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Scheme 1. Synthesis of compounds 4a-f, 5a-f, and 6a.

Scheme 1. Synthesis of compounds 4a-f, 5a-f, and 6a.

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Among the compounds synthesized, derivative (VI) is found to be a potent inhibitor in vitro for the replication of HIV-1.

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A practical and strightforward approach that enables for the first time, the synthesis of enantiomerically pure 1,4,5- trisubstituted, 1,5-disubstituted, and fused 1,2,3 triazoles derivatives has been developed. The synthesis employs enantiomerically pure amino esters derived from amino acids and commercially available ketones under metla-free cond...