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Significant dysregulation of P53 pathway in urothelial cells exposed to either S. haematobium or S. mansoni eggs for 24 hours. P53 pathway highlighting upregulated or downregulated genes in red or green, respectively. Genes affected by S. mansoni or S. haematobium are indicated by blue or red squares, respectively (Nacif-Pimenta et al., 2019).
Source publication
Schistosomiasis, or Bilharziasis, is a neglected tropical disease caused by Schistosoma parasites, which significantly impacts public health, particularly in Africa. Schistosoma haematobium, the primary species responsible for urogenital schistosomiasis (UGS), is associated with severe chronic conditions, including squamous cell carcinoma (SCC) of...
Context in source publication
Context 1
... repair and apoptosis, new mutations may arise, creating a conducive environment for malignant transformation. Santos et al. (2021) demonstrated a decrease in the p53 pathway in urothelial cells exposed to live S. haematobium or S. mansoni eggs (Figure 4). However, the specific genes responsible for the pathway's overall downregulation differed for each Schistosoma species ( Lu et al., 2022). ...
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