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Copolymers of styrene and maleic acid of relatively low molecular weight possess a great potential for application as components of drug delivery systems, especially in cancer chemotherapy. The pioneering research in this area has been performed in the 1980s during the development of macromolecular complexes for selective drug delivery to solid tum...
Contexts in source publication
Context 1
... PSMA copolymers are usually synthesized by radical polymerization of a mixture of styrene and maleic anhydride, followed by hydrolysis ofthe anhydride bonds in the obtained copolymer (Fig. 1). The process is classically performed in boiling (152-153 ºC) cumene by using dicumyl peroxide as a radical initiator [17,18]. The obtained copolymer anhydride is thus cumene- terminated. Copolymers of various molecular mass ...
Context 2
... PSMA copolymers are usually synthesized by radical polymerization of a mixture of styrene and maleic anhydride, followed by hydrolysis ofthe anhydride bonds in the obtained copolymer (Fig. 1). The process is classically performed in boiling (152-153 ºC) cumene by using dicumyl peroxide as a radical initiator [17,18]. The obtained copolymer anhydride is thus cumene- terminated. Copolymers of various molecular mass ...
Citations
... Multivariate statistical analyses (MVAs) have been widely applied to cancer genomics and proteomics in humans but rarely in the context of experimental cancer studies in animal models. In this study, we sought to investigate their value in the context of understanding the tumor suppressive actions of a 2 nd -generation curcumin (diferuloylmethane) analogue, 3,5-bis(3,4,5-trimethoxybenzylidene)-1-methylpiperidine-4-one (RL71) [1][2][3][4][5][6][7][8][9], encapsulated in styrene maleic acid (SMA) micelles (SMA-RL71; [10][11][12][13]), in animals expressing a xenograft model of triple negative breast cancer (TNBC). In this model of TNBC, SMA-RL71 (10 mg/kg, iv.) was previously shown to decrease tumor growth by 67% and modulated the expression of EGFR, Akt, mTOR, and 4EBP1 [13]. ...
We have previously shown that the curcumin derivative 3,5-bis(3,4,5-trimethoxybenzylidene)-1-methylpiperidine-4-one (RL71), when encapsulated in styrene maleic acid micelles (SMA-RL71), significantly suppressed the growth of MDA-MB-231 xenografts by 67%. Univariate statistical analysis showed that pEGFR/EGFR, pAkt/Akt, pmTOR/mTOR and p4EBP1/4EPBP1 were all significantly decreased in tumors from treated mice compared to SMA controls. In this study, multivariate statistical analyses (MVAs) were performed to identify the molecular networks that worked together to drive tumor suppression, with the aim to determine if this analysis could also be used to predict treatment outcome. Linear discriminant analysis correctly predicted, to 100% certainty, mice that received SMA-RL71 treatment. Additionally, results from multiple linear regression showed that the expression of Ki67, PKC-α, PP2AA-α, PP2AA-β and CaD1 networked together to drive tumor growth suppression. Overall, the MVAs provided evidence for a molecular network of signaling proteins that drives tumor suppression in response to SMA-RL71 treatment, which should be explored further in animal studies of cancer.
