- The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application

Skin exposed to β-caryophyllene or oil. (A) Six weeks after the application of β-caryophyllene for five days. The wound bed (WB) lacks scar formation compared to the clear scar in the oil group control. Hematoxylin and eosin (H&E) staining. (B) Cell proliferation (bromodeoxyuridine (BrdU)+ cells) (green) was higher in the dermis and epidermis of skin post-wound day 4 exposed to β-caryophyllene compared to the Oil group control. BrdU was injected twice, every two hours, and the skin was harvested four hours after the first injection. OW 400–800: out of wound bed, 400 to 800 um. (C) LGR5 (red) expression was stronger in the skin post-wound day 4 exposed to β-caryophyllene, compared to oil group control (from [2]). The dotted line indicates the wound edge. WB: wound bed.

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The Effects of Essential Oils and Terpenes in Relation to Their Routes of Intake and Application - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/Skin-exposed-to-b-caryophyllene-or-oil-A-Six-weeks-after-the-application-of_fig3_339488481 [accessed 19 Apr 2025]

Caption

Skin exposed to β-caryophyllene or oil. (A) Six weeks after the application of β-caryophyllene for five days. The wound bed (WB) lacks scar formation compared to the clear scar in the oil group control. Hematoxylin and eosin (H&E) staining. (B) Cell proliferation (bromodeoxyuridine (BrdU)+ cells) (green) was higher in the dermis and epidermis of skin post-wound day 4 exposed to β-caryophyllene compared to the Oil group control. BrdU was injected twice, every two hours, and the skin was harvested four hours after the first injection. OW 400–800: out of wound bed, 400 to 800 um. (C) LGR5 (red) expression was stronger in the skin post-wound day 4 exposed to β-caryophyllene, compared to oil group control (from [2]). The dotted line indicates the wound edge. WB: wound bed.

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<a href="https://www.researchgate.net/figure/Skin-exposed-to-b-caryophyllene-or-oil-A-Six-weeks-after-the-application-of_fig3_339488481"><img src="https://www.researchgate.net/publication/339488481/figure/fig3/AS:11431281386865811@1745092073703/Skin-exposed-to-b-caryophyllene-or-oil-A-Six-weeks-after-the-application-of.tif" alt="Skin exposed to β-caryophyllene or oil. (A) Six weeks after the application of β-caryophyllene for five days. The wound bed (WB) lacks scar formation compared to the clear scar in the oil group control. Hematoxylin and eosin (H&E) staining. (B) Cell proliferation (bromodeoxyuridine (BrdU)+ cells) (green) was higher in the dermis and epidermis of skin post-wound day 4 exposed to β-caryophyllene compared to the Oil group control. BrdU was injected twice, every two hours, and the skin was harvested four hours after the first injection. OW 400–800: out of wound bed, 400 to 800 um. (C) LGR5 (red) expression was stronger in the skin post-wound day 4 exposed to β-caryophyllene, compared to oil group control (from [2]). The dotted line indicates the wound edge. WB: wound bed."/></a>