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Ulcerated plaque on the cavum of the right sole
Source publication
Basal cell carcinoma is the most frequent skin cancer, generally located in hair-bearing, sunlight-exposed areas. Basal cell carcinoma usually occurs on the head and neck, but very rarely on extra-facial locations. We report a case of a 65-year-old woman presenting with a solitary non-healing ulcer on the sole of the right foot for two years. Histo...
Context in source publication
Citations
... Early diagnosis plays a crucial role in reducing morbidity, enabling less aggressive surgery and complex reconstruction [1]. BCC on the sole of the foot accounts for <1% of all reported cases in the literature (Table 1) [3][4][5][6][7][8][9][10][11][12][13]. ...
... However, the aetiology of BCC in extra-facial regions, such as the sole of the foot, is not fully understood as these areas receive less UV radiation exposure and consist of glabrous skin. Previous research suggests that the development of BCC in less sun-exposed areas may be associated with inherited disorders like basal nevus syndrome, exposure to radiotherapy or immunosuppression [6]. However, with our patient and most of the cases identified in the literature search, there were no significant associated risk factors [4-6, 8, 9, 12, 13]. ...
Basal cell carcinoma (BCC) is the most common form of skin cancer. BCCs are seldom reported on the sole of the foot due to a lack of exposure to UV radiation which is the main risk factor. We present a brief literature review and case report of a 42-year-old female with a non-resolving lesion on the mid-arch of her left foot over a 20-year period. Tissue diagnosis identified the lesion as a BCC. Disease-free control was achieved but the patient experienced significant morbidity resulting in three separate procedures to diagnose, excise and reconstruct the defect. When evaluating lesions on the sole clinicians should consider BCC as a differential, particularly in those which do not respond to initial treatment.
... In this location, it fits into the differentials of nonhealing chronic acral lesions such as squamous cell carcinoma or Bowen's disease, eccrine poroma, keratoacanthoma, melanoma, or bacterial, mycotic, and viral infections. 3,7,8 Despite the rarity of palmar BCC and its clinical variability, it must be included in the differential diagnosis of longstanding palmar single lesions. Dermoscopy continues to expand its usefulness in nonpigmented lesions, so the dermoscopic findings of BCCs are well established, however, dotted vessels, ulcers, and absence of arborizing vessels appear to be specific of glabrous skin presentation; hence, we should accumulate dermoscopic descriptions in more such cases. ...
Basal cell carcinoma (BCC) is the most common cutaneous neoplasm, however its spontaneous appearance in palmar glabrous skin is extremely rare with around 21 cases reported in the literature, being its occurrence aberrant due to its known pathogenesis in relation to the hair follicle.
