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Fig 4 - A tEMTing target? Clinical and experimental evidence for epithelial-mesenchymal transition in the progression of cutaneous squamous cell carcinoma (a scoping systematic review)

Fig. 4 Synthesis of EMT signalling in cSCC based on clinical and experimental studies evaluated in this review (Supplementary Table 1 and 2). The signalling investigated by cell line-based studies was merged in this EMT pathway map under the assumption of transferability between the different aetiologies and models. Multiple changes can induce EMT in cSCC. Hormonal, cytokine, growth factor, ECM signalling all contribute cooperatively to the extent and nature of the EMT programme. Central signalling hubs such as Akt, MKKs or NFκB are attractive drug targets that could be used to attenuate EMT in cSCC [76]
Synthesis of EMT signalling in cSCC based on clinical and experimental studies evaluated in this review (Supplementary Table 1 and 2). The signalling investigated by cell line-based studies was merged in this EMT pathway map under the assumption of transferability between the different aetiologies and models. Multiple changes can induce EMT in cSCC. Hormonal, cytokine, growth factor, ECM signalling all contribute cooperatively to the extent and nature of the EMT programme. Central signalling hubs such as Akt, MKKs or NFκB are attractive drug targets that could be used to attenuate EMT in cSCC [76]
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