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The transition from a balanced (Eubiosis) to an unbalanced (dysbiosis) gut microbiota and the different factors involved in gut dysbiosis. Abbreviations: LPS: lipopolysaccharide; ROS: reactive oxygen species; ↑ increased; ↓ decreased. The figure is developed using https://biorender.com/ (accessed on 12 December 2022).
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Since the gut microbiota plays a pivotal role in host homeostasis and energy balance, changes in its composition can be associated with disease states through the promotion of immune-mediated inflammatory disorders and increasing intestinal permeability, ultimately leading to the impairment of intestinal barrier function. Za’atar is one of the most...
Citations
... As a word, the meanings of Za'atar may differ between regions and cultures. Generally, Za'atar refers to a type of plant, and at the same time to a combination of different plants and spices blended altogether [30,31]. ...
... Particularly in Lebanon and Tunisia, Za'atar refers to many plants belonging to different families called thyme-like plants, including Origanum, Thymus, Thymbra, and Satureja. Those plants are rich in carvacrol and thymol, two isomers of phenolic "monoterpenes" that give the unique smell of these plants [31]. ...
Despite herbal medicine being popular across the Mediterranean basin, there is no evidence in favor of COVID-19 infection. This study investigates the utilization and effects of medicinal plants in Italy, Lebanon, and Tunisia during COVID-19 and its effects on post-COVID-19 pandemics. We used a tailored, web-based “Google Form” questionnaire with the random sampling method. We gathered 812 complete responses (Italy: 116, Lebanon: 557, and Tunisia: 139), revealing diverse demographics and symptom experiences. Fatigue prevailed across all groups (89.0–94.2%), while psychological impacts ranged from 20.1% to 30.9%, with higher rates in Lebanon. Post-COVID-19 symptoms affected 22.4% (Italy), 48.8% (Lebanon), and 31.7% (Tunisia). General use of herbs was consistent (41.4–50.4%), with 23.3% (Italy), 50.2% (Lebanon), and 65.5% (Tunisia) employing herbs for COVID-19 therapy. Notably, in Lebanon, Za’atar, a thyme-like plant, correlated with reduced symptoms, suggesting potential protective effects that are likely due to its polyphenol richness. This study underscores the persistent reliance on traditional medicinal plants remedies in the Mediterranean area, with regional variations. Further exploration of herbal compounds for COVID-19-like symptoms is warranted.
... This approach respects cultural preferences and leverages local agricultural practices and seasonal food availability. For instance, the MD serves as a model for antiinflammatory eating, with potential adaptations including local herbs and spices like saffron and za'atar (305,306) . South Asian diets can be enhanced by incorporating whole grains like barley, quinoa and black rice and promoting fish and plant-based proteins. ...
An anti-inflammatory diet is characterised by incorporating foods with potential anti-inflammatory properties, including fruits, vegetables, whole grains, nuts, legumes, spices, herbs and plant-based protein. Concurrently, pro-inflammatory red and processed meat, refined carbohydrates and saturated fats are limited. This article explores the effects of an anti-inflammatory diet on non-communicable diseases (NCD), concentrating on the underlying mechanisms that connect systemic chronic inflammation, dietary choices and disease outcomes. Chronic inflammation is a pivotal contributor to the initiation and progression of NCD. This review provides an overview of the intricate pathways through which chronic inflammation influences the pathogenesis of conditions including obesity, type II diabetes mellitus, CVD, autoinflammatory diseases, cancer and cognitive disorders. Through a comprehensive synthesis of existing research, we aim to identify some bioactive compounds present in foods deemed anti-inflammatory, explore their capacity to modulate inflammatory pathways and, consequently, to prevent or manage NCD. The findings demonstrated herein contribute to an understanding of the interplay between nutrition, inflammation and chronic diseases, paving a way for future dietary recommendations and research regarding preventive or therapeutic strategies.
... O.syriacum holds significant medicinal importance as it safeguards the integrity of the intestinal mucosal barrier, alleviates abdominal discomfort, and aids in preventing constipation by maintaining proper moisture levels in the stool [46]. The essential oils derived from O.syriacum mainly consist of thymol, γ-terpinene, and carvacrol, and these compounds are responsible for the distinct aroma and flavor associated with the plant [47]. ...
... Origanum essential oil contains abundant antioxidant compounds, such as polyphenols, encompassing phenolic acids and flavonoids. These compounds exhibit diverse biological and pharmacological activities and can hinder the growth of various pathogens, including H. pylori [46]. In addition, plant extracts are involved in managing colds, coughs, and toothaches [49]. ...
... Furthermore, toxicity investigations have demonstrated that the ingestion of this plant does not cause any harmful effects on animals. This quality makes it a compelling natural candidate in the field of drug discovery [46]. ...
Aims of the Study
This study was designed to evaluate the antimicrobial activity of some medicinal plants used among Jordanians for the treatment of gastritis and gastric ulcers against H. pylori. Moreover, plants' inhibitory activity against the H. pylori urease enzyme was also evaluated.
Materials and Methods
The activity of 11 medicinal plants used by common people and herbalists to treat ulcers was evaluated against H. pylori (NCTC 11916). Ethanol and essential oil extracts from the tested plants were evaluated using a standard agar dilution method and the MICs were determined. Furthermore, the potential inhibitory effect of each preparation was tested against the enzyme urease using a kinetic colorimetric assay.
Results
Cinnamomum cassia oil showed the highest efficiency against H. pylori with the lowest MIC (0.0122 mg.mL-1), followed by Origanum syriacum and Foeniculum vulgare (MICs of 0.39 mg.mL-1). Furthermore, significant urease inhibition activity was recorded for Carum carvi oil (IC50~0.45 mg.mL-1). C. cassia oil (IC50 ~2.8 mg.mL-1), Aloysia citriodora, and Artemisia Judaica (IC50 5.8 mg.mL-1) reported potential urease inhibition activities.
Conclusion
Herbs used in Jordanian traditional medicine were found to have anti-H. pylori and significant urease inhibitory activity. These findings might support the use of medicinal plants as adjuvant or alternative therapy for the treatment of H. pylori.
... The mixture contains hundreds of antioxidant compounds, especially polyphenols. Za'atar compounds have been studied from a gastrointestinal perspective, concerning both gut microbiota and gastrointestinal diseases, suggesting that Za'atar polyphenols may provide beneficial effects in the complex interplay between the diet, GM, and intestinal permeability [11]. ...
... This could be useful for the management of pathogenic bacterial overgrowth during dysbiosis, which may occur under different disease conditions. Several studies using cellular or animal models have described the modulatory effects of CVL and CVL-rich essential oils (EOs) on gut microbiota [11]. EOs rich in CVL increased the relative abundance of some beneficial species such as Bacilli, Lactobacillales, and Veillonellaceae in weaned piglets [39], and improved microbiota composition, as well as piglet health and performance [40]. ...
(Poly)phenolic-rich Mediterranean plants such as Thymbra spicata have been associated with several health-promoting effects. The nutritional value, as well as physiological interaction of T. spicata with the gastrointestinal tract, has not been investigated before. The nutritional composition of T. spicata leaves was here characterized by standard analytical methods. T. spicata leaves were subjected to ethanolic extraction, simulated gastrointestinal digestion, and anaerobic microbial gut fermentation. Phenols/flavonoid contents and radical scavenging activity were assessed by colorimetric methods. The volatile organic compounds (VOCs) were detected by gas chromatography coupled with mass spectrometry. The effect on intestinal integrity was evaluated using a Caco-2 monolayers mounted in a Ussing chamber. T. spicata contains a high amount of fiber (12.3%) and unsaturated fatty acids (76% of total fat). A positive change in VOCs including short-chain fatty acids was observed without significant change in viable microbe. T. spicata and carvacrol (main phenolic compound) enhanced ionic currents in a concentration-dependent manner without compromising the Caco-2 monolayer’s integrity. These effects were partially lost upon simulated digestion and completely abolished after colonic fermentation in line with polyphenols and carvacrol content. Conclusion: T. spicata represents a promising nutrient for the modulation of gut microbiota and the gut barrier. Further studies must better define its mechanisms of action.
Several hallmarks of metabolic syndrome, such as dysregulation in the glucose and lipid metabolism, endothelial dysfunction, insulin resistance, low-to-medium systemic inflammation, and intestinal microbiota dysbiosis, represent a pathological bridge between metabolic syndrome and diabesity, cardiovascular, and neurodegenerative disorders. This review aims to highlight some therapeutic strategies against metabolic syndrome involving integrative approaches to improve lifestyle and daily diet. The beneficial effects of foods containing antioxidant polyphenols, intestinal microbiota control, and physical activity were also considered. We comprehensively examined a large body of published articles involving basic, animal, and human studie, as well as recent guidelines. As a result, dietary polyphenols from natural plant-based antioxidants and adherence to the Mediterranean diet, along with physical exercise, are promising complementary therapies to delay or prevent the onset of metabolic syndrome and counteract diabesity and cardiovascular diseases, as well as to protect against neurodegenerative disorders and cognitive decline. Modulation of the intestinal microbiota reduces the risks associated with MS, improves diabetes and cardiovascular diseases (CVD), and exerts neuroprotective action. Despite several studies, the estimation of dietary polyphenol intake is inconclusive and requires further evidence. Lifestyle interventions involving physical activity and reduced calorie intake can improve metabolic outcomes.
Aim:
This research concerns the patentability of carvacrol; it could be helpful for researchers to easily identify any innovation in the biotechnological application of this monoterpene as well as other similar compounds.
Background:
Like thyme or oregano, several plants in the Lamiaceae family produce carvacrol. It is one of the secondary metabolites with several biological activities, including the improvement in plants’ resistance and their protection. Carvacrol has many chemical properties, such as antioxidant and anti-microbial, which have made it interesting for multiple biotechnological applications in the fields of food, feed, pharmacology, and cosmetology.
Objective:
We have made an attempt to demonstrate the value of carvacrol, first by studying quantitative data from patent documents, and then, through some relevant patents, we have tried to highlight the various fields of innovation related to the properties of carvacrol.
Method:
For the study, we have collected and sorted patent documents (i.e., patent applications and granted patents) from specialized patent databases, using “carvacrol” and some of its synonyms as keywords. The selected documents have included these keywords in their titles, abstracts, or claims. Then, thanks to patent analysis, we have tried to provide an overview of the useful properties of organic compounds.
Result:
We have shown that about 90% of the patent documents studied have been published in the 2000s. The number of publications, which is constantly increasing, demonstrates the growing interest in carvacrol. Although the applications of carvacrol are varied, the data on the IPC classification show that most published innovations are concerned with formulations in the fields of health, food, and feed. The study of the most relevant patents has allowed us to highlight some developments in the extraction and synthesis of carvacrol and some examples of patents that illustrate the wide possibilities offered by the exploitation of carvacrol. Thus, we have discussed its use in the cosmetic, pharmaceutical, food, and agricultural fields.
Conclusion:
Carvacrol is a natural compound with beneficial properties. Several applications using this monoterpene have already been patented in different fields. However, the evolution of patentability has grown this past year and revealed the potential of carvacrol in biotechnology.
