The leaves and stems of Tinospora crispa

The leaves and stems of Tinospora crispa

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Tinospora crispa Miers (Menispermaceae) is a climbing vine with stems rich in warts. The plant is called Akar Seruntum or Patawali in Malaysia and is widely used for treating skin complaints, malaria, bacterial abscess, high blood pressure and diabetes. In the present study, the stems of T. crispa were collected from the locality and succesively ex...

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... crispa, Miers (Figure 1) is one of the essential plants used in traditional medicine throughout Southeast Asian countries. In fact, the genus (Tinospora) is widely used in most areas in Asia and Africa [1]. ...

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... The crude dichloromethane extract of the aerial parts of Euphorbia retusa was subjected to repeated column chromatography and gave two new tetracyclic triterpene-type tirucallane 1a and 1b along with nine known secondary metabolites including six triterpenoids 2-7 and three phenylpropanoid derivatives 8-10 (Fig. 1). The known compounds were identified as euphol 2 (Oliveira Silva et al., 2018), cycloartenol 3 (Teresa et al., 1987), 24-methylenecycloartanol 4 (Haba et al., 2007), 24-methylenecycloartanyl acetate 5 (Teresa et al., 1987), 24-methylenecycloartanyl palmitate 6 (Saif-Eldin, 1994), β-sitosterol 7 (Lan et al., 2020), n-tetracosyl trans-ferulate 8 (Bakhari et al., 2019), n-hexacosyl trans-ferulate 9 (Abbas et al., 2004) and n-octacosyl trans-ferulate 10 (Liu et al., 2001), by comparison of their NMR spectra and values of [α] D with published data. ...
Article
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... Stems (Choudhary et al. 2010a) 46 N-acetylnornuciferine Stems (Pachaly et al. 1992;Bakhari et al. 2005Bakhari et al. , 2013Lin 2009) 47 N-demethyl-N- Enzyme inhibitory assay (Hamid et al. 2015) 63 N-cis-feruloyltyramine ...
... Alkaloids reported from T. crispa mostly originated from the structural extension of the basic isoquinoline skeleton. Thirteen aporphine alkaloids (39-51) have been isolated from different parts of T. crispa ( Fig. 3) (Pachaly et al. 1992;Bakhari et al. 2005Bakhari et al. , 2013Sunthikawinsakul 2005;Imphanban et al. 2009;Choudhary et al. 2010a;Hamid 2013;Yusoff et al. 2014;Hamid et al. 2015;Ahmad et al. 2018;Parveen et al. 2019). Five protoberberine-type alkaloids (52-56) have also been reported (Yusoff et al. 2014;Hamid et al. 2015Hamid et al. , 2021Syarifah et al. 2017;Rahman et al. 2020). ...
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Tinospora crispa (L.) Hook. f. & Thomson (Menispermaceae) is a plant indigenous to Africa and South-East Asia. It is widely used in ethnomedicine to alleviate various diseases including hypertension, diabetes, rheumatism, jaundice, inflammation, fever, fractures, scabies, and urinary disorders. A total of 167 phytoconstituents, belonging to 12 different chemical categories, including alkaloids, flavonoids, terpenoids, and phenolic compounds have thus far been isolated from various parts of T. crispa. Numerous in vitro and in vivo investigations have already established the antidiabetic, anticancer, antiparasitic, antimicrobial, immunomodulatory, hepatoprotective, analgesic, antipyretic, antihyperuricemic, and pesticidal activity of this plant, as well as its effects on the cardiac and the central nervous system. Most pharmacological investigations to date have been carried out on plant extracts and fractions. The exact identity of the phytoconstituents responsible for the observed biological effects and their mode of action at the molecular level are yet to be ascertained. Toxicological studies have demonstrated that T. crispa is relatively safe, although dose-dependent hepatotoxicity is a concern at high doses. This review presents a comprehensive update and analysis on studies related to the ethnomedicinal uses, phytochemistry, pharmacological activity and toxicological profile of T. crispa. It provides some critical insights into the current scientific knowledge on this plant and its future potential in pharmaceutical research.
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