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Figure 1 - White Matter Disease as a Biomarker for Long-Term Cerebrovascular Disease and Dementia

Figure 1. Severity of MRI-detected white matter hyperintensity. Total burden of white matter disease varies significantly among asymptomatic adults and patients with known cerebrovascular disease. In age-matched individuals, white matter hyperintensity (WMH) volume may vary from mild to very severe ( upper panel ). Using validated semi-automated volumetric protocol, WMH volume can be quantified ( lower panel , in red , WMH maps are derived from contiguous supratentorial axial T2-FLAIR MRI slices using previously published method [10]) with a high degree of accuracy and precision. 
Severity of MRI-detected white matter hyperintensity. Total burden of white matter disease varies significantly among asymptomatic adults and patients with known cerebrovascular disease. In age-matched individuals, white matter hyperintensity (WMH) volume may vary from mild to very severe ( upper panel ). Using validated semi-automated volumetric protocol, WMH volume can be quantified ( lower panel , in red , WMH maps are derived from contiguous supratentorial axial T2-FLAIR MRI slices using previously published method [10]) with a high degree of accuracy and precision. 
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