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Figure 5 - Dynamics of transcriptional regulation from total RNA-seq experiments

Figure 5 The role of RNA processing dynamics in the responsiveness of mature RNA. (A) Premature and mature RNA abundances and the value of the RNA kinetic rates for two genes with fast (k 2 =20) and slow (k 2 =0.2) processing dynamics. The corresponding profiles of increased abundance of premature and mature RNA following a doubling in the rate of synthesis (k 1 ) are indicated on the right. (B) Distributions of RNA kinetic rates in untreated 3T9 fibroblast cells. (C) Percentage of genes with reduced responsiveness following the indicated N-fold modulation of the kinetic rate(s). (D) RNA-seq samples are colour-coded according to the corresponding tissue-type and median values of í µí¼ and í µí»¥ for protein-coding RNAs are reported. (E-F) as in (D) for pseudogenes and long non-coding RNAs, respectively.
The role of RNA processing dynamics in the responsiveness of mature RNA. (A) Premature and mature RNA abundances and the value of the RNA kinetic rates for two genes with fast (k 2 =20) and slow (k 2 =0.2) processing dynamics. The corresponding profiles of increased abundance of premature and mature RNA following a doubling in the rate of synthesis (k 1 ) are indicated on the right. (B) Distributions of RNA kinetic rates in untreated 3T9 fibroblast cells. (C) Percentage of genes with reduced responsiveness following the indicated N-fold modulation of the kinetic rate(s). (D) RNA-seq samples are colour-coded according to the corresponding tissue-type and median values of í µí¼ and í µí»¥ for protein-coding RNAs are reported. (E-F) as in (D) for pseudogenes and long non-coding RNAs, respectively.
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