Serotonin and glutamate receptor distribution related to brain atrophy in individuals with an FHAD and Alzheimer's disease. (A) The spatial distribution of the serotonin 5-HT6 receptor (n = 30) in cortical regions (n = 448) was negatively correlated with atrophy progression in both FHAD (n Baseline = 153) and Alzheimer's disease (n Baseline = 156) but was only significant in Alzheimer's disease after comparison with a spatial null distribution and FDR correction. (B) Positive and significant correlations were observed between the serotonin 5-HT6 receptor distribution (n = 30) and baseline atrophy (n FHAD = 153, n Alzheimer's disease = 156) in both groups, suggesting that the negative correlations most likely reflect a ceiling effect. In addition, the distribution of the serotonin 5-HT1B receptor (n = 88) was significantly correlated with baseline atrophy, but only in FHAD. Finally, significant correlations were observed between the metabotropic glutamate receptor 5 (mGluR5) distribution (n = 123) and baseline atrophy (n FHAD = 153, n Alzheimer's disease = 156) in both groups. All correlations were spatial Pearson's correlations performed across 448 cortical regions. The dots represent the spatial correlation coefficients for each group, while the asterisks (*) indicate statistically significant values after comparison with a spatial null distribution and FDR correction (1000 spins, P-value spin-FDR < 0.05).

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... regional factors may also influence the atrophy progression pattern, we examined the spatial correlations between this pattern and the distributions of seven neurotransmitter receptors and transporters (Fig. 6). A negative correlation between the distribution of the 5-HT6 receptors and atrophy progression in FHAD was observed (r = −0.15, P-value spin = 0.04), but did not remain significant after FDR correction (r = −0.15, P-value spin-FDR = 0.19). A negative correlation was also found between the distribution of these receptors and the ...