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The total synaptic currents (blue line) and membrane action potential (black line). The whole simulation process is divided into five processes. The external stimuli to the cortex are 0.67, 0.8, 0.83, 0.88, and 1 (unit pA) respectively. Each stage is calculated for 2000 ms.
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Basal ganglia (BG) are a widely recognized neural basis for action selection, but its decision-making mechanism is still a difficult problem for researchers. Therefore, we constructed a spiking neural network inspired by the BG anatomical data. Simulation experiments were based on the principle of dis-inhibition and our functional hypothesis within...
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Context 1
... connected all the neurons using the synaptic model described above to perform a network simulation. The evolution of the firing rate of these neurons in response to external stimuli is shown in Figure 2. We tested the dynamics of the information flow in this network and show it in Figure 3. ...
Context 2
... shown in Figure 5(b), the firing rate of GPi/SNr does not increase linearly with the continuous improvement of the activation level of neuronal populations at each stage. The emission rate of GPi/SNr increased rapidly in the pre-group competition stage (Stages-1 and −2), but slowly in the postgroup competition stage (Stages-3 and −4). Even in the intra-group competition, the GPi/SNr activity decreased in the DP and HDP competition stage (Stage-2 to Stage-3). ...
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In this work, inspired by cognitive neuroscience experiments, we propose recurrent spiking neural networks trained to perform multiple target tasks. These models are designed by considering neurocognitive activity as computational processes through dynamics. Trained by input–output examples, these spiking neural networks are reverse engineered to f...
Citations
... Nonlinear dynamics of neuronal electrical behaviors have been extensively studied, which are involved in brain functions or brain diseases (Wang et al. 2021;Wang and Duan 2022;Yu et al. 2022Yu et al. , 2023Li et al. 2023;Song et al. 2023;Yang et al. 2023;Zhou et al. 2023;Ma et al. 2023). For example, the resonance of the medial superior olive (MSO) neurons of the auditory brainstem is related to sound localization (Grothe et al. 2010). ...
Neurons in the medial superior olive (MSO) exhibit high frequency responses such as subthreshold resonance, which is helpful to sensitively detect a small difference in the arrival time of sounds between two ears for precise sound localization. Recently, except for the high frequency depolarization resonance mediated by a low threshold potassium (IKLT) current, a low frequency hyperpolarization resonance mediated by a hyperpolarization-activated cation (IH) current is observed in experiments on the MSO neurons, forming double resonances. The complex dynamics underlying double resonances are studied in an MSO neuron model in the present paper. Firstly, double resonances similar to the experimental observations are simulated as the resting membrane potential is between half-activation voltages of IH and IKLT currents, and stimulation current (IZAP) with large amplitude and exponentially increasing frequency is applied. Secondly, multiple effective factors to modulate double resonances are obtained. Especially, the decrease of time constant of IKLT current and increase of conductance of IH and IKLT currents can enhance the depolarization resonance frequency for precise sound localization. Last, different frequency responses of slow IH and fast IKLT currents in formation of the resonances are acquired. A middle phase difference between IZAP and IKLT currents appears at a high frequency, and the interaction between the positive part of IZAP and the negative IKLT current forms the depolarization resonance. Interaction between the negative part of IZAP and positive IH current with a middle phase difference results in hyperpolarization resonance at a low frequency. Furthermore, the phase difference between IZAP and resonance current can well explain the increase of depolarization resonance frequency modulated by the increase of conductance of IH or IKLT currents. The results present the dynamical and biophysical mechanisms for the double resonances mediated by two currents in the MSO neurons, which is helpful to enhance the depolarization resonance frequency for precise sound localization.
