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Structure-activity relationship of safe-in-man BSAAs. Web-application serves C-SPADE was used to cluster BSAAs based on their structural similarities and visualize them as a dendrogram of compounds augmented with their functional annotations (https://cspade.fimm.fi/).

Structure-activity relationship of safe-in-man BSAAs. Web-application serves C-SPADE was used to cluster BSAAs based on their structural similarities and visualize them as a dendrogram of compounds augmented with their functional annotations (https://cspade.fimm.fi/).

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Viral diseases are one of the leading causes of morbidity and mortality in the world. Virus-specific vaccines and antiviral drugs are the most powerful tools to combat viral diseases. However, broad-spectrum antiviral agents (BSAAs, i.e. compounds targeting viruses belonging to two or more viral families) could provide additional protection of gene...

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... BSAAs inhibit viral or host factors and block viral replication, reduce the viral burden to a level at which host immune responses can deal with it or facilitate apoptosis of infected cells (Table S1). Analysis of BSAA targets and structures (Figure 4) revealed that the most abundant are nucleotide and nucleoside analogues which inhibit viral RNA and DNA polymerases. Imatinib, erlotinib, gefitinib, and dasatinib, which inhibit tyrosine kinases, are the most abundant hostdirected BSAAs. ...
Context 2
... BSAAs possess not only antiviral but also antibacterial activity (Figure 4; Table S1) (Schor and Einav, 2018). Moreover, 13 of the 50 agents are approved as antibiotics (2 withdrawn). ...
Context 3
... addition, BSAAs showed activity against a wide range of other medically important human pathogens, including fungi, protozoa and parasites (Table S1) (Montoya and Krysan, 2018), pointing out that some pathogens utilize common mechanisms to infect hosts. Moreover, structure-activity relationship analysis of BSAAs suggests that some agents, such as doxycycline, artesunate, omeprazole, nitazoxanide, suramin, azithromycin, minocycline and chloroquine, could have novel antibacterial, antiprotozoal, antifungal or anthelmintic activities (Figure 4). If confirmed, this could lead to development of broad-spectrum anti-infective drugs. ...

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Full-text available
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