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In vitro felodipine release profile from LPHNs formulations HF1,HF4 and the pure drug at HCl buffer pH 1.2 + 0.3 % polysorbate 80 solutions, the values of mean ±SD (n=3).
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The antihypertensive felodipine is a calcium-channel blocking agent. It is practically insoluble in water and shows low oral bioavailability (15%-20%). This investigation aims to formulate and characterize felodipine lipid polymer hybrid nanocarriers (LPHNs) to be given orally by two nanovesicles formulating methods and make comparative analysis th...
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... outcome ascertains there is no burst release of the therapeutic agent from all felodipine LPHNs formulations (HF1-HF6) and there was an extended-release process over 36 hours from all felodipine LPHNs formulations (HF1-HF6) (46) . In dissolution medium of HCl buffer pH 1.2 + 0.3 % polysorbate 80 solutions as shown in Figures (1,2,3), the felodipine release profile was significantly higher (p-value <0.05) in dissolution rate for HF3 and was significantly lower (p-value < 0.05) in dissolution rate of the pure drug. The comparability profile of felodipine release for formulas have similar concentration with different preparation method was explained as following: HF1> HF4, HF2> HF5 and HF3> HF6 while the comparability profile of the felodipine release from LPHNs formulation (HF1-HF6) and the pure drug suspension explains in the following descending order: HF3 > HF 6 > HF 2 > HF 5 > HF 1 > HF 4 > pure drug suspension. ...
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