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The numbers of Norway rats tissue samples received and analysed and their status of resistance or susceptibility. (See Table 1 for further explanations of the different resistance mutations.)
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SUMMARY
1. New resistance data are presented for tissue samples from Norway rats (Rattus norvegicus) and house mice (Mus musculus) collected in the period September 2018 to September 2019. Particular efforts were made to obtain samples in geographical areas in the UK from which none had been collected in the past.
2. A total of 140 Norway rat tiss...
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Context 1
... the period September 2018 and September 2019 a total of 140 Norway rat tissue samples was received that were capable of analysis using the gene sequencing technique. Among these, 85 were found to possess one of the five known Norway rat resistance mutations and 55 were found to be susceptible animals (Table 2). Hence, 60.7% of the samples received possessed one of the resistance mutations, in either their homozygous or heterozygous form. ...Citations
... Ранее этой мутации там не находили. Напротив, в Манчестере резистентность к антикоагулянтам у серых крыс не была найдена [22]. Это представляет собой пример генетической адаптации серых крыс к действию антикоагулянтов в очень большом количестве использующихся в мегаполисе с целью уничтожения грызунов. ...
The resistance of house mice (M. musuclus linnaeus, 1758) and norway rats (R. norvegicus berkenhout, 1769) to anticoagulants of the 1st and 2nd generation in the VKORC1 gene in Moscow and the Moscow region was studied. House mice had two previously unknown mutations in exon 1: Lys175Arg и Ser94Trp. We assume that these mutations can increase the resistance of rodents to second-generation anticoagulants. the percentage of individuals with mutations in exon 1 in Moscow is 87.5 %, in Noginsk and Podolsk – 100 %. Of the 18 norway rats studied in Moscow, only three individuals in a heterozygous state were found to have one of the mutations (Tyr139Ser), usually associated with genetic resistance of rodents to the first generation anticoagulant warfarin. the percentage of resistant individuals in Moscow was 15.7 %. the rats in which the resistance mutation was found were captured in three districts of moscow: southwestern, northern and eastern.
