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The genus Ajuga (Lamiaceae family) comprises approximately 300 species, which are widely used in traditional medicine for their diaphoretic, antiseptic, hemostatic, and anti-inflammatory properties, but scarcely in official ones. Therefore, the study of Ajuga reptans holds promise for developing new medicinal products. In aqueous and aqueous-alcoho...
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... quantitative content of the main groups of BAS in the studied extracts was determined. The content of vitamin K1, recalculated as Vikasol, and other phenolic compounds in the extracts of the A. reptans herb, determined by the spectrophotometric method, are presented in Table 1 Using TLC and high-performance liquid chromatography (HPLC), 20 phenolic compounds and quinic acid were identified and quantified in the extracts of the A. reptans herb ( Table 1, Figures 2 and S1). Among phenolic compounds, there were three phenol carboxylic acids, five hydroxycinnamic acids, eight flavonoids, and four tannin metabolites. ...Context 2
... quantitative content of the main groups of BAS in the studied extracts was determined. The content of vitamin K1, recalculated as Vikasol, and other phenolic compounds in the extracts of the A. reptans herb, determined by the spectrophotometric method, are presented in Table 1 Using TLC and high-performance liquid chromatography (HPLC), 20 phenolic compounds and quinic acid were identified and quantified in the extracts of the A. reptans herb ( Table 1, Figures 2 and S1). Among phenolic compounds, there were three phenol carboxylic acids, five hydroxycinnamic acids, eight flavonoids, and four tannin metabolites. ...Context 3
... phenolic compounds, there were three phenol carboxylic acids, five hydroxycinnamic acids, eight flavonoids, and four tannin metabolites. The research results presented in Table 1 indicate that among the identified hydroxycinnamic compounds, the dominant ones were p-coumaric and caffeic acids. Among the flavonoids, the predominant compounds were rutin and quercetin. ...Context 4
... the phenolic compounds in the A. reptans extracts (Table 1), eight flavonoids were identified: rutin, quercetin, quercetin-3-glucoside, luteolin, apigenin, neohesperidin, naringin, and naringenin. The flavonoids mentioned in Table 1 include four aglycones and four glycosides, but quantitatively, there are more glycosides than aglycones, which are responsible for biological activity [31]. ...Context 5
... the phenolic compounds in the A. reptans extracts (Table 1), eight flavonoids were identified: rutin, quercetin, quercetin-3-glucoside, luteolin, apigenin, neohesperidin, naringin, and naringenin. The flavonoids mentioned in Table 1 include four aglycones and four glycosides, but quantitatively, there are more glycosides than aglycones, which are responsible for biological activity [31]. ...Citations
... For example, the activity of Gentamicin against Staphylococci ranged from 10 to 28 mm, Escherichia coli showed an activity of 22 mm, and Escherichia fergusonii exhibited 12 mm. The activity of Fluconazole against yeast-like fungi of the genus Candida reached 19-20 mm [51]. ...
Species of the genus Eryngium L. of the Apiaceae family are successfully used in folk medicine in various countries worldwide, but they are hardly implemented in official medicinal and pharmaceutical practices. Therefore, it is advisable to conduct phytochemical and pharmacological research in E. planum L. herb extracts to develop and implement new phytomedicines based on this raw material. Purified water, and 40% and 70% ethanol were used for obtaining soft extracts. A total of seven hydroxycinnamic acids, six flavonoids, and three tannin metabolites were identified and quantified in the E. planum extracts by HPLC. These extracts were characterized as practically non-toxic medicines (V toxicity class, LD50 > 5000 mg/kg). The hepatoprotective activity of the E. planum extracts has been established. They were affected to reduce serum thiobarbituric acid (TBA) levels by 29.3%, 31.5%, and 32.4%, respectively, compared to untreated animals and in liver homogenate by 59.5%, 65.4%, and 66.8%, respectively. The alanine transaminase (ALT) activity decreased by 26.9%, 30.8%, and 33.8%, respectively. The aspartate transaminase (AST) activity decreased by 23.9%, 25.7%, and 30.5%, respectively. The sedative activity of E. planum extracts was studied for the first time. The 70% ethanol extract has the most pronounced sedative effect due to a significant decrease in motor activity (by 2.4 times compared to the control group) in the «Open Field test» and reduction in concern in the «Cube tests», «Raised Cross Maze», and “Black and White Camera”. This extract also demonstrates a moderate antibacterial effect against gram-positive microorganisms (8–10 mm), including staphylococci, streptococci, and bacilli. These results provide a foundation for further preclinical and clinical studies of the dry extract of E. planum herb (extractant: 70% ethanol) to integrate it into modern medical practice and develop new supplements.
