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Hemophagocytic lymphohistiocytosis (HLH) is a severe and life-threatening systemic inflammatory disorder. This retrospective study aims to evaluate the effectiveness of different therapies and identify early treatment responses maybe for indicators to overall survival. The study involved 102 patients from January 1, 2012, to December 31, 2022, usin...

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... the patients who received various treatments displayed different early treatment responses and OS, we investigated whether CR at 4 or 8 weeks was the primary mediator of the treatment effect on OS (Fig. 4). Our mediation analysis revealed that, compared to the HLH-94 protocol treatment, the HLH-04 protocol treatment did not have a signicant mediating effect on patient OS (P > 0.05). Blood purication has been shown to have indirect and direct effects on decreasing patient overall survival (OS), with a mediating effect of 33.28% at 4 weeks ...

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