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Source publication
This study assesses the suitability of developing a material for use in an experimental model of the carotid baroreceptors. Such a model could then be used in future studies to assess the impact of carotid artery stenting on hemodynamic stability. The material must exhibit a significant measurable electrical response to strain in a fashion analogou...
Contexts in source publication
Context 1
... the strain range within which the ECS must replicate the carotid artery mechanical behaviour is between 11.3% to 21.5% (30% to 70% -10% to 90%), which will be taken as the approximate maximum value of 20%. The Yeoh SEF analytical curve and the average uniaxial tensile test data of five samples of the ECS are displayed in Figure 5, denoted as ECS -Yeoh and ECS -Expt respectively. Also included are published longitudinal uniaxial data for human carotid tissue obtained from Stemper et al. (2005) and circumferential and longitudinal uniaxial data of porcine carotid tissue obtained from Silver et al. (2003). ...
Context 2
... uniaxial tensile testing of the optimal ECS ratio was carried out to establish if this specific type of silicone exhibits suitable mechanical behaviour to act as a mimetic material of carotid arterial tissue. The testing shows that over a larger strain range the ECS behaves differently to human carotid arterial tissue as its stiffening response occurs at higher strains, Figure 5. However, the ECS material compares favourably to circumferential mechanical properties of porcine carotid tissue, which mechanically behaves similarly to human arterial tissue in the longitudinal direction, Figure 5(a). ...
Context 3
... testing shows that over a larger strain range the ECS behaves differently to human carotid arterial tissue as its stiffening response occurs at higher strains, Figure 5. However, the ECS material compares favourably to circumferential mechanical properties of porcine carotid tissue, which mechanically behaves similarly to human arterial tissue in the longitudinal direction, Figure 5(a). ...
Citations
... Conversely, the application of forces below the targeted toughness threshold in high toughness segments risk failing to propagate a controlled cut in the calcified plaque tissue. Subsequent expansion of the heavily calcified segment would result in the transmission of the applied high inflation pressures to the carotid baroreceptor leading to complications including hemodynamic depression [17,47]. An understanding of the luminal expansion mechanism achieved by CBA and the necessary forces required to propagate a controlled cut in the calcified plaque may help to translate this endovascular strategy into clinical benefit [13]. ...
Statement of significance:
Calcification plays a fundamental role in plaque tissue mechanics and demonstrates a diverse range of material moduli properties. This work addresses the characterisation of the toughness properties in human carotid plaque tissue using a fracture mechanics approach. Toughness determines the energy required to propagate a controlled cut in the plaque material. This parameter is crucial for predicting the cutting forces required during endovascular cutting balloon angioplasty intervention. Results demonstrate that a strong relationship exists between the structural calcification configurations, fracture mechanisms and associated toughness properties that are characteristic of specific regions within the carotid artery plaque. The identification of the morphological characteristics of localised calcification may serve as a valuable quantitative measure for cutting balloon angioplasty treatment.
