Figure 2 - Shaping of T Cell Functions by Trogocytosis

Figure 2. Trogocytosis in T cell priming and effector phases. During the priming phase, dendritic cell (DC) type 2 cells (DC2s) present extracellular tumor antigens on MHCII to activate CD4 + T cells whereas DC type 1 cells (DC1s) are able to present them on MHCI, called cross-presentation, to activate CD8 + T cells. In addition, DC1s and/or DC2s acquire preformed antigen-MHCI complexes for antigen presentation to CD8 + T cells, which is called cross-dressing. In the cytotoxic T lymphocyte (CTL) effector phase, CTLs strip off target antigens from tumor cells. These CTLs with acquired tumor antigen-MHCI are then lysed by tumor-unexperienced CTLs through a process called fratricide cell death. On the other hand, tumor cells lose antigens, resulting in generation of CTL escape variants.

Trogocytosis in T cell priming and effector phases. During the priming phase, dendritic cell (DC) type 2 cells (DC2s) present extracellular tumor antigens on MHCII to activate CD4 + T cells whereas DC type 1 cells (DC1s) are able to present them on MHCI, called cross-presentation, to activate CD8 + T cells. In addition, DC1s and/or DC2s acquire preformed antigen-MHCI complexes for antigen presentation to CD8 + T cells, which is called cross-dressing. In the cytotoxic T lymphocyte (CTL) effector phase, CTLs strip off target antigens from tumor cells. These CTLs with acquired tumor antigen-MHCI are then lysed by tumor-unexperienced CTLs through a process called fratricide cell death. On the other hand, tumor cells lose antigens, resulting in generation of CTL escape variants.

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Reference

Shaping of T Cell Functions by Trogocytosis - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Trogocytosis-in-T-cell-priming-and-effector-phases-During-the-priming-phase-dendritic_fig1_351462635 [accessed 17 Jan 2025]

Caption

Figure 2. Trogocytosis in T cell priming and effector phases. During the priming phase, dendritic cell (DC) type 2 cells (DC2s) present extracellular tumor antigens on MHCII to activate CD4 + T cells whereas DC type 1 cells (DC1s) are able to present them on MHCI, called cross-presentation, to activate CD8 + T cells. In addition, DC1s and/or DC2s acquire preformed antigen-MHCI complexes for antigen presentation to CD8 + T cells, which is called cross-dressing. In the cytotoxic T lymphocyte (CTL) effector phase, CTLs strip off target antigens from tumor cells. These CTLs with acquired tumor antigen-MHCI are then lysed by tumor-unexperienced CTLs through a process called fratricide cell death. On the other hand, tumor cells lose antigens, resulting in generation of CTL escape variants.

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<a href="https://www.researchgate.net/figure/Trogocytosis-in-T-cell-priming-and-effector-phases-During-the-priming-phase-dendritic_fig1_351462635"><img src="https://www.researchgate.net/publication/351462635/figure/fig1/AS:1022084343922688@1620695305406/Trogocytosis-in-T-cell-priming-and-effector-phases-During-the-priming-phase-dendritic.png" alt="Trogocytosis in T cell priming and effector phases. During the priming phase, dendritic cell (DC) type 2 cells (DC2s) present extracellular tumor antigens on MHCII to activate CD4 + T cells whereas DC type 1 cells (DC1s) are able to present them on MHCI, called cross-presentation, to activate CD8 + T cells. In addition, DC1s and/or DC2s acquire preformed antigen-MHCI complexes for antigen presentation to CD8 + T cells, which is called cross-dressing. In the cytotoxic T lymphocyte (CTL) effector phase, CTLs strip off target antigens from tumor cells. These CTLs with acquired tumor antigen-MHCI are then lysed by tumor-unexperienced CTLs through a process called fratricide cell death. On the other hand, tumor cells lose antigens, resulting in generation of CTL escape variants."/></a>