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(a) UV–vis absorption spectra of DOX; (b) UV–vis absorption spectra of EPI; (c) UV–vis absorption spectra of MIT. Conditions: DOX, 18 μg mL −1 ; EPI, 12 μg mL −1 ; MIT, 9.0 μg mL −1 ; PTX, 18 μg mL −1 ; ctDNA, 2.0 μg mL −1 ; pH 7.4 

(a) UV–vis absorption spectra of DOX; (b) UV–vis absorption spectra of EPI; (c) UV–vis absorption spectra of MIT. Conditions: DOX, 18 μg mL −1 ; EPI, 12 μg mL −1 ; MIT, 9.0 μg mL −1 ; PTX, 18 μg mL −1 ; ctDNA, 2.0 μg mL −1 ; pH 7.4 

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... It was found that the binding of taxane to serum albumin can occur near the binding sites of DOX to serum albumin, and can induce surrounding conformation changes of serum albumin [28]. Chen et al. have found that taxane can significantly enhance the resonance light scattering (RLS) signal and improve the binding ability of anthracyclines to DNA using RLS technique [29]. Zeng et al. have demonstrated that DOX can interfere with the cytotoxic effect of DOC on both mitotic arrest and apoptotic cell death through DNA fragmentation analyses, flow cytometry and cell rotation analysis [30]. ...
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