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Cephalanthine (CEP), a bioactive compound derived from Stephania Cephalantha Hayata , is cytotoxic to various malignancies. However, the underlying mechanism of gastric cancer is unknown. CEP inhibited the cellular activity of gastric cancer AGS and HGC27 cell lines in this study. CEP induced apoptosis, reduced Bcl-2 expression, and increased cleav...
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... The Optical Density (OD value) of the solution obtained by dissolving cell colonies in glacial acetic acid indirectly demonstrated the ability of AGS and HGC27 cells to form colonies after CEP treatment. When the CEP treatment concentration was increased, the OD value of the obtained solution gradually decreased as compared to the control group ( Fig. ...
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... 48 h CEP treatment period, and the migration area almost completely covered the scratch area. However, as the CEP concentration increased, the area of cell migration after treatment gradually decreased. Finally, it was revealed in the cell scratch experiment that CEP signicantly and dose-dependently reduced the migration of AGS and HGC27 cells (Fig. ...
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... cytometry is then used to detect cell cycle changes. The results revealed that when AGS and HGC27 cells were treated with 15 µmol/L CEP, the number of cells in the S phase decreased, and the number of cells entering the G1 phase increased as compared to the control group (Fig. 2C). CEP also reduced cyclin D1 and CDK2 expression in AGS and HGC27 cells in a dose-dependent manner. Finally, these ndings reveal that CEP can inhibit AGS and HGC27 cell growth (Fig. ...
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... treated with 15 µmol/L CEP, the number of cells in the S phase decreased, and the number of cells entering the G1 phase increased as compared to the control group (Fig. 2C). CEP also reduced cyclin D1 and CDK2 expression in AGS and HGC27 cells in a dose-dependent manner. Finally, these ndings reveal that CEP can inhibit AGS and HGC27 cell growth (Fig. ...
