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The present study investigated the effects of perinatal exposure to glyphosate-based herbicide (GBH) on liver of immature Wistar rats. Female rats were exposed to GBH (70 mg glyphosate/Kg body weight/day) in drinking water from gestation day 5 and continually up to lactation day 15. The perinatal exposure to GBH increased ⁴⁵ Ca ²⁺ influx in offspri...
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Context 1
... status is involved in mechanism of hepatotoxicity of glyphosate. Thus, some biomarkers of oxidative damage were measured to evaluate the effects of perinatal GBH exposure on the liver of immature pups. Results showed that perinatal exposure to GBH increased the ROS-sensitive uorescence of H 2 DCFDA, suggesting a pesticideinduced ROS production ( Fig. 2A). Perinatal exposure to GBH also evokes lipid peroxidation (Fig. 2B) and increased protein carbonyl levels ( Fig. 2C) in the immature rat liver, indicating a pesticide-induced oxidative damage to lipids and proteins. The involvement of redox imbalance in the hepatotoxic effects of GBH was also supported by GSH depletion in the liver of ...
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... some biomarkers of oxidative damage were measured to evaluate the effects of perinatal GBH exposure on the liver of immature pups. Results showed that perinatal exposure to GBH increased the ROS-sensitive uorescence of H 2 DCFDA, suggesting a pesticideinduced ROS production ( Fig. 2A). Perinatal exposure to GBH also evokes lipid peroxidation (Fig. 2B) and increased protein carbonyl levels ( Fig. 2C) in the immature rat liver, indicating a pesticide-induced oxidative damage to lipids and proteins. The involvement of redox imbalance in the hepatotoxic effects of GBH was also supported by GSH depletion in the liver of the pesticide-exposed pups (Fig. ...
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... to evaluate the effects of perinatal GBH exposure on the liver of immature pups. Results showed that perinatal exposure to GBH increased the ROS-sensitive uorescence of H 2 DCFDA, suggesting a pesticideinduced ROS production ( Fig. 2A). Perinatal exposure to GBH also evokes lipid peroxidation (Fig. 2B) and increased protein carbonyl levels ( Fig. 2C) in the immature rat liver, indicating a pesticide-induced oxidative damage to lipids and proteins. The involvement of redox imbalance in the hepatotoxic effects of GBH was also supported by GSH depletion in the liver of the pesticide-exposed pups (Fig. ...
Context 4
... to GBH also evokes lipid peroxidation (Fig. 2B) and increased protein carbonyl levels ( Fig. 2C) in the immature rat liver, indicating a pesticide-induced oxidative damage to lipids and proteins. The involvement of redox imbalance in the hepatotoxic effects of GBH was also supported by GSH depletion in the liver of the pesticide-exposed pups (Fig. ...
