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| The relationships between the percentage of MHC-1 and 3-hydroxyacyl-CoA dehydrogenase activity (HAD, n = 10) (A); citrate synthase activity (CS, n = 9) (B); and relative capacity to oxidize fat (HAD/CS ratio) (C). The open circles depict data for the arms and the leg black squares for the legs. For the arm and leg combined, there was a significant correlation between the MHC-1 content and HAD activity (r 2 = 0.32, P = 0.011), as well as the HAD/CS ratio (r 2 = 0.27, P = 0.021).

| The relationships between the percentage of MHC-1 and 3-hydroxyacyl-CoA dehydrogenase activity (HAD, n = 10) (A); citrate synthase activity (CS, n = 9) (B); and relative capacity to oxidize fat (HAD/CS ratio) (C). The open circles depict data for the arms and the leg black squares for the legs. For the arm and leg combined, there was a significant correlation between the MHC-1 content and HAD activity (r 2 = 0.32, P = 0.011), as well as the HAD/CS ratio (r 2 = 0.27, P = 0.021).

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As one of the most physically demanding sports in the Olympic Games, cross-country skiing poses considerable challenges with respect to both force generation and endurance during the combined upper- and lower-body effort of varying intensity and duration. The isoforms of myosin in skeletal muscle have long been considered not only to define the con...

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... maximal CS activity of well-trained arm and leg muscles was the same (Table 2), despite the higher MHC-1 content of the legs, thus demonstrating a non-MHC-dependency in the CS activity. In contrast, the maximal activity of the key enzyme in the ß- oxidation, HAD, was 52% higher (P < 0.05) in the leg compared to arm muscles. Accordingly, the ratio between the HAD and CS activity was 45% higher in leg than arm (1.22 in the leg and 0.86 in arm, P < 0.01), suggesting a relatively higher capacity for lipid oxidation in leg muscle. Further, there was no association between CS activity and MHC distribution (Figure 2A). Thus, CS activity in these highly trained muscles is not associated with the MHC distribution. In contrast, MHC-1 content was a robust predictor of HAD capacity (P = 0.011, r 2 = 0.32, Figure 2B). In line with this, there was also a strong correlation between HAD/CS ratio and the MHC-1 content (P = 0.021, r 2 = 0.27), with no association in trained leg ( Figure 2C). Taken together, in these highly trained skiers, there is a close association between MHC distribution and both absolute (HAD) and relative (HAD/CS) capacity to oxidize fat, with no association between CS capacity and MHC ...
Context 2
... maximal CS activity of well-trained arm and leg muscles was the same (Table 2), despite the higher MHC-1 content of the legs, thus demonstrating a non-MHC-dependency in the CS activity. In contrast, the maximal activity of the key enzyme in the ß- oxidation, HAD, was 52% higher (P < 0.05) in the leg compared to arm muscles. Accordingly, the ratio between the HAD and CS activity was 45% higher in leg than arm (1.22 in the leg and 0.86 in arm, P < 0.01), suggesting a relatively higher capacity for lipid oxidation in leg muscle. Further, there was no association between CS activity and MHC distribution (Figure 2A). Thus, CS activity in these highly trained muscles is not associated with the MHC distribution. In contrast, MHC-1 content was a robust predictor of HAD capacity (P = 0.011, r 2 = 0.32, Figure 2B). In line with this, there was also a strong correlation between HAD/CS ratio and the MHC-1 content (P = 0.021, r 2 = 0.27), with no association in trained leg ( Figure 2C). Taken together, in these highly trained skiers, there is a close association between MHC distribution and both absolute (HAD) and relative (HAD/CS) capacity to oxidize fat, with no association between CS capacity and MHC ...
Context 3
... maximal CS activity of well-trained arm and leg muscles was the same (Table 2), despite the higher MHC-1 content of the legs, thus demonstrating a non-MHC-dependency in the CS activity. In contrast, the maximal activity of the key enzyme in the ß- oxidation, HAD, was 52% higher (P < 0.05) in the leg compared to arm muscles. Accordingly, the ratio between the HAD and CS activity was 45% higher in leg than arm (1.22 in the leg and 0.86 in arm, P < 0.01), suggesting a relatively higher capacity for lipid oxidation in leg muscle. Further, there was no association between CS activity and MHC distribution (Figure 2A). Thus, CS activity in these highly trained muscles is not associated with the MHC distribution. In contrast, MHC-1 content was a robust predictor of HAD capacity (P = 0.011, r 2 = 0.32, Figure 2B). In line with this, there was also a strong correlation between HAD/CS ratio and the MHC-1 content (P = 0.021, r 2 = 0.27), with no association in trained leg ( Figure 2C). Taken together, in these highly trained skiers, there is a close association between MHC distribution and both absolute (HAD) and relative (HAD/CS) capacity to oxidize fat, with no association between CS capacity and MHC ...
Context 4
... maximal CS activity of well-trained arm and leg muscles was the same (Table 2), despite the higher MHC-1 content of the legs, thus demonstrating a non-MHC-dependency in the CS activity. In contrast, the maximal activity of the key enzyme in the ß- oxidation, HAD, was 52% higher (P < 0.05) in the leg compared to arm muscles. Accordingly, the ratio between the HAD and CS activity was 45% higher in leg than arm (1.22 in the leg and 0.86 in arm, P < 0.01), suggesting a relatively higher capacity for lipid oxidation in leg muscle. Further, there was no association between CS activity and MHC distribution (Figure 2A). Thus, CS activity in these highly trained muscles is not associated with the MHC distribution. In contrast, MHC-1 content was a robust predictor of HAD capacity (P = 0.011, r 2 = 0.32, Figure 2B). In line with this, there was also a strong correlation between HAD/CS ratio and the MHC-1 content (P = 0.021, r 2 = 0.27), with no association in trained leg ( Figure 2C). Taken together, in these highly trained skiers, there is a close association between MHC distribution and both absolute (HAD) and relative (HAD/CS) capacity to oxidize fat, with no association between CS capacity and MHC ...
Context 5
... maximal CS activity of well-trained arm and leg muscles was the same (Table 2), despite the higher MHC-1 content of the legs, thus demonstrating a non-MHC-dependency in the CS activity. In contrast, the maximal activity of the key enzyme in the ß- oxidation, HAD, was 52% higher (P < 0.05) in the leg compared to arm muscles. Accordingly, the ratio between the HAD and CS activity was 45% higher in leg than arm (1.22 in the leg and 0.86 in arm, P < 0.01), suggesting a relatively higher capacity for lipid oxidation in leg muscle. Further, there was no association between CS activity and MHC distribution (Figure 2A). Thus, CS activity in these highly trained muscles is not associated with the MHC distribution. In contrast, MHC-1 content was a robust predictor of HAD capacity (P = 0.011, r 2 = 0.32, Figure 2B). In line with this, there was also a strong correlation between HAD/CS ratio and the MHC-1 content (P = 0.021, r 2 = 0.27), with no association in trained leg ( Figure 2C). Taken together, in these highly trained skiers, there is a close association between MHC distribution and both absolute (HAD) and relative (HAD/CS) capacity to oxidize fat, with no association between CS capacity and MHC ...
Context 6
... maximal CS activity of well-trained arm and leg muscles was the same (Table 2), despite the higher MHC-1 content of the legs, thus demonstrating a non-MHC-dependency in the CS activity. In contrast, the maximal activity of the key enzyme in the ß- oxidation, HAD, was 52% higher (P < 0.05) in the leg compared to arm muscles. Accordingly, the ratio between the HAD and CS activity was 45% higher in leg than arm (1.22 in the leg and 0.86 in arm, P < 0.01), suggesting a relatively higher capacity for lipid oxidation in leg muscle. Further, there was no association between CS activity and MHC distribution (Figure 2A). Thus, CS activity in these highly trained muscles is not associated with the MHC distribution. In contrast, MHC-1 content was a robust predictor of HAD capacity (P = 0.011, r 2 = 0.32, Figure 2B). In line with this, there was also a strong correlation between HAD/CS ratio and the MHC-1 content (P = 0.021, r 2 = 0.27), with no association in trained leg ( Figure 2C). Taken together, in these highly trained skiers, there is a close association between MHC distribution and both absolute (HAD) and relative (HAD/CS) capacity to oxidize fat, with no association between CS capacity and MHC ...

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