The results of variables in type 2 diabetic patients 

The results of variables in type 2 diabetic patients 

Source publication
Article
Full-text available
Introduction: Elevated cholesterol and blood pressure are major risk factors for the development diabetic kidney disease. Possible interactions between these two parameters have not been studied in detail. Objectives: This investigation aims to study the values of blood serum cholesterol, blood pressure and possible correlations between them, in a...

Similar publications

Article
Full-text available
Importance The association of diabetic microvascular complications such as diabetic retinopathy (DR) and diabetic kidney disease (DKD) with mortality in populations is not clear. Objective To examine the association of DR and DKD separately and jointly with all-cause and cardiovascular disease (CVD) mortality in a multiethnic Asian population. De...
Article
Full-text available
Aim To construct a simple screening tool for predicting diabetic kidney disease in Chinese patients with type 2 diabetes. Materials and Methods In the development cohort, the clinical and procedural characteristics of the 4,795 patients were considered as candidate univariate predictors of diabetic kidney disease. The β-coefficients derived from a...
Article
Full-text available
Diabetic kidney disease (DKD) is a complex, multifactorial disease and is associated with a high risk of renal and cardiovascular morbidity and mortality. Clinical practice guidelines for diabetes recommend essentially identical treatments for all patients without taking into account how the individual responds to the instituted therapy. Yet, indiv...
Article
Full-text available
Elevated resting heart rate (RHR) has been associated with increased risk of mortality and cardiovascular events. Limited data are available so far in type 2 diabetic (T2DM) subjects with no study focusing on progressive renal decline specifically. Aims of our study were to verify RHR as a simple and reliable predictor of adverse disease outcomes i...

Citations

... The plaques then expand inside the arteries due to the growth of fibrous tissues and surrounding smooth muscle, causing blood flow to be reduced. Sclerosis is caused by fibroblasts producing connective tissue and calcium deposits in the lesion [2,28,29]. ...
Article
Full-text available
Cardiovascular diseases (CVDs), the most common cause of mortality in rich countries, include a wide variety of pathologies of the heart muscle and vascular system that compromise the proper functioning of the heart. Most of the risk factors for cardiovascular diseases are well-known: lipid disorders, high serum LDL cholesterol, hypertension, smoking, obesity, diabetes, male sex and physical inactivity. Currently, much evidence shows that: (i) the human microbiota plays a crucial role in maintaining the organism’s healthy status; and (ii) a link exists between microbiota and cardiovascular function that, if dysregulated, could potentially correlate with CVDs. This scenario led the scientific community to carefully analyze the role of the microbiota in response to drugs, considering this the right path to improve the effectiveness of disease treatment. In this review, we examine heart diseases and highlight how the microbiota actually plays a preponderant role in their development. Finally, we investigate pharmacomicrobiomics—a new interesting field—and the microbiota’s role in modulating the response to drugs, to improve their effectiveness by making their action targeted, focusing particular attention on cardiovascular diseases and on innovative potential treatments.
... This was supported by a study conducted by Bhattacharjee et al. [30] that reported that LDL-C levels was significantly correlated with HbA1C in a positive direction among myocardial infarction patients. A study among diabetes patients in Iran found that LDL-C levels was significantly positively correlated with both DBP and SBP [31]. Another study in Poland [32] showed that LDL-C levels and triglycerides levels had a positive correlation with triglycerides in both male and female participants. ...
Article
Full-text available
Background Low-density lipoprotein cholesterol (LDL-C) is one of the most important types of cholesterol and has an impact on health. Certain lifestyle and dietary habits in different populations may leads to increased levels of LDL-C, particularly among those with poor education and economic statuses, such as hill tribe people in Thailand. This study aimed to estimate the prevalence of and determine the factors associated with high LDL-C levels among hill tribe people in northern Thailand. Methods A cross-sectional study was performed to gather information from six main hill tribe populations: Akha, Lahu, Hmong, Yao, Karen, and Lisu. Individuals who were aged over 30 years and living in 30 selected hill tribe villages were invited to participate in the study. A validated questionnaire and 5-mL blood specimens were used to obtain data. Correlation analyses, chi-square tests, t-tests, and logistic regression were used to detect correlations and associations. Results A total of 2552 participants were recruited into the study; 65.9% were females, and 64.1% were aged younger than 60 years old. Approximately 69.6% of participants had abnormal LDL-C levels; 33.6% had above-optimal levels, 24.3% had borderline high levels, 8.0% had high levels, and 3.7% had very high levels. A total of 17.4% of participants had low high-density lipoprotein cholesterol (HDL-C) and high LDL-C levels, while 14.9% had high triglyceride and LDL-C levels. After controlling for sex, age, religion, education, annual family income, and marital status in the multivariate model, three variables were found to be associated with high LDL-C levels: occupation, the amount of lard used in daily cooking, and glycated hemoglobin (HbA1c). Those who were working as agriculturalists had a 1.34-fold greater chance of having abnormal LDL-C than traders and others (95% CI = 1.09–1.34). Those who used moderate and high quantities of lard in their daily cooking had a 1.45-fold (95% CI = 1.15–1.82) and 1.31-fold (95% CI = 1.04–1.68) greater likelihood of having abnormal LDL-C levels than those who used low quantities, respectively. Those who had abnormal HbA1c levels were less likely to develop abnormal LDL-C levels than those who had normal HbA1c levels (AOR = 0.69, 95% CI = 0.51–92). Conclusions Effective public health programs that do not conflict with the cultures of hill tribes are urgently needed, particularly programs encouraging the use of small quantities of lard for daily cooking practices.
... Dyslipidemia is one critical factor which can result in high morbidity and mortality [10]. Consequently, strategies to manage the lipidemic response are of tremendous clinical importance [11,12]. ...
Article
Full-text available
We performed a systematic review and meta-analysis of randomized controlled trials (RCTs) to assess the effects of magnesium (Mg) supplementation on the lipid profile in type 2 diabetes (T2DM) patients. Web of Science, Scopus, PubMed, and Embase databases were searched to infinity until 30 January 2020. Weighted mean differences (WMD) were pooled using a random-effects model. Heterogeneity, sensitivity analysis, and publication bias were reported using standard methods. The pooled analysis of 12 randomized controlled trials indicated that Mg administration led to significant reduction of serum low-density lipoprotein (LDL) levels (p = 0.006). However, our results revealed that Mg supplementation did not have any effect on triglycerides (TG), total cholesterol (TC), and high-density lipoprotein (HDL) serum concentrations among T2DM patients in comparison with the control group. Subgroup analysis based on duration of study suggested that more than 12 weeks of Mg supplementation significantly decreased the serum TC levels (p = 0.002). Subgroup analysis comparing the dose of intervention indicated that Mg supplementation less than 300 mg significantly decreased the serum LDL concentrations (p < 0.001), while more than 300 mg of Mg supplementation significantly increased the serum HDL levels (p = 0.026). In a subgroup analysis comparing the type of intervention, it displayed that inorganic Mg supplementation decreased the LDL (p < 0.001) and TC (p = 0.003) levels, while organic Mg supplementation showed no difference. Mg supplementation has a beneficial effect on lowering LDL level in T2DM patients. However, we have to note that any research performed so far is not sufficient for making robust guidelines to use Mg supplementation in clinical practice.
... 6,7 But, other study stated that there is no relationship between dyslipidemia and systolic nor diastolic blood pressure. 8 In Kalidoni Primary Health Center (Puskesmas), hypertension is on the second tier of disease prevalence, consisting of 6.406 cases according to Kalidoni Primary Health Center Profile in 2019. In this healthcare facility, only 38% of patients are adequately treated according to the minimum care standard that is also oriented to controlled lipid profiles. ...
Article
Full-text available
Background: Hypertension is the main problem worldwide. It has strong relationship with other component of metabolic syndrome, namely dyslipidemia. The research objective is to analyze the correlation between total cholesterol level and blood pressure in the hypertensive patient at Kalidoni Primary Health Center, Palembang, Indonesia. Methods: This was a cross-sectional study involving 82 adult hypertensive patients. Data were collected from the medical record of patients who are visiting Kalidoni Primary Health Center in December 2019-January 2020. Demographic data, blood pressure, and total cholesterol level were gained. Obtained data are analyzed descriptively (frequency distribution) and analytically (correlation using Pearson or Spearman method). Result: Significant positive correlations were observed between total cholesterol level and systolic blood pressure (r=0.509, p=0.000) in addition to body weight and diastolic blood pressure (r=0.279; p=0.011). Conclusion: Blood cholesterol level had a significant correlation with moderate strength for determining systolic blood pressure level in hypertensive patients.
... Hemodialysis patients are more susceptible to oxidative stress. This disease reduces vasodilatation and increases oxidative stress and endothelial toxicity [42,43]. Weinstein also reported a low level of GSH in hemodialysis patients. ...
... It was revealed in hypothesis testing that Diastolic Blood Pressure (DBP) has a significant association with HPT and CHD. A group of researchers have associated DBP with HPT (Behradmanesh & Nasri, 2012;Tringali & Huang, 2017;Wang et al., 2015) and DBP with to CHD (e.g. Drozdz & Kawecka-Jaszcz, 2014;Franklin et al., 2001;Lichtenstein, Shipley, & Rose, 1985;Shu et al., 2013;Tsujimoto & Kajio, 2018). ...
Article
Full-text available
This research is an application of machine learning in medical sciences. The purpose of this research was to use machine learning through the simulated data to study the association of age, body mass index, cigarettes smoked per day, alcohol consumed per week, diastolic blood pressure, and systolic blood pressure on hypertension and coronary heart disease. The Structural Equation Modelling using Partial Least Square Method was used for the analysis of data. The results have revealed that except for age, body mass index and systolic blood pressure all the rest of the factors had a significant positive association with hypertension and coronary heart disease. The results can be of use for medical practitioners as well as researchers in machine learning, as it adds to the repository of earlier studies, which have attempted to seek relationships between these variables.
... It also involves hemodynamic factors like various vasoactive hormones, such as components of the renin system -angiotensin. These factors contribute to the pathological damage of the glomerulus and tubulointerstitium [8]. ...
Article
Full-text available
Background: Diabetes is a metabolic pathology that affects the human body's capacity to adequately produce and use insulin. Type 1 (insulin-dependent) diabetes accounts for 5-10 % of diabetic patients. In Type 2 diabetes the insulin produced by the pancreatic islets is not properly used by cells due to insulin resistance. Gestational diabetes sometimes occurs in pregnant women and affects about 18 % of all pregnancies.Diabetes is one of the most important multifactorial metabolic chronic diseases with fatal complications. According to the International Diabetes Federation's estimations in 2015, 415 million people had diabetes and there will be an increase to 642 million people by 2040. Although many ethnopharmacological surveys have been carried out in several parts of the world, no ethnomedical and ethnopharmacological surveys have been done to identify plants used for the prevention and treatment of diabetes. Objective: This study aimed to collect and document information on food plants' remedies consumed for the prevention and treatment of diabetes in Cameroon. Methods: Ethnomedical and ethnopharmacological thorough preparations were conducted with 1131 interviewees from 58 tribes, following a random distribution. Diabetic patients recorded among this sample signed the informed consent and allowed us to evaluate the effectiveness of 10 identified food plants usually used for self-medication. They were divided into two groups: Group 1 comprised of 42 diabetic patients who regularly consume certain of these food plants, and Group 2 included 58 patients who were town-dwellers and did not regularly eat these identified food plants. Results: It was recorded that the onset of diabetes in patients were at about 70 years and 45 years for Group 1 and Group 2 respectively. Hence, a relationship was demonstrated between the onset of diabetes and the consumption of food plants. They contributed to the prevention and/or the delay in clinical manifestations. Conclusion: Further investigations and/or clinical trials involving a large number of both type 1 and type 2 diabetics are needed to describe the therapeutic action of many food plants against diabetes. However, this study provides scientific support for the use of herbal medicines in the management of diabetes.
... Animal temperature was kept at 37°C with a heating lamp. The left femoral artery was cannulated with a polyethylene catheter (PE-50) filled with heparinized saline then catheter connected to a blood pressure transducer and blood pressure (BP) and heart rate [20] continuously recorded by a power lab system (ID instrument, Australia) [21]. ...
... Rats randomly divided into 5 groups which are as follows (n = 7 in each group): 1) sham group that femoral artery cannulated and cardiovascular parameters recorded, 2) saline group that received vehicle (saline) for 4 weeks after that cardiovascular parameters recorded, 3-5) Z.J groups that rats separately treated by three doses of hydroalcoholic extract of Z.J (100, 200 and 400 mg/kg) [22] by gavage for four weeks after that the cardiovascular parameters recorded. In a day of experiment (28 th day) Systolic Blood Pressure (SBP), Mean Atrial Pressure (MAP) and Heart Rate (HR) [20] in all groups were recorded throughout the experiment. The weight of animal in all groups was also recorded in the beginning and the last days of experiment. ...
Article
Objective Ziziphus jujuba (Z.J) is a medicinal plant with several properties such as antioxidant, antibacterial, hypnotic and wound healing activity. It also has lowering blood pressure effect and people use it to treat hypertension. In the present study, the effect of hydroalcoholic extract of Z.J on cardiovascular parameters in the normotensive rats was investigated. Methods Animal groups include: 1) Sham, only cannulation of artery 2) saline, received saline for four weeks 3-5) Z.J groups (100, 200 and 400 mg/kg) that treated with Z.J via gavage for four weeks. In the experiment day (28th Day) femoral artery of all rats cannulated and Systolic Blood Pressure (SBP), Mean Atrial Pressure (MAP) and Heart Rate (HR) recorded by a power lab system. The weight of animal in all groups also was recorded in the beginning and the last day of experiment. Results There was no significant difference in HR, SBP and MAP parameters between sham and control groups. The SBP and MAP in higher doses of Z.J (200 and 400 mg) significantly decreased compared to control group. The HR only in dose 200 mg of Z.J significantly decreased than the control group. Conclusion The results of present study show that hydroalcoholic extract of Z.J has an inhibitory effect on basal cardiovascular parameters and its best effects have been shown in dose 200 mg/kg.
... However, chronic oxidative stress occurs when obesity is associated with hypertension [47][48][49]. Hypertension is a common risk factor for cardiovascular disease including myocardiac infarction, stroke, chronic kidney diseases and metabolic abnormalities [49][50][51]. These can lead to reduction in individual life span if appropriate health interventions are not in place [49,50]. ...
... Hypertension is a common risk factor for cardiovascular disease including myocardiac infarction, stroke, chronic kidney diseases and metabolic abnormalities [49][50][51]. These can lead to reduction in individual life span if appropriate health interventions are not in place [49,50]. It has been established that oxidative stress plays a major role in the pathogenesis of hypertension [52,53]. ...
... Hypertension is a major health problem and predominant risk factor for the occurrence of numerous diseases, including heart failure, myocardial infarction, stroke and peripheral arterial disease (1,2). Hypertension is capable of promoting arterial remodeling, which is an adaptive process that occurs in response to long-term alterations in the hemodynamic condition of hypertension, predominantly including vessel wall thickening and histological abnormalities, hemal wall/lumen ratio increases and endothelial dysfunction (3). ...
Article
Arterial remodeling is a pathogenic occurrence during hypertension and, in turn, is closely associated with the development and complications of hypertension. Grape seed proanthocyanidin extract (GSPE) has been reported to exhibit a protective effect on cardiovascular disease, however its effect on arterial remodeling remains to be fully elucidated. In the present study, the effects of GSPE on arterial remodeling were analyzed by treating spontaneously hypertensive rats (SHRs) with GSPE (250 mg/kg·day). Arterial remodeling was quantified through morphological methods; thoracic aortas were stained with hematoxylin-eosin or sirius red‑victoria blue. The arterial ultrastructure was imaged using transmission electron microscopy. The content of nitric oxide (NO) and endothelin‑1 (ET‑1) were examined to determine endothelial function. Oxidative stress was assessed by malondialdehyde (MDA) levels and the activities of the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). Administration of GSPE markedly alleviated hypertension‑induced arterial remodeling, which was not associated with blood pressure control. ET‑1 production was reduced, while NO production was increased in the GSPE group, which exhibited improved endothelial function. In addition, treatment with GSPE significantly ameliorated oxidative stress by improving SOD and CAT activities and reducing MDA formation. In conclusion, GSPE may attenuate hypertension‑induced arterial remodeling by repressing oxidative stress and is recommended as a potential anti‑arterial remodeling agent for patients with hypertensive vascular diseases.