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Shave biopsy of skin displaying a Merkel cell carcinoma with pure neuroendocrine morphology at scanning, (a) and high, (b) magnification. The neoplastic small blue round cells exhibit spotty nuclear positivity for Merkel cell polyomavirus, (c) and cytoplasmic positivity for CK20 (paranuclear dot and circumferential patterns), (d) synaptophysin (diffuse cytoplasmic pattern), (e) and neurofilament (scant dot‐like pattern), (f). Source: Walsh NM, Cerroni L. Merkel cell carcinoma: A review. J Cutan Pathol. 2021, Mar; 48(3):411–421. Reprinted with permission under license number 5601670806482.
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The nose is a structure of both cosmetic and functional importance. Cutaneous lesions of the nose occasionally represent a diagnostic challenge and involve the expertise of several specialties from dermatology, otolaryngology—head and neck surgery, infectious disease, and pathology, among others. We present a review of salient features of malignant...
