Figure 5 - available via license: Creative Commons Attribution 3.0 Unported
Content may be subject to copyright.
Source publication
Mycobacteria, including nontuberculous mycobacteria (NTM) and Mycobacterium tuberculosis complex (MTB), are global pathogens of major concern due to their intrinsic drug resistance and their capacity to cause a wide range of severe infections. The treatment of mycobacterial infections is particularly challenging because of the multidrug resistance....
Context in source publication
Context 1
... inhibitors could also affect bacterial virulence, considering the relevance of these efflux transporters in processes such as biofilm formation [10] or construction of the mycomembrane in mycobacteria [107]. The initial step in the clinical development of drug resistance is a state of antibiotic tolerance promoted partially by efflux pumps that leads to the selection of bacteria with genomic mutations in antibiotic resistance target genes, resulting in clinical resistance (Figure 5) [9]. ...
