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1. The central dogma of molecular biology. The genetic information encoded in the DNA is first transcribed into the mRNA, which is then translated into the protein.

1. The central dogma of molecular biology. The genetic information encoded in the DNA is first transcribed into the mRNA, which is then translated into the protein.

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Thesis
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Systems pharmacology aims to transform large-scale heterogenous clinical and biological data into actionable therapeutic strategies. This thesis develops practical machine learning frameworks that contribute to different aspects of systems pharmacology, including the determination of therapeutic drug targets for complex diseases through genome-wide...

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Parkinson’s Disease (PD) is a neurodegenerative disorder with highly heterogeneous phenotypes. Accordingly, it has been challenging to robustly identify genetic factors associated with disease risk, prognosis and therapy response via genome-wide association studies (GWAS). In this review we first provide an overview of existing statistical methods...