Figure 6 - Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets

Figure 6. The cellular and molecular targets of lignans. Flaxseed lignans have the ability to target multiple pathways in cancer given the evidence from both in vitro and in vivo evaluations (Table 2). Cancer metastases can be inhibited by the modulation of the cytoskeleton and cell motility processors. Modulation of cell growth and differentiation as well as cell cycle arrest interfere with tumor proliferation and survival. Starving tumors by targeting angiogenesis as well as triggering apoptosis leads to inhibition of progression and survival. Interfering with different cell signaling pathways linking AKT and ERK modulates cell metabolism and disfavors progression and survival.

The cellular and molecular targets of lignans. Flaxseed lignans have the ability to target multiple pathways in cancer given the evidence from both in vitro and in vivo evaluations (Table 2). Cancer metastases can be inhibited by the modulation of the cytoskeleton and cell motility processors. Modulation of cell growth and differentiation as well as cell cycle arrest interfere with tumor proliferation and survival. Starving tumors by targeting angiogenesis as well as triggering apoptosis leads to inhibition of progression and survival. Interfering with different cell signaling pathways linking AKT and ERK modulates cell metabolism and disfavors progression and survival.

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Reference

Flaxseed Lignans as Important Dietary Polyphenols for Cancer Prevention and Treatment: Chemistry, Pharmacokinetics, and Molecular Targets - Scientific Figure on ResearchGate. Available from: https://www.researchgate.net/figure/The-cellular-and-molecular-targets-of-lignans-Flaxseed-lignans-have-the-ability-to_fig5_332997420 [accessed 28 Mar 2025]

Caption

Figure 6. The cellular and molecular targets of lignans. Flaxseed lignans have the ability to target multiple pathways in cancer given the evidence from both in vitro and in vivo evaluations (Table 2). Cancer metastases can be inhibited by the modulation of the cytoskeleton and cell motility processors. Modulation of cell growth and differentiation as well as cell cycle arrest interfere with tumor proliferation and survival. Starving tumors by targeting angiogenesis as well as triggering apoptosis leads to inhibition of progression and survival. Interfering with different cell signaling pathways linking AKT and ERK modulates cell metabolism and disfavors progression and survival.

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<a href="https://www.researchgate.net/figure/The-cellular-and-molecular-targets-of-lignans-Flaxseed-lignans-have-the-ability-to_fig5_332997420"><img src="https://www.researchgate.net/publication/332997420/figure/fig5/AS:757077504962560@1557512751087/The-cellular-and-molecular-targets-of-lignans-Flaxseed-lignans-have-the-ability-to.png" alt="The cellular and molecular targets of lignans. Flaxseed lignans have the ability to target multiple pathways in cancer given the evidence from both in vitro and in vivo evaluations (Table 2). Cancer metastases can be inhibited by the modulation of the cytoskeleton and cell motility processors. Modulation of cell growth and differentiation as well as cell cycle arrest interfere with tumor proliferation and survival. Starving tumors by targeting angiogenesis as well as triggering apoptosis leads to inhibition of progression and survival. Interfering with different cell signaling pathways linking AKT and ERK modulates cell metabolism and disfavors progression and survival."/></a>