Selection of the sources of evidence

Selection of the sources of evidence

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Cutaneous squamous cell carcinoma (cSCC) is a disease with globally rising incidence and poor prognosis for patients with advanced or metastatic disease. Epithelial-mesenchymal transition (EMT) is a driver of metastasis in many carcinomas, and cSCC is no exception. We aimed to provide a systematic overview of the clinical and experimental evidence...

Context in source publication

Context 1
... screening of 3443 search results yielded 86 eligible studies (Fig. 1). Those excluded covered either a different disease (melanoma, BCC, cervical SCC, HNSCC), were secondary literature (review articles, book chapters), were unrelated to EMT, and/or used inducible murine models (DMBA, TPA, UV). Eligible studies encompassed 44 cell line-based (experimental) studies, 22 clinical studies, and 20 studies ...