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Introduction
Systemic Lupus Erythematosus is a systemic immune disease that classically occurs in young to middle-aged women and may present with cutaneous, renal, hematologic, neurological, and/or other symptoms at the time of diagnosis. Late-onset Systemic Lupus Erythematosus or Systemic Lupus Erythematosus in the elderly is a subtype that differ...
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... before admission were amlodipine 10 mg, and aspirin 81 mg. The physical examination including the musculoskeletal examination, skin examination was unremarkable except for pallor seen on the conjunctiva, and ulcers on the lips (Fig. 1). Her blood pressure was 135/82 mmHg with a pulse of 76 beats per min. No enlargement in lymph nodes was observed. No hepatospelomegaly was ...
Citations
... However, some studies suggest using a higher age cutoff of 65 years and older to define l-SLE patients [5]. Since SLE is typically considered a disease affecting young or adult patients, the delay in diagnosing l-SLE is significant and has been reported to be up to 60 months [7]. Lateonset SLE differs from early-onset SLE (e-SLE) in several aspects, including gender and ethnicity prevalence, clinical manifestations, laboratory outcomes, progression of organ damage, disease activity and severity, prognosis, and mortality [5,[7][8][9]. ...
... Since SLE is typically considered a disease affecting young or adult patients, the delay in diagnosing l-SLE is significant and has been reported to be up to 60 months [7]. Lateonset SLE differs from early-onset SLE (e-SLE) in several aspects, including gender and ethnicity prevalence, clinical manifestations, laboratory outcomes, progression of organ damage, disease activity and severity, prognosis, and mortality [5,[7][8][9]. The predominance of females in SLE decreases with advancing age [5]. ...
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide range of clinical manifestations and a relapsing-remitting course. The peak incidence of SLE occurs during the reproductive years; however, it can develop at any age. Late-onset SLE, which is diagnosed at age 50 or older, accounts for approximately 20% of all SLE cases. The comparison between late-onset SLE patients and their early-onset counterparts has revealed distinct differences in clinical characteristics, comorbidities, and mortality rates. Late-onset SLE patients exhibit lower frequencies of mucocutaneous, renal, hematological, and neuropsychiatric symptoms but higher rates of serositis, peripheral polyneuropathy, cardiovascular diseases, and pulmonary involvement. Additionally, they experience a greater burden of comorbidities and increased mortality rates. Here, we review the clinical characteristics, comorbidities, and mortality of patients with late-onset SLE.
