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Serum sLOX-1 (a) and NO (b) levels of patients with acute ischemic stroke that compare simvastatin 10 mg/day and 40 mg/day at Day 90 after simvastatin treatment. P∗<0.05.
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Backgrounds
Stroke is the leading cause of death and long-term disability. Oxidative stress is elevated during occurrence of acute ischemic stroke (AIS). Soluble LOX-1 (sLOX-1) and NO are used as biomarkers for vascular oxidative stress that can reflect stabilization of atherosclerotic plaque. Previous study showed that simvastatin can reduce oxida...
Citations
... Statins as the mainstay in the management of dyslipidemia, are widely prescribed in Indonesia, based on their potential to prevent adverse cardiovascular events. Hypolipidemic effect of statins happened by inhibiting hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (Uransilp et al., 2018) and decreases LDL-C (Low-Density Lipoprotein Cholesterol) concentration due to the upregulation of LDL receptor activity (Nickenig, 2004). Early studies using statins to lower LDL cholesterol have shown reduced CHD (Coronary Heart Disease) rates and total mortality as well as reduced myocardial infarction, stroke, and peripheral vascular disease. ...
Dyslipidemia is the commonest cause of many atherosclerotic diseases. Statins are the mainstay of the management of dyslipidemia, and it is widely prescribed for patients in Indonesia. This study aims to give an overview, the use of statin, and its drug-drug interactions. The study method was descriptive, using a purposive sampling technic. The inclusion criteria were patients who received statins therapy, in the outpatient installation of Tugurejo Regional Public Hospital, Semarang, during April 2017. There were 334 patients meet the inclusion criteria, most of them were women (63,28%). The highest patients’ range was 60-69 years old of 129 patients (38,62%). One hundred and thirty-one patients (39,22%) were diagnosed with dyslipidemia only. The dosage range of simvastatin and rosuvastatin was 10 to 20 mg once daily, but rosuvastatin was only given 10 mg once daily. The most dose was 10 mg simvastatin per day, prescribed for 231 patients (69,16%). There were 177 patients (52,99%) who has the potentiate of statin drug interactions. The most were simvastatin-amlodipine interactions, occurs in 104 patients (31,14%). This study shows that most statin users are elderly patients. Statin is used not only in dyslipidemia patients. There are many potential statin drug-drug interactions, but the statin dose is low and not over the standard doses. Keyword: dyslipidemia, statins, drug interactions
Excessive consumption of a high-fat diet (HFD) is associated with hypercholesterolemia and cardiovascular disease (CVD). Dark purple maoberry (Antidesma bunius) fruit is a very good source of antioxidants. We investigated the effects of maoberry on immune function, lipid profiles, and oxidative stress in HFD-induced hypercholesterolemia. Seventy-two male Sprague Dawley rats were divided into the normal group fed with standard diet (ND); HFD groups (HF); and low, medium, and high dose of maoberry extract groups and a simvastatin group (HF-L, HF-M, HF-H, and HF-S, respectively). Maoberry groups were given maoberry extract at concentrations of 0.38, 0.76, and 1.52 g/kg per day. At the same time, HF-S groups were administered simvastatin 10 mg/kg per day. After 12 weeks of maoberry treatment, significant reductions in body weight and triglyceride levels were observed in HF-L, HF-M, and HF-H groups in comparison with HF groups (P < .05). Obvious negative changes in spleen histology were found in HF groups, but not in maoberry-treated groups. Modest, but not significant, improvements were observed in other lipid profiles, immune cells in peripheral blood, oxidative stress, and antioxidant capacity after maoberry supplementation. In summary, these findings suggest that maoberry was helpful in reducing atherogenic risk factors such as lipid profiles, especially triglyceride, inflammation, oxidative stress related to CVD, and lesions in spleen histopathology.
