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Figure 6
Select Gene Expression Across Variable PrPSc Permissive Ovine Microglia
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  • Aug 2019
Background: Transmissible spongiform encephalopathies (TSEs) are a group of fatal, neurodegenerative diseases that affect multiple species, including sheep, cattle, and humans. A misfolded, pathogenic isoform (PrPD) of the normal, host-encoded, cellular prion protein (PrPC) is the causative agent for TSEs. While there have been advances in understa...
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... gene/PRNP expression ratios were pooled from Mock and Utah-inoculated clones for AXL/PRNP, BIRC5/PRNP and FN1/PRNP, and the impact of clone and inoculation status with expression, as well as correlations to prion permissibility were evaluated using similar procedures as described in section 3.4 ( Figure 6). Neither inoculation status, nor the interaction of clone with inoculation status were inuential to expression of genes selected for this portion of the study, so treatment groups were pooled to increase sample sizes. ...