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Background: Benveniste's biology experiments suggested the existence of molecular-like effects without molecules ("memory of water"). In this article, it is proposed that these disputed experiments could have been the consequence of a previously unnoticed and non-conventional experimenter effect.Methods:A probabilistic modelling is built in order t...

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... Ever since 1988, when the French biologist Jacques Benveniste published the results of his team's research in the journal Nature and in some way founded the term "water memory" [3], there has been no single response of the scientific community towards this phenomenon. Indeed, even after 30 years, various questions, doubts and interpretations arise on this topic, and it cannot be ignored [4,5]. What still emerges today as relatively new, unknown, or rather insufficient is the ability of water to store and transmit information. ...
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Water is one of the five elements that man has been in connection with in a continuous, special and profound way throughout history. By its structure, an angle between atoms, polarity, binding, no doubt it is a fascinating element. Water comes in three aggregate states; it is a universal solvent and, interestingly, a rare substance on Earth whose density is decreased if water temperature is below 4 °C. This is why ice floats on water surface and what makes life possible. Recent very interesting studies have been made that point out the ability of water to store and transfer information. Aquaphotomics studies a so-far unknown world of water in a scientific way. There seems to be an influence on water and its structure through words, music, DNA, etc., via electromagnetic signals. The last four decades gave us an interesting insight through some interesting experiments. This should guide us not just to see the water in its chemical composition, but to see its spatial order of molecules too. Having this knowledge we should examine ourselves, fundamentally, based on the information we share and transmit. All human communication, negative or positive, and human action with and towards water can be reflected in the functioning of the human organism, other living beings, and the ecosystems that they are part of and interfere in.
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Quantum pharmacology introduces theoretical models to describe the possibility of ultra-high dilutions to produce biological effects, which may help to explain the placebo effect observed in hypertensive clinical trials. To determine this within physiology and to evaluate novel ARBs, we tested the ability of known angiotensin II receptor blockers (ARBs) (candesartan and telmisartan) used to treat hypertension and other cardiovascular diseases, as well as novel ARBs (benzimidazole-N-biphenyl tetrazole (ACC519T), benzimidazole-bis-N,N′-biphenyl tetrazole (ACC519T(2)) and 4-butyl-N,N0-bis[[20-2Htetrazol-5-yl)biphenyl-4-yl]methyl)imidazolium bromide (BV6(K+)2), and nirmatrelvir (the active ingredient in Paxlovid) to modulate vascular contraction in iliac rings from healthy male New Zealand White rabbits in responses to various vasopressors (angiotensin A, angiotensin II and phenylephrine). Additionally, the hemodynamic effect of ACC519T and telmisartan on mean arterial pressure in conscious rabbits was determined, while the ex vivo ability of BV6(K+)2 to activate angiotensin-converting enzyme-2 (ACE2) was also investigated. We show that commercially available and novel ARBs can modulate contraction responses at ultra-high dilutions to different vasopressors. ACC519T produced a dose-dependent reduction in rabbit mean arterial pressure while BV6(K+)2 significantly increased ACE2 metabolism. The ability of ARBs to inhibit contraction responses even at ultra-low concentrations provides evidence of the existence of quantum pharmacology. Furthermore, the ability of ACC519T and BV6(K+)2 to modulate blood pressure and ACE2 activity, respectively, indicates their therapeutic potential against hypertension.