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Background Around 40% of people with major depressive disorder (MDD) experience moderate remission, with the remainder meeting the criteria for resistant major depression (RMD). It has been shown that exercise has a low-to-moderate effect on MDD, but there is a lack of evidence on exercise interventions in RMD patients. The primary purpose of the p...

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... (depressive symptoms) will be measured with the Montgomery-Asberg Depression Rating Scale (MADRS) using the validated Spanish version (17). Secondary outcome variables will include CRF, body composition, biochemical and functional outcomes, and quality of life. The SPIRIT gure showing the time points for assessments and intervention is shown in Fig. ...

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