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Local therapy strategies still provide only limited success in the treatment of glioblastoma, the most frequent primary brain tumor in adults, indicating global involvement of the brain in this fatal disease. To study the impact of neuroinflammation distant of the primary tumor site on the clinical course of patients with glioblastoma, we performed...

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... initiated glucocorticoid and antiepileptic medication at time of PET), patients with persisting epilepsy after initial successful treatment (i.e. temporary absence of solid tumor) of the primary tumor site showed significantly elevated TSPO-PET signals in the contralateral hemisphere (p = 0.040) compared to patients with discontinued seizures (Fig. 3A, additionally corrected for individual tumor therapy regimes). Interestingly, the only two patients presenting with persistent generalized tonic-clonic seizures indicated highest contralateral TSPO-PET signals among the group of patients with glioblastoma suffering from epilepsy (Fig. 3B). This finding suggests that epileptic seizures ...
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... (p = 0.040) compared to patients with discontinued seizures (Fig. 3A, additionally corrected for individual tumor therapy regimes). Interestingly, the only two patients presenting with persistent generalized tonic-clonic seizures indicated highest contralateral TSPO-PET signals among the group of patients with glioblastoma suffering from epilepsy (Fig. 3B). This finding suggests that epileptic seizures are also associated with alterations in brain regions distant from the primary tumor site. Sub-region analysis revealed elevated contralateral TSPO-PET signals (all p < 0.01) in all temporal . CC-BY 4.0 International license It is made available under a is the author/funder, who has ...
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... epileptic seizures (Fig. 3C). As an exploratory read-out, we investigated regional synchronicity of TSPO-PET within contralateral hemispheres. Here, patients with glioblastoma and persistent epileptic seizures indicated a strong increase of inter-regional TSPO-PET synchronicity compared to patients with discontinued seizures and healthy controls (Fig. 3D), speaking for globally elevated TSPO expression in brain as an indicator of epileptic seizures that will not suspend after tumor ...
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... overall survival (HR: 2.01, p = 0.022) when the whole battery of covariates was included in the multivariate Cox regression (Supplemental Table 3). Notably, regions with pronounced TSPO-PET signal elevation in the contralateral hemisphere of patients with glioblastoma compared to controls (Fig. 1E) showed stronger impact on overall survival ( Fig. 3G; i.e. mesial temporal median OS: 9.1 vs 19.1 months, Log-rank test: CC-BY 4.0 International license It is made available under a is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity. (which was not certified by peer ...

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