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Plasma amino acid levels are altered upon many pathological conditions including acute pancreatitis. It is unclear whether amino acids can be used as specific biomarker of acute pancreatitis severity or recovery. Development of acute pancreatitis is associated with mitochondrial dysfunction and decreased cytosolic ATP level. Sodium pyruvate is cons...
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Context 1
... conrm that pancreatitis did develop, we performed histological examination of the pancreas and electron microscopy after animal sacrice. In control animals, the acinar cells of the pancreas had normal morphology, and no changes in the parenchyma and duct system were detected (Fig. 1a). In pancreases of animals with L-arginine-induced acute pancreatitis strong immune cell inltration and diffuse reduction of acinar cells size with areas of necrosis were observed (Fig. 1b). Sodium pyruvate administration did not improve pancreatic morphology as assessed with a histological examination (Fig. ...
Context 2
... animal sacrice. In control animals, the acinar cells of the pancreas had normal morphology, and no changes in the parenchyma and duct system were detected (Fig. 1a). In pancreases of animals with L-arginine-induced acute pancreatitis strong immune cell inltration and diffuse reduction of acinar cells size with areas of necrosis were observed (Fig. 1b). Sodium pyruvate administration did not improve pancreatic morphology as assessed with a histological examination (Fig. ...
Context 3
... and duct system were detected (Fig. 1a). In pancreases of animals with L-arginine-induced acute pancreatitis strong immune cell inltration and diffuse reduction of acinar cells size with areas of necrosis were observed (Fig. 1b). Sodium pyruvate administration did not improve pancreatic morphology as assessed with a histological examination (Fig. ...
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Plasma amino acid levels are altered upon many pathological conditions including acute pancreatitis. It is unclear whether amino acids can be used as specific biomarker of acute pancreatitis severity or recovery. Development of acute pancreatitis is associated with mitochondrial dysfunction and decreased cytosolic ATP level. Sodium pyruvate is cons...
