Intravenous psilocybin dose-dependently disrupted theta-gamma coupling. Following psilocybin infusion, both the 1 mg/kg and 10 mg/kg doses resulted in decoupling of theta phase from medium (A) and high (B) gamma amplitudes in a dose-dependent fashion. PAC was not altered by the 0.1 mg/kg dose. Each grid represents a 10-minute average of PAC values across all rats (n=12). Each square indicates an electrode in the layout described in Figure 1. White and black asterisks: p<0.05, FDR-corrected post-hoc comparisons.

Contexts in source publication

Context 1

... compared to saline infusion, 0.1 mg/kg psilocybin did not produce any statistically significant changes in either theta-medium gamma or theta-high gamma PAC (p>0.05; Figure 4). In contrast, both 1 mg/kg and 10 mg/kg psilocybin infusion diminished theta-medium gamma PAC across the entire Figure 4A). ...

Context 2

... compared to saline infusion, 0.1 mg/kg psilocybin did not produce any statistically significant changes in either theta-medium gamma or theta-high gamma PAC (p>0.05; Figure 4). In contrast, both 1 mg/kg and 10 mg/kg psilocybin infusion diminished theta-medium gamma PAC across the entire Figure 4A). After 20 minutes of 1 mg/kg infusion, there was a decrease in theta-medium gamma PAC in the extreme frontal (p≤0.047) and posterior/occipital areas (p≤0.049), ...

Context 3

... PAC values started to recover back to saline values after the cessation of psilocybin infusion but remained significantly low at the end of 20 minutes post-psilocybin period (p≤0.038). The effect of 10 mg/kg psilocybin on theta-medium gamma PAC ( Figure 4A) was similar, but the onset time was faster (10 minutes after 10 mg/kg vs 20 minutes after 1 mg/kg psilocybin). ...

Context 4

... theta-high gamma PAC (Figure 4B) was only mildly affected by 1 mg/kg of psilocybin and with late onset (after 40 minutes of infusion). The decrease was restricted primarily to the frontal regions (p<0.050), which returned to saline values within 10 minutes after cessation of psilocybin infusion. ...

Context 5

... decrease was restricted primarily to the frontal regions (p<0.050), which returned to saline values within 10 minutes after cessation of psilocybin infusion. The 10 mg/kg dose of psilocybin showed a much stronger effect on theta-high gamma PAC, which showed wide-spread decreases across the cortex after 10 minutes of infusion (p≤0.048) and which remained significantly low through the post-infusion period ( Figure 4B). In summary, psilocybin infusion dose-dependently disrupted local thetagamma coupling across the cortex, but particularly in frontal cortex, potentially dysregulating information coordination. ...