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Inhibitory effect of Agavaceae family plants extracts against the mutagenicity of sodium azide to Salmonella typhimurium TA 100. aSansevieria cylindrica. bSansevieria trifasciata. cPolianthes tuberosa
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The application of natural antimutagens and antioxidants, particularly those derived from higher plants has been seen as a promising approach to the protection of human health. In this work, we studied methanolic extracts from Sansevieria cylindrica, Sansevieria trifasciata, and Polianthes tuberosa plants focusing on their antioxidative and antimut...
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Background
Sansevieria roxburghiana Schult. & Schult. F. (Family: Asparagaceae) rhizome has been claimed to possess antidiabetic activity in the ethno-medicinal literature in India. Therefore, present experiments were carried out to explore the protective role of edible (aqueous) extract of S. roxburghiana rhizome (SR) against experimentally induce...
Analysis of the MeOH extract of rhizomes of Sansevieria cylindrica using repeated silica gel and reversed-phase chromatographic separations led to the isolation of ten phenolic compounds (1-10) belonging to five different classes. Their structures, including the absolute configuration, were identified by NMR and CD spectra analysis. The antiradical...
Citations
... tissue is believed to be one of the crucial mechanisms suggested for plant extracts against blue molds (Pangallo et al. 2017). This is strongly related to the high antioxidant activity reported for the effective extracts, including S. cylindrica leaf extract (Karamova et al. 2016;Ahamad et al. 2017;Alexander et al. 2022), P. tuberosa tuber extract (Rumi et al. 2014), B. aegyptiaca fruit extract (Abdelaziz et al. 2020;Abdel-Farid and El-Sayed 2021) and A. nilotica fruit extract (Kumar et al. 2022a). The plant extracts might be involved in many other mechanisms suggested against blue molds, including the inhibition of nucleic acid biosynthesis (Wu et al. 2013), the alteration of pathogen cell structure, including cytoplasmic plasma membrane (Cushnie and Lamb 2005;Xu et al. 2011), induction of oxidative stress and downregulation of energy metabolism (Yang et al. 2016) and disruption of essential genes resulting in inactivation of enzymes (Telezhenetskaya and Yunusov 1977). ...
... S. trifasciata memiliki aktivitas antioksidan yang tinggi sebesar 47,3%-51,5% [10]. Bagian yang diteliti yaitu 4 bagian rimpang dan daun. ...
... Salah satunya yaitu metode serta pelarut yang digunakan dalam melakukan isolasi dari suatu sampel yang di uji. Beberapa peneliti menggunakan pelarut etanol untuk mengekstrak Sansevieria [13]- [19] dan adapula yang menggunakan metanol [10], [20]- [22]. Seperti yang telah dilakukan oleh Dewatisari, dkk,. ...
Mother-in-law's tongue leaves (Sansevieria trifasciata P.) is a plant of the genus Sansevieria with flavonoid compound namely trifasciatin, as an antioxidant. Antioxidants can be used in cosmetics to protect the skin from free radicals. The purpose of this research was to analyze antioxidant activity of mother-in-law's tongue leaves extract and to obtain the best lotion formulation with various concentrations. Samples were extracted using 96% ethanol solvent with maceration method. Antioxidant activity was tested using DPPH method and intensity was measured at λ=517 nm by UV-Vis spectrophotometer. The IC50 value=49.72 ppm indicates a very strong antioxidant activity, compared to vitamin C=4.01 ppm (very strong). Extract was formulated in lotion with various concentrations of 0.5%, 1%, 3%, 6% and the comparison was vitamin C with same concentration as well as base without the addition of active substances. Based on observations for 4 weeks, 3% extract lotion is the best formulation. The organoleptic test results showed no change in shape, texture, color, odor, and pH so lotion was stable. In addition, the value of viscosity, spreadability, adhesion, irritation test according to established standards also has an antioxidant value 99.72% (strong category). So effective to ward off free radicals on the skin.
... tissue is believed to be one of the crucial mechanisms suggested for plant extracts against blue molds (Pangallo et al. 2017). This is strongly related to the high antioxidant activity reported for the effective extracts, including S. cylindrica leaf extract (Karamova et al. 2016;Ahamad et al. 2017;Alexander et al. 2022), P. tuberosa tuber extract (Rumi et al. 2014), B. aegyptiaca fruit extract (Abdelaziz et al. 2020;Abdel-Farid and El-Sayed 2021) and A. nilotica fruit extract (Kumar et al. 2022a). The plant extracts might be involved in many other mechanisms suggested against blue molds, including the inhibition of nucleic acid biosynthesis (Wu et al. 2013), the alteration of pathogen cell structure, including cytoplasmic plasma membrane (Cushnie and Lamb 2005;Xu et al. 2011), induction of oxidative stress and downregulation of energy metabolism (Yang et al. 2016) and disruption of essential genes resulting in inactivation of enzymes (Telezhenetskaya and Yunusov 1977). ...
Blue mold caused by Penicillium italicum imposes a serious problem in economically important citrus fruit during the storage period. Traditionally, synthetic chemicals have been widely used to control blue molds; however, this use of chemicals has caused critical environmental problems. This has encouraged scientists to look for safer and readily available alternatives from natural eco-friendly sources such as botanical extracts. In line with that, the present study aims to investigate the antifungal efficiency of twelve methanolic extracts from eight plant species against P. italicum in vitro and to further select the most promising extracts to study their efficacy in vivo on reduction of disease severity and some physiological aspects of ‘Washington Navel©’ orange fruit under storage conditions. Being the most effective treatment, Sansevieria cylindrica leaf extract was subjected to GC-MS analysis to identify phytochemical components. The results obtained signified the potential efficacy of the tested plant extract to reduce the mycelial growth of P. italicum under in vitro conditions. The most effective extracts were Balanites aegyptiaca fruit, Polianthes tuberosa bulbs, Acacia nilotica fruit and Sansevieria cylindrica leaves at 1000 µg/mL inhibition % of mycelial of 54.3, 42.4, 41.3 and 31.5%, respectively. When compared under storage conditions of orange fruit, the lowest disease incidence and, thus, the highest reduction of disease severity (86.7%) were caused by S. cylindrica leaf extract. These effects were supported by high values of total phenols content (TPC) and total flavonoids content (TFC) in treated fruit, along with elevated activities of antioxidant enzymes: peroxidase (PO) and polyphenol oxidase (PPO). The identified phytochemicals in S. cylindrica leaf extract were dominated by fatty acids and their esters, which, together with the other compounds, have evidence of microbial activity. To sum up, using methanolic extracts of S. cylindrica as a substitute for chemical fungicides may help control P. italicum in ‘Washington Navel©’ oranges.
... The Yucca genus belongs to the Agavoideae subfamily, a subfamily that is commonly used in traditional medicine thanks to its anti-inflammatory, antimicrobial, and antiparasitic properties [1]. It encompasses about 40 to 50 species, most of which are native to southern North America. ...
The Yucca genus encompasses about 50 species native to North America. Species within the Yucca genus have been used in traditional medicine to treat pathologies related to inflammation. Despite its historical use and the popular notion of its antioxidant and anti-inflammatory properties, there is a limited amount of research on this genus. To better understand these properties, this work aimed to analyze phytochemical composition through documentary research. This will provide a better understanding of the molecules and the mechanisms of action that confer such antioxidant and anti-inflammatory properties. About 92 phytochemicals present within the genus have reported antioxidant or anti-inflammatory effects. It has been suggested that the antioxidant and anti-inflammatory properties are mainly generated through its free radical scavenging activity, the inhibition of arachidonic acid metabolism, the decrease in TNF-α (Tumor necrosis factor-α), IL-6 (Interleukin-6), iNOS (Inducible nitric oxide synthase), and IL-1β (Interleukin 1β) concentration, the increase of GPx (Glutathione peroxidase), CAT (Catalase), and SOD (Superoxide dismutase) concentration, and the inhibition of the MAPK (Mitogen-Activated Protein Kinase), and NF-κB (Nuclear factor kappa B), and the activation of the Nrf2 (Nuclear factor erythroid 2–related factor) signaling pathway. These studies provide evidence of its use in traditional medicine against pathologies related to inflammation. However, more models and studies are needed to properly understand the activity of most plants within the genus, its potency, and the feasibility of its use to help manage or treat chronic inflammation.
... Plants are the promising source of antimutagens which occur in them as secondary metabolites. Several plant extracts or their constituents have proved to contain a variety of antimutagenic and antigenotoxic compounds [5,6,7,8,9]. These antimutagens may help in strengthening cellular defences against environmental mutagens/ stress and thus preventing the development of several mutation-related diseases. ...
Stem bark aqueous extracts of eight woody plants Brachychiton populneus, Ceiba pentandra, Bombax malabaricum, Chorisia speciosa, Albizia lebbeck, Bauhinia variegata, Kigelia africana and Pinus halepensis were tested for their mutagenic and antimutagenic potential in the Ames test with Salmonella typhimurium strains TA98 and TA100. The aqueous extracts were neither toxic nor mutagenic in S. typhimurium tester strains. All of the tested extracts showed detectable antimutagenic effect towards the direct acting mutagens 2-nitrofluorene (2-NF) in TA98 as well as sodium azide in TA100. The extract from Kigelia africana was the most effective in reducing the mutagenicity caused by the direct mutagen 2-NF in the TA98 with 85.42% inhibition rate. A. lebbeck stem bark extract demonstrated the highest antimutagenic activity reducing the base substitution mutations rate for strain TA100 by 94.66% in pre-incubation assay. The results obtained showed that the stem bark aqueous extracts tested can protect cells against induced gene mutations.
... Plants are the promising source of antimutagens which occur in them as secondary metabolites. Several plant extracts or their constituents have proved to contain a variety of antimutagenic and antigenotoxic compounds [5,6,7,8,9]. These antimutagens may help in strengthening cellular defences against environmental mutagens/ stress and thus preventing the development of several mutation-related diseases. ...
Stem bark aqueous extracts of eight woody plants Brachychiton populneus, Ceiba pentandra, Bombax malabaricum, Chorisia speciosa, Albizia lebbeck, Bauhinia variegata, Kigelia africana and Pinus halepensis were tested for their mutagenic and antimutagenic potential in the Ames test with Salmonella typhimurium strains TA98 and TA100. The aqueous extracts were neither toxic nor mutagenic in S. typhimurium tester strains. All of the tested extracts showed detectable antimutagenic effect towards the direct acting mutagens 2-nitrofluorene (2-NF) in TA98 as well as sodium azide in TA100. The extract from Kigelia africana was the most effective in reducing the mutagenicity caused by the direct mutagen 2-NF in the TA98 with 85.42 % inhibition rate. A. lebbeck stem bark extract demonstrated the highest antimutagenic activity reducing the base substitution mutations rate for strain TA100 by 94.66% in preincu-bation assay. The results obtained showed that the stem bark aqueous extracts tested can protect cells against induced gene mutations.
The flowers of Yucca aloifolia (“flor de izote”) are considered a millenary food in the Northeastern Highlands of Puebla, Mexico. The present investigation reports on the chemical and biological activities of the hydroalcoholic extract (YAHF) obtained from this edible source. HPLC-MS profiling revealed twenty bioactive phenolic compounds with chlorogenic acid (16.5 mg g-1 DW), quercetin (9.5 mg g-1 FW), and their glycosides (rutin and quercitrin), as well as caffeic acid (8.4 mg g-1 DW) and ferulic acid (7.9 mg g-1 DW) as major compounds dissolved in YAHF. Six metabolites had potent anti-lipase (IC50 < 100 µg mL-1) and anti-ornithine decarboxylase activity (IC50 < 100 µg mL-1), whereas thirteen exerted strong anti-alpha-glucosidase properties (IC50< 100 µg mL-1). The evaluation of YAHF in mice subjected to standard oral glucose tolerance tests and prolonged administration of hypercaloric/atherogenic diet (30 days), unraveled their ability to improve glucose and lipid profiles. YAHF and six phenolic compounds significantly reduced DLD-1 cell viability (IC50, 117.9 µg mL-1) and avoided polyamine accumulation linked to anti-ornithine decarboxylase activity. YAHF and its twenty constituents exerted low toxicity in probiotics (> 1000 µg mL-1) and 3T3 fibroblasts (> 2.5 mg mL-1), sustaining their safeness for human consumption
A utilização de plantas para fins medicinais é uma cultura milenar que está ligada a humanidade desde seus primórdios e muitas destas plantas são empregadas atualmente nos rituais afro-brasileiros na cura e prevenção de doenças. O presente estudo buscou conhecer as plantas medicinais da cultura afro-brasileira utilizadas nos rituais de Umbanda, no município de São Borja no estado do Rio Grande do Sul, bem como seu uso místico e terapêutico. A metodologia adotada consistiu na análise textual discursiva que tem como finalidade produzir compreensões sobre os dados e informações qualitativas. Ao confrontar a literatura, 63,6% das plantas medicinais mencionadas nesta pesquisa possuem alguma indicação terapêutica mencionada pelos Umbandistas, auxiliando no restabelecimento da saúde humana. Além disso, foi possível corroborar com a carência de estudos interdisciplinares que investiguem as atividades biológicas das plantas, principalmente as relatadas como de uso comum nos terreiros de Umbanda. Resgatar este conhecimento é de suma importância para valorizar essa cultura na sociedade. Palavras-chave: Crença popular; cultura afro-brasileira; etnobotânica; diversidade religiosa. Abstract The use of medicinal plants as an element of cultural resistance and health care The use of plants for medicinal purposes is an ancient culture that has been linked to humanity since its beginnings, and many of these plants are currently used in Afro-Brazilian rituals to cure and prevent diseases. The present study sought to identify the medicinal plants of Afro-Brazilian culture used in the rituals of Umbanda, in the municipality of São Borja, state of Rio Grande do Sul, as well as their mystical and therapeutic use. The adopted methodology consisted of discursive textual analysis, which aims to produce understandings about qualitative data and information. The data obtained were compared with ethnobotanical studies published in recent years. When comparing the literature, 63,6% of the medicinal plants mentioned in this research have some therapeutic indication mentioned by Umbandistas, helping to restore human health. In addition, it was possible to corroborate the lack of interdisciplinary studies that investigate the biological activities of plants, especially those reported as being commonly used in Umbanda terreiros. Rescuing this knowledge is extremely important to minimize the negative image that this culture has in society. Keywords: Popular belief; afro-Brazilian culture; ethnobotany; religious diversity. Resumen Potencial para El uso medicinal y místico de las plantas utilizadas em los rituales de umbanda El uso de plantas con fines medicinales es una cultura milenaria que ha estado ligada a la humanidad desde sus inicios y muchas de estas plantas se utilizan actualmente en rituales afrobrasileños en la cura y prevención de enfermedades. El presente estudio buscó conocer las plantas medicinales de la cultura afrobrasileña utilizadas en los rituales de Umbanda, en el municipio de São Borja en el estado de Rio Grande do Sul, así como su uso místico y terapéutico. La metodología adoptada consistió en el análisis textual discursivo que tiene como objetivo producir entendimientos sobre los datos y la información cualitativa. Al confrontar la literatura, el 63,6% de las plantas medicinales mencionadas en esta investigación tienen alguna indicación terapéutica mencionada por los umbandistas, ayudando a restaurar la salud humana. Además, se pudo corroborar la falta de estudios interdisciplinarios que investiguen las actividades biológicas de las plantas, especialmente las reportadas como de uso común en los terreiros de Umbanda. Recuperar este conocimiento es de suma importancia para valorar esta cultura en la sociedad. Palavras clave: Creencia popular; cultura afrobrasileña; etnobotánica; diversidad religiosa.
Many members of the Asparagaceae family are used in traditional medicine in different countries and characterized by a high content of biologically active metabolites. In this work, the qualitative composition and quantitative content of the components of methanol extracts from leaves and underground organs of Sansevieria cylindrica Bojer ex Hook, Sansevieria trifasciata Prain, Polianthes tuberosa L., leaves of Yucca filamentosa L. and Furcraea gigantea var. watsoniana (Hort. Sander) Drumm. were determined. Extraction of plant leaves and underground organs using 80% methanol resulted in 5.2–16.7% and 16–25.1% of the total extractive substances consequently. The presence of steroidal saponins in the extracts was shown by thin layer chromatography. Spirostanol saponins were predominate in the extracts from leaves of Y. filamentosa, F. gigantea and underground organs of S. cylindrica, S. trifasciata, P. tuberosa, furastanol saponins – in the extracts from leaves of S. cylindrica and S. trifasciata. The content of terpenoid and phenolic compounds in the extracts established using spectrophotometry significantly differs depending on the plant species and their anatomical part. All the extracts tested exhibited inhibition of the 2,2-diphenyl-1-picrylhydrazyl free radical in dose-dependent manner. The highest antiradical activity demonstrated the extract from the leaves of Y. filamentosa (IC50 = 25.95 μg/ml) containing the largest amount of phenolic compounds, including flavonoids – 51.3 and 15.5% of the total extractive substances.
