. In the present case, the maxillary defect was reconstructed using a buccal fat pad (BFP) flap, followed by application of 4-hexylresorcinol (4HR) ointment for 2 weeks. The grafted BFP successfully covered the tumor resection defect without tension and demonstrated complete re-epithelialization without any complications.
