Figure 1 - uploaded by Eoghan Cunnane
Content may be subject to copyright.
Source publication
This study assesses the suitability of developing a material for use in an experimental model of the carotid baroreceptors. Such a model could then be used in future studies to assess the impact of carotid artery stenting on hemodynamic stability. The material must exhibit a significant measurable electrical response to strain in a fashion analogou...
Contexts in source publication
Context 1
... A threshold and saturation pressure under and above which the baroreceptor firing rate is unresponsive to strain [ Figure 1(a)]. ...
Context 2
... Asymmetric responsive behaviour indicated by hysteresis present between firing rate during baroreceptor stretching and un-stretching [ Figure 1(a)]. ...
Context 3
... Adaption to a new firing rate base value when subjected to prolonged stretch as depicted by section B in Figure 1(b). ...
Context 4
... Recovery to base value following a step response to carotid sinus stimulus as depicted by section C in Figure 1(b). Note: Pressure forced back to 170 mmHg at time 12.5 s Source: Danielsen and Ottesen (2003) CAS has a deleterious effect on baroreceptor function due to the sustained stretch caused by balloon deployment. ...
Context 5
... averaged data for the three samples tested for these phenomena is displayed in Figure 8 with the baroreceptor response over a 25 s period developed by Danielsen and Ottesen (2003) inset. Figure 8 Electrical behaviour of the ECS regarding adaption to sustained strain and recovery from sustained strain which is qualitatively similar to the baroreceptor behaviour seen in Figure 1(b), inset ...
Citations
... Conversely, the application of forces below the targeted toughness threshold in high toughness segments risk failing to propagate a controlled cut in the calcified plaque tissue. Subsequent expansion of the heavily calcified segment would result in the transmission of the applied high inflation pressures to the carotid baroreceptor leading to complications including hemodynamic depression [17,47]. An understanding of the luminal expansion mechanism achieved by CBA and the necessary forces required to propagate a controlled cut in the calcified plaque may help to translate this endovascular strategy into clinical benefit [13]. ...
Statement of significance:
Calcification plays a fundamental role in plaque tissue mechanics and demonstrates a diverse range of material moduli properties. This work addresses the characterisation of the toughness properties in human carotid plaque tissue using a fracture mechanics approach. Toughness determines the energy required to propagate a controlled cut in the plaque material. This parameter is crucial for predicting the cutting forces required during endovascular cutting balloon angioplasty intervention. Results demonstrate that a strong relationship exists between the structural calcification configurations, fracture mechanisms and associated toughness properties that are characteristic of specific regions within the carotid artery plaque. The identification of the morphological characteristics of localised calcification may serve as a valuable quantitative measure for cutting balloon angioplasty treatment.
