Fig 1 - uploaded by Gamal Abdelaziz
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Structure of human pro-insulin. 82-polypeptide hormone consisting of the A chain (21 a.a.) and the B chain (30 a.a.) linked by two disulfide bridges (Cys7A–Cys7B / Cys20A–Cys19B). One more intrachain disulfide bond is located between Cys6–Cys11 within the A chain (Murray et al, 2003).
Source publication
Objective, still production of human recombinant insulin is big target for developing countries although
it produced recombinant since 1982. Material and Methods: Human pro-insulin gene codons optimization with aid
of a web based software called OPTIMIZER, where codons that rarely used by E.coli were replaced by abundant
codons, without any changin...
