The relative content of IgA (a), IgG (b), and IgM (c) in CIC-containing particles was significantly differently expressed between RA and control CIC. The distribution of particle size is based on light scattered intensity. Immunoglobulin levels are determined by dot blot. Data are mean ± SD. Pink squares show particles which exhibited higher prevalence within RA CICs; blue squares show particles which showed higher prevalence within the control CICs. The ↑↓change in the IgA, IgG, and IgM level represents the ratio of mean values of the corresponding immunoglobulin class level in RA and control CICs. All—represents the increase in IgA, IgG, and IgM levels in all analyzed RA CICs compared to all control CICs. A statistically significant difference in immunoglobulin level between RA and control CICs is shown with horizontal bars. The numerical data for this figure are given in Supplementary Materials, Table S7a–c.