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Selection of ProMED-mail reports to analyze for undiagnosed disease events related to human health, January 1, 2007-December 30, 2017.

Selection of ProMED-mail reports to analyze for undiagnosed disease events related to human health, January 1, 2007-December 30, 2017.

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We conducted a retrospective analysis of all reports in ProMED-mail that were initially classified as undiagnosed diseases during 2007-2018. We identified 371 cases reported in ProMED-mail; 34% were later diagnosed. ProMED-mail could be used to supplement other undiagnosed disease surveillance systems worldwide.

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Context 1
... conducted a retrospective analysis of all reports of undiagnosed diseases in the ProMED-mail registry that were published during January 1, 2007-June 14, 2018 ( Figure 1). ProMED-mail staff provided all the archives for undiagnosed diseases and unknown diseases relative to humans, animals, and plants. ...
Context 2
... described quantitative variables using median and range and qualitative variables using percentages. During January 1, 2007-June 14, 2018, a total of 775 ProMED-mail reports accounted for 371 individual undiagnosed disease events in humans (Fig- ure 1). The median number of undiagnosed disease events per year was 34 (range 15-45) ( Figure 2). ...

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... A review of ProMed reports of undiagnosed disease events shows that those events mainly occurred within low-resource countries. 2 New, emerging infectious diseases also present first as outbreaks of unknown aetiology, as in the first cases of acquired immunodeficiency syndrome, severe acute respiratory syndrome (SARS), Middle East respiratory syndrome and coronavirus disease 2019. 3 From our experience and literature review, little information is available to the scientific community about outbreaks where the cause is not identified or where there is controversy around the primary agent involved. ...
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