Figure 3 - available via license: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
Content may be subject to copyright.
Source publication
Introduction and Importance
The use of cyclophosphamide in women of childbearing age with severe systemic lupus erythematosus is normally indicated. However, cyclophosphamide is generally avoided during pregnancy due to the risk of teratogenicity, especially since its effect on fetal survival is poorly understood. This is a case report of a lupus p...
Context in source publication
Context 1
... and they were normal. At close monitoring of the fetus every 35 weeks of gestation, she gave birth, and a healthy-looking boy was born, without any obvious congenital malformations, and by following up the child is alive and does not complain of any deformities or secondary neoplasms such as lymphoma, leukemia, and myeloproliferative disorders (Fig. ...
Citations
... Well-known side toxic effects of conventional doses of cyclophosphamide are nausea, alopecia, infertility, pulmonary fibrosis, bladder injury, etc [9,10]. Furthermore, CP has carcinogenic and teratogenic potential [4,11]. ...
Background and purpose: Cyclophosphamide (CP) is a widely used antitumor and immunosuppressive drug, but it is highly cytotoxic and has carcinogenic and teratogenic potential. To reduce adverse effects of CP therapy and the frequency of its administration, the microencapsulation of CP into biodegradable polymeric matrices can be performed. However, according to the literature, only a few polymers were found suitable to encapsulate CP and achieve its’ sustained release. Experimental approach: In this research, spray-dried cyclophosphamide-loaded poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microparticles were prepared and characterized in terms of their average hydrodynamic diameter, polydispersity index, surface morphology, zeta potential, encapsulation efficiency, drug loading, thermal properties and cytotoxicity against 3T3 cells. Key results: The obtained CP-loaded microparticles had a regular spherical shape, uniform size distribution with an average diameter of 4.21±0.04 μm and zeta potential of -34.2±0.2 mV. The encapsulation of cyclophosphamide into the PHBV matrix led to a decrease in melting and degradation temperatures and an increase in diameter, glass transition and cold crystallization temperatures compared to blank microparticles. Moreover, microencapsulation of cyclophosphamide lowered its cytotoxicity compared to the pure drug: the number of dead cells in the culture decreased by 28 %, while their metabolic activity increased by 20 %. The cumulative in vitro drug release studies showed a gradual release of CP up to 18 days, so the obtained microparticle formulation can be used as a sustained-release cyclophosphamide delivery system. Conclusion: In this research, a novel cyclophosphamide-loaded platform based on PHBV microparticles was established and characterized. Overall, this study offers promising prospects for cancer therapy in the future.
Objective: Stroke among young and elderly people is frequently caused by cervical artery dissection (CeAD). A rupture in any one or more blood vessel layers of tissue results in cervical artery detachment. Information for the causative factor of one-fifth of ischemic stroke patients is available from case reports and case reviews. CeAD is rare during pregnancy and in the early postpartum period. In addition, other risk factors have been suggested, such as infection, migraine, hyperhomocysteinaemia, and the 677TT genotype of the 5,10-methylenetetrahydrofolate reductase gene (MTHFR 677TT). Limitation: A lack of neurological diseases during pregnancy and the postpartum period provides major obstacles for both the mother and child. The restricted therapeutic choices might impair care and complicate management. Multidisciplinary care is frequently required to achieve a delicate equilibrium between the health of the mother and the risk of foetal hazards. Method: This systematic review with a systematically registered protocol was the strategy to study the clinical presentation, management, and outcome of this situation. For inclusion, 40 studies were found through language-free searches on Google Scholar and PubМed. Results: The key factors of the greatest incidence found were migraine, hyperlipidemia, connective tissue diseases, HELLP syndrome, preeclampsia or eclampsia, and the protracted second phase of labor. The most frequent complaint was a headache with soreness in the neck. Anticoagulant medication, anti-platelet agents, and endovascular procedures were among the acute medical interventions. Conclusion: This research emphasizes the value of efficient, all-encompassing care and raised knowledge to optimize results in pregnant women.
