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(a) Docking results of catechin against the enzyme acetylcholinesterase. (b) Close-up of the docking pose catechin (with residues labelled).

(a) Docking results of catechin against the enzyme acetylcholinesterase. (b) Close-up of the docking pose catechin (with residues labelled).

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There is increasing interest in Australian finger lime (Citrus australasica) due to its nutritional and bioactive potential. In this study, polar extracts from five finger lime cultivars were investigated for their potential bioactivity using a range of assays: antioxidant capacity (total phenolic content (TPC), ferric reducing antioxidant power (F...

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Context 1
... of the compounds, including catechin (−10.0 kcal/mol), quercetin-3-glucoside (−9.3 kcal/mol), cyanidin-3-glucoside (−9.1 kcal/mol), and apigenin (−9.0 kcal/mol), showed quite negative docking energy scores. Visualisation of the docking results for the most potent compound (catechin; Figure 2) showed that it bound to the active site of the enzyme, confirming the validity of the docking scores. This suggests that these compounds may bind strongly to acetylcholinesterase and could potentially inhibit its activity, supporting the observations of anti-AChE activity seen in Section 3.3. ...
Context 2
... and apigenin (−9.0 kcal/mol), showed quite negative docking energy scores. Visualisation of the docking results for the most potent compound (catechin; Figure 2) showed that it bound to the active site of the enzyme, confirming the validity of the docking scores. This suggests that these compounds may bind strongly to acetylcholinesterase and could potentially inhibit its activity, supporting the observations of anti-AChE activity seen in Section 3.3. ...