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The fluidized bed granulation had been investigated based on the experimental design and factorial analysis. The influence of process parameters (above all starch type and method of binder input) on the quality of product had been recognized and the optimal granulation parameters had been found. Four types of cold water soluble binders were used. T...
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... types of water soluble binders were used: native maize starch (Mondamin) and three modified starches such as partially pregelatinized maize starch (Starch 1500, Colorcon®), pregelatinized maize starch (Lycatab® PGS, Roquette), hydrolyzed maize starch (Lycatab® DSH, Roquette). Native maize starch is a traditional binder and is widely used at food industry. Lycatab® PGS is a precooked starch resulting from the physical modification of native maize starch. Starch 1500 has a mixture of properties of both native and pregelatinized starches. It performs the multiple functions of a binder, disintegrant, and flow- aid while having lubricant properties. Lycatab® DSH is obtained through the controlled hydrolysis of native maize starch followed by spray drying. It combines the binding characteristics of starch with the advantage of fast and total solubility in water at room temperature. Lactose powder (Lactochem, Domo) was used as initial material for granulation. The scheme of fluidized bed granulation is presented on Fig. 1. Powders are fluidized and a binder solution is sprayed onto the fluidized particles, creating liquid bridges between particles. Its solidification by ...
