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The 2 longest Fibonacci Spike UA/CG Metastructures are either suppressed (2584 UA/CG) or reduced (1594 US/CG « PODIUMS » top value) in all 7 OMICRONS variants analyzed with the exception of MINESOTA OMICRON Strain which is a different sub-clade.
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We analyzed 15 genomes and Spikes of the new OMICRON variant, on the one hand 7 from the very first 21K lineage (South Africa, USA, Belgium, Canada), on the other hand 8 from the later second sister-clade 21L (USA , Switzerland, UK).
We applied, at the scale of the whole genome and the spike gene, the biomathematics method of Fibonacci meta-struct...
Citations
... It should be emphasized that a significant proportion of the COVID-19 PVS in mRNA vaccine recipients is due to toxic spike proteins, and the inclusion of structures in the receptor-binding domain within these proteins that may induce prion disease is particularly alarming, as Seneff et al. and Perez et al. have warned [50,[90][91][92][93][94][95][96]. Furthermore, it has been shown that prion similarity in the receptor-binding domain exists not only in the spike protein of the Wuhan strain, which is still used as an antigen in genetic vaccines, but also in the spike protein of variants of SARS-CoV-2, such as the Delta strain, with the exception of the Omicron strain [93,97]. Whether we should be uniformly vigilant for the spike protein of the coronavirus or just the spike protein of certain variants, such as the Wuhan strain, awaits further analysis. ...
The coronavirus pandemic was declared by the World Health Organization (WHO) in 2020, and a global genetic vaccination program has been rapidly implemented as a fundamental solution. However, many countries around the world have reported that so-called genetic vaccines, such as those using modified mRNA encoding the spike protein and lipid nanoparticles as the drug delivery system, have resulted in post-vaccination thrombosis and subsequent cardiovascular damage, as well as a wide variety of diseases involving all organs and systems, including the nervous system. In this article, based on these circumstances and the volume of evidence that has recently come to light, we call the attention of medical professionals to the various risks associated with blood transfusions using blood products derived from people who have suffered from long COVID and from genetic vaccine recipients, including those who have received mRNA vaccines, and we make proposals regarding specific tests, testing methods, and regulations to deal with these risks. We expect that this proposal will serve as a basis for discussion on how to address post-vaccination syndrome and its consequences following these genetic vaccination programs.
... Both the SSP and UNMR are supramolecular in origin, and discussed in a book by Hans Selye titled "In Vivo -the Case for for "prime time". Recent compelling epidemiological data [73][74][75][76] support the view that the bar is set too low for mRNA vaccines, in terms of safety, both short and long term. It might be asked, what level of off-target effects should be tolerated? ...
... The presence of the prion region in the SARS-CoV-2 spike embedded in the COVID-19 injectables was formally demonstrated by Tetz and Tetz (2022) as summed up in Figure 1. And, in Perez, Lounnas, and Montagnier (2021), we showed that all SARS-CoV-2 Wuhan strain variants, and all of the COVID-19 vaccines have this prion region, although it disappears totally in the Omicron variant (for the details of that disappearance, see the Appendix to this paper). ...
Creutzfeldt-Jakob Disease, the formerly rare but universally fatal prion disease in humans, normally progresses over several decades before it leads to death. In the Appendix to this paper, we highlight the presence of a prion region in the spike protein of the original SARS-CoV-2, and in all the “vaccine” variants built from the Wuhan virus. The prion region in the spike of SARS-CoV-2 has a density of mutations eight times greater than that of the rest of the spike, and, yet, strangely that entire prion region disappears completely in the Omicron variant. In the main body of our text, we present 26 cases of Creuzfeldt-Jacob Disease, all diagnosed in 2021 with the first symptoms appearing within an average of 11.38 days after a Pfizer, Moderna, or AstraZeneca COVID-19 injection. Because the causal progression, the etiopathogenesis, of these atypical and new cases of human prion disease — cases of what is apparently a totally new form of rapidly developing Creuzfeldt-Jacob Disease — we focus on the chronology of the symptomatic development. We consider it from an anamnestic point of view — one in which we compare the typical development of pre-COVID cases of Creuzfeldt-Jacob Disease to the extremely accelerated development of similar symptoms in the 26 cases under examination. By such an approach, we hope to work out the etiopathogenesis critical to understanding this new and much more rapidly developing human prion disease. By recalling the sequential pathway of that the formerly subacute and slowly developing disease followed in the past, and by comparing it with this new, extremely acute, rapidly developing prion disease — one following closely after one or more of the COVID-19 injections — we believe it is correct to infer that the injections caused the disease in these 26 cases. If so, they have probably also caused a many other cases that have gone undiagnosed because of their rapid progression to death. By late 2021, 20 had died within 4.76 months of the offending injection. Of those, 8 died suddenly within 2.5 months confirming the rapid progression of this accelerated form of Creuzfeldt-Jacob Disease. By June 2022, 5 more patients had died, and at the time of this current writing, only 1 remains still alive.
... The presence of the prion region in the SARS-CoV-2 spike embedded in the COVID-19 injectables was formally demonstrated by Tetz and Tetz (2022) as summed up in Figure 1. And, in Perez, Lounnas, and Montagnier (2021), we showed that all SARS-CoV-2 Wuhan strain variants, and all of the COVID-19 vaccines have this prion region, although it disappears totally in the Omicron variant (for the details of that disappearance, see the Appendix to this paper). ...
Creutzfeldt-Jakob Disease, the formerly rare but universally fatal prion disease in humans, normally progresses over several decades before it leads to death. In the Appendix to this paper, we highlight the presence of a prion region in the spike protein of the original SARS-CoV-2, and in all the “vaccine” variants built from the Wuhan virus. The prion region in the spike of SARS-CoV-2 has a density of mutations eight times greater than that of the rest of the spike, and, yet, strangely that entire prion region disappears completely in the Omicron variant. In the main body of our text, we present 26 cases of Creuzfeldt-Jacob Disease, all diagnosed in 2021 with the first symptoms appearing within an average of 11.38 days after a Pfizer, Moderna, or AstraZeneca COVID-19 injection. Because the causal progression, the etiopathogenesis, of these atypical and new cases of human prion disease — cases of what is apparently a totally new form of rapidly developing Creuzfeldt-Jacob Disease — we focus on the chronology of the symptomatic development. We consider it from an anamnestic point of view — one in which we compare the typical development of pre-COVID cases of Creuzfeldt-Jacob Disease to the extremely accelerated development of similar symptoms in the 26 cases under examination. By such an approach, we hope to work out the etiopathogenesis critical to understanding this new and much more rapidly developing human prion disease. By recalling the sequential pathway of that the formerly subacute and slowly developing disease followed in the past, and by comparing it with this new, extremely acute, rapidly developing prion disease — one following closely after one or more of the COVID-19 injections — we believe it is correct to infer that the injections caused the disease in these 26 cases. If so, they have probably also caused a many other cases that have gone undiagnosed because of their rapid progression to death. By late 2021, 20 had died within 4.76 months of the offending injection. Of those, 8 died suddenly within 2.5 months confirming the rapid progression of this accelerated form of Creuzfeldt-Jacob Disease. By June 2022, 5 more patients had died, and at the time of this current writing, only 1 remains still alive.
... Remarkably, the density of the transformation in the spike prion suppresses the function of this prion. On the one hand, the considerable variation in the spike region of the Omicron loss of the mRNA's hairpin conformation leads to the genome's fragility [24]. The Q493R mutation in the spike gene overlaps with many monoclonal binding sites [25]. ...
... Most of the studies revealed that the Omicron variants are less infectious than the other variants of SARS-CoV-2 but are more contagious [24]. The high transmissibility was shown in Figure 3 among the Kurdish population, which, since its appearance and nine months, the Omicron variants became the stand-alone variants despite the vaccination. ...
Citation: Majed, S.O.; Mustafa, S.A.; Jalal, P.J.; Fatah, M.H.; Miasko, M.; Jawhar, Z.; Karim, A.Y. SARS-CoV-2 Omicron Variant Genomic and Abstract: Omicron variants have been classified as Variants of Concern (VOC) by the World Health Organization (WHO) ever since they first emerged as a result of a significant mutation in this variant, which showed to have an impact on transmissibility and virulence of the virus, as evidenced by the ongoing modifications in the SARS-CoV-2 virus. As a global pandemic, the Omicron variant also spread among the Kurdish population. This study aimed to analyze different strains from different cities of the Kurdistan region of Iraq to show the risk of infection and the impact of the various mutations on immune responses and vaccination. A total of 175 nasopharyngeal/oropharyngeal specimens were collected at West Erbil Emergency Hospital and confirmed for SARS-CoV-2 infection by RT-PCR. The genomes of the samples were sequenced using the Illumina COVID-Seq Method. The genome analysis was established based on previously published data in the GISAID database and compared to previously detected mutations in the Omicron variants, and that they belong to the BA.1 lineage and include most variations determined in other studies related to transmissibility, high infectivity and immune escape. Most of the mutations were found in the RBD (receptor binding domain), the region related to the escape from humoral immunity. Remarkably, these point mutations (G339D, S371L, S373P, S375F, T547K, D614G, H655Y, N679K and N969K) were also determined in this study, which were unique, and their impact should be addressed more. Overall, the Omicron variants were more contagious than other variants. However, the mortality rate was low, and most infectious cases were asymptomatic. The next step should address the potential of Omicron variants to develop the next-generation COVID-19 vaccine.
... Both the SSP and UNMR are supramolecular in origin, and discussed in a book by Hans Selye titled "In Vivo -the Case for for "prime time". Recent compelling epidemiological data [73][74][75][76] support the view that the bar is set too low for mRNA vaccines, in terms of safety, both short and long term. It might be asked, what level of off-target effects should be tolerated? ...
Adverse events of myocarditis, pericarditis, and thrombosis, temporally associated with mRNA vaccination(s) and/or mRNA vaccine boosters, have been reported during post-marketing safety surveillance in the U.S. CDC VAERS database and 2021 CDC guidance to physicians. An interim report unexpectedly revealed inflammatory biomarker elevations in vaccine recipients. During review of considerable published research on the Sanarelli-Shwartzman phenomenon (SSP) and the use of nucleic acids as vaccine adjuvants, a novel, hypothesis is proposed. Even today, after being studied for over a century, the pathophysiology of the SSP is not fully understood. Motivated by a paper from 1950, titled "General Adaptation Syndrome" by Hans Selye, and recent published research by Korean investigators, a novel, non-conventional hypothesis was generated. Gluten and lectin sensitivity are cited as examples of sensitizing events of the SSP, for which we propose ensemble hydrophobic chiroptical catalysis may have therapeutic benefit. Under the ensemble HCC hypothesis, we propose that inflammatory stress and scurvy promote loss of chirality control, anomeric fidelity, phenotypic stability, and immune function, both humoral and cell-mediated, with the dialyzable transfer factor, L-ascorbic acid, and spin water playing central roles. It is proposed that therapeutic synergy of L-ascorbic acid, bioflavonoids, and corticosteroids in countering the SARS-CoV-2 pathogen arises from memory of chirality which originated during their biosynthesis. It is proposed that ensemble HCC is powered by radiant and or zero-point energy (quantum vacuum fluctuations) which may support a paradigm shift to supramolecular biology. The distinction between supramolecular biology and supramolecular xenobiology is highlighted.
... In addition, 1175 (0.2%) putative recombinant genomes were identified among 537,360 genomes, and it was reported that up to 5% of SARS-CoV-2 that circulated in the USA and UK might be recombinants [18]. Moreover, the number of cases that capture detection of recombinant genomes is growing [10,[13][14][15][16][17][18][19][20][21][22][23][24][25], including with recombinant events involving or between Omicron variants [36][37][38][39], which highlights the importance of recombination in the evolution of SARS-CoV-2. Besides recombination between SARS-CoV-2 infecting the same human cells, other evolutionary pathways may exist [39]. ...
... Moreover, the number of cases that capture detection of recombinant genomes is growing [10,[13][14][15][16][17][18][19][20][21][22][23][24][25], including with recombinant events involving or between Omicron variants [36][37][38][39], which highlights the importance of recombination in the evolution of SARS-CoV-2. Besides recombination between SARS-CoV-2 infecting the same human cells, other evolutionary pathways may exist [39]. For instance, different evolutionary trajectories in distinct cell types of the same infected host have been reported [40], and coronaviruses have been reported to harbor a sequence shared with four different families of positive-sense single-stranded RNA viruses and that is putatively shared with insects [41]. ...
Genetic recombination is a major evolutionary mechanism among RNA viruses, and it is common in coronaviruses, including those infecting humans. A few SARS-CoV-2 recombinants have been reported to date whose genome harbored combinations of mutations from different mutants or variants, but only a single patient’s sample was analyzed, and the virus was not isolated. Here, we report the gradual emergence of a hybrid genome of B.1.160 and Alpha variants in a lymphoma patient chronically infected for 14 months, and we isolated the recombinant virus. The hybrid genome was obtained by next-generation sequencing, and the recombination sites were confirmed by PCR. This consisted of a parental B.1.160 backbone interspersed with two fragments, including the spike gene, from an Alpha variant. An analysis of seven sequential samples from the patient decoded the recombination steps, including the initial infection with a B.1.160 variant, then a concurrent infection with this variant and an Alpha variant, the generation of hybrid genomes, and eventually the emergence of a predominant recombinant virus isolated at the end of the patient’s follow-up. This case exemplifies the recombination process of SARS-CoV-2 in real life, and it calls for intensifying the genomic surveillance in patients coinfected with different SARS-CoV-2 variants, and more generally with several RNA viruses, as this may lead to the appearance of new viruses.
... When we apply the Fibonacci meta-structure analysis we observe that these fractal meta-structures (except for the California case) remain high at the whole-genome level (data and results presented in extenso elsewhere [20]). ...
... illustrates the progressive loss of meta-structures in the S gene essential for infectiousness along the course of the pandemic. From D614G to Delta the short-range meta-structure at 377 UA/CG nucleotide length drops considerably during a first phase (2020-2021) and subsequently very recently, with the Omicron 21K sub-clade, the long-range meta-structures of 1797 and 2584 UA/CG lengths tend to disappear marking the disruption of the virus genome fractal cohesion, in relation with a loss of RNA secondary structure conformation (hairpin loops) in this particular gene[20]. ...
.The emergence of the Omicron variant of SARS-CoV2 identified first in South Africa was announced with anxiety in media following alarm and concern by many researchers in the scientific community and the WHO has declared it a variant of concern (VOC): “The discovery of a highly mutated coronavirus variant in South Africa has triggered a global scramble” [1]. The main reason for this turmoil is the exploding number of non-synonymous mutations in the gene coding the spike protein causing lungs and other organs cell entry. However, objectively, although this variant may be very contagious it has not yet demonstrated any particular killing capability as the WHO reports: “There is currently no information to suggest that symptoms associated with Omicron are different from those from other variants. Initially reported infections were among university students—younger individuals who tend to have a more mild disease—but understanding the level of severity of the Omicron variant will take days to several weeks” [2]. A report deposited on medRxiv indicates that the mRNA vaccine is 4 to 6 fold less neutralizing Omicron than for the wild-type virus [3]. Another report by the University of Hong Kong shows that it replicates considerably less in the lung tissue compared with bronchus which may diminish the lethality [4]. So the question we discuss here is the potential causes and effects of a heavy mutational rate on the virus contagiousness and infectiousness.
We compare the evolution of 14 genomes of monkeypox viruses including that of May 2022 that is currently spreading among humans in numerous countries outside Africa. Our aim was to discover mutations and other viral evolutions (recombination) of the virus genome that may explain the sudden impact of this epidemic circulating at very low-level and alert on its potential pathogenic character. We have evidenced the presence of a succession of a large number of T bases between the DNA-dependent RNA polymerase subunit rpo132 and the cowpox A-type inclusion protein, progressively rising from the absence of a characteristically long pattern of T-bases found in succession (≤ 10) in the early genomes of 1971, up to the 19 T-base sequence in the Israel 2018 reference strain and the 30 T bases thereafter in the 2022 strains. We find a complementary match for this long sequence of T bases only in the simian hemorrhagic encephalitis virus, at the 3’ end of the genome with a long succession of 28 A-bases after the stop codon. More strikingly, we find that the corresponding 10 phenyl-alanine aa chain is reported as matching uniquely (E≤0.001) a hypothetical protein element in Plasmodium falciparum, Yersinia pestis, Escherichia coli and Penicillium nordicum. We wonder whether this region of the monkeypox genome situated right upstream this long T-repeat may potentially code for a not yet identified polypeptide sequences with a functional role.
Adverse events of myocarditis, pericarditis, and thrombosis, temporally associated with mRNA vaccination(s) and/or mRNA vaccine boosters, have been reported during post-marketing safety surveillance in the U.S. CDC VAERS database and 2021 CDC guidance to physicians. An interim report unexpectedly revealed inflammatory biomarker elevations in vaccine recipients. During review of considerable published research on the Sanarelli-Shwartzman phenomenon (SSP) and the use of nucleic acids as vaccine adjuvants, a novel, hypothesis is proposed. Even today, after being studied for over a century, the pathophysiology of the SSP is not fully understood. Motivated by a paper from 1950, titled "General Adaptation Syndrome" by Hans Selye, and recent published research by Korean investigators, a novel, non-conventional hypothesis was generated. Gluten and lectin sensitivity are cited as examples of sensitizing events of the SSP, for which we propose ensemble hydrophobic chiroptical catalysis may have therapeutic benefit. Under the ensemble HCC hypothesis, we propose that inflammatory stress and scurvy promote loss of chirality control, anomeric fidelity, phenotypic stability, and immune function, both humoral and cell-mediated, with the dialyzable transfer factor, L-ascorbic acid, and spin water playing central roles. It is proposed that therapeutic synergy of L-ascorbic acid, bioflavonoids, and corticosteroids in countering the SARS-CoV-2 pathogen arises from memory of chirality which originated during their biosynthesis. It is proposed that ensemble HCC is powered by radiant and or zero-point energy (quantum vacuum fluctuations) which may support a paradigm shift to supramolecular biology. The distinction between supramolecular biology and supramolecular xenobiology is highlighted.
